The Elder Dragon War

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — The Elder Dragon War deals 2 damage to each creature and each opponent.
II — Discard any number of cards, then draw that many cards.
III — Create a 4/4 red Dragon creature token with flying.

Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Grafted Butcher

When Grafted Butcher enters, Phyrexians you control gain menace until end of turn.
Other Phyrexians you control get +1/+1.
{3}{B}, Sacrifice an artifact or creature: Return Grafted Butcher from your graveyard to the battlefield. Activate only as a sorcery.

Phyrexian Awakening

When Phyrexian Awakening enters, incubate 4. (Create an Incubator token with four +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)
Phyrexians you control have vigilance.

Refraction Elemental

Ward—Pay 2 life.
Whenever you cast a spell, Refraction Elemental deals 2 damage to each opponent.

Invasion of Karsus

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Karsus enters, it deals 3 damage to each creature and each planeswalker.

Invasion of Karsus // Refraction Elemental

Brotherhood's End

Choose one —
• Brotherhood's End deals 3 damage to each creature and each planeswalker.
• Destroy all artifacts with mana value 3 or less.

Gift of Compleation

When Gift of Compleation enters, incubate 3. (Create an Incubator token with three +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)
Whenever a Phyrexian you control dies, surveil 1. (Look at the top card of your library. You may put that card into your graveyard.)

Norn's Inquisitor

When Norn's Inquisitor enters, incubate 2. (Create an Incubator token with two +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)
Whenever a permanent you control transforms into a Phyrexian, put a +1/+1 counter on it.

Bloated Processor

Sacrifice another Phyrexian: Put a +1/+1 counter on Bloated Processor.
When Bloated Processor dies, incubate X, where X is its power. (Create an Incubator token with X +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)

Marchesa, Resolute Monarch

Menace, deathtouch
Whenever Marchesa, Resolute Monarch attacks, remove all counters from up to one target permanent.
At the beginning of your upkeep, if you haven't been dealt combat damage since your last turn, you draw a card and you lose 1 life.

Invasion of Fiora

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Fiora enters, choose one or both —
• Destroy all legendary creatures.
• Destroy all nonlegendary creatures.

Invasion of Fiora // Marchesa, Resolute Monarch

Path of Peril

Cleave {4}{W}{B} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Destroy all creatures [with mana value 2 or less].

Sunfall

Exile all creatures. Incubate X, where X is the number of creatures exiled this way. (Create an Incubator token with X +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)

The Argent Etchings

(As this Saga enters and after your draw step, add a lore counter.)
I — Incubate 2 five times, then transform all Incubator tokens you control.
II — Creatures you control get +1/+1 and gain double strike until end of turn.
III — Destroy all other permanents except for artifacts, lands, and Phyrexians. Exile The Argent Etchings, then return it to the battlefield (front face up).

Elesh Norn

Vigilance
Whenever a source an opponent controls deals damage to you or a permanent you control, that source's controller loses 2 life unless they pay {1}.
{2}{W}, Sacrifice three other creatures: Exile Elesh Norn, then return it to the battlefield transformed under its owner's control. Activate only as a sorcery.

Elesh Norn // The Argent Etchings

Into the Fire

Choose one —
• Into the Fire deals 2 damage to each creature, planeswalker, and battle.
• Put any number of cards from your hand on the bottom of your library, then draw that many cards plus one.

Malicious Malfunction

All creatures get -2/-2 until end of turn. If a creature would die this turn, exile it instead.