Shrieking Affliction

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 3 life.

Infernal Grasp

Destroy target creature. You lose 2 life.

Sceptre of Eternal Glory

{T}: Add one mana of any color.
{T}: Add three mana of any one color. Activate only if you control three or more lands with the same name.

Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Gilded Lotus

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Tinybones, Trinket Thief

At the beginning of each end step, if an opponent discarded a card this turn, you draw a card and you lose 1 life.
{4}{B}{B}: Each opponent with no cards in hand loses 10 life.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Oppression

Whenever a player casts a spell, that player discards a card.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters, if it was kicked, target opponent discards two cards at random.

Geier Reach Sanitarium

{T}: Add {C}.
{2}, {T}: Each player draws a card, then discards a card.

Dreamstealer

Menace
Whenever Dreamstealer deals combat damage to a player, that player discards that many cards.
Eternalize {4}{B}{B} ({4}{B}{B}, Exile this card from your graveyard: Create a token that's a copy of it, except it's a 4/4 black Zombie Human Wizard with no mana cost. Eternalize only as a sorcery.)

Liliana, Waker of the Dead

+1: Each player discards a card. Each opponent who can't loses 3 life.
−3: Target creature gets -X/-X until end of turn, where X is the number of cards in your graveyard.
−7: You get an emblem with "At the beginning of combat on your turn, put target creature card from a graveyard onto the battlefield under your control. It gains haste."

Rise of the Dark Realms

Put all creature cards from all graveyards onto the battlefield under your control.

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Tasigur's Cruelty

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)
Each opponent discards two cards.

Plaguecrafter

When Plaguecrafter enters, each player sacrifices a creature or planeswalker of their choice. Each player who can't discards a card.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Hymn to Tourach

Target player discards two cards at random.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Stronghold Rats

Shadow (This creature can block or be blocked by only creatures with shadow.)
Whenever Stronghold Rats deals combat damage to a player, each player discards a card.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Liliana Vess

+1: Target player discards a card.
−2: Search your library for a card, then shuffle and put that card on top.
−8: Put all creature cards from all graveyards onto the battlefield under your control.

Blood Scrivener

If you would draw a card while you have no cards in hand, instead you draw two cards and you lose 1 life.

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Damnation

Destroy all creatures. They can't be regenerated.

Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Junji, the Midnight Sky

Flying, menace
When Junji, the Midnight Sky dies, choose one —
• Each opponent discards two cards and loses 2 life.
• Put target non-Dragon creature card from a graveyard onto the battlefield under your control. You lose 2 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Sol Ring

Larceny

Whenever a creature you control deals combat damage to a player, that player discards a card.

Bag of Holding

Whenever you discard a card, exile that card from your graveyard.
{2}, {T}: Draw a card, then discard a card.
{4}, {T}, Sacrifice Bag of Holding: Return all cards exiled with Bag of Holding to their owner's hand.

Archon of Cruelty

Flying
Whenever Archon of Cruelty enters or attacks, target opponent sacrifices a creature or planeswalker of their choice, discards a card, and loses 3 life. You draw a card and gain 3 life.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Dark Ritual

Mindslicer

When Mindslicer dies, each player discards their hand.

Ensnaring Bridge

Creatures with power greater than the number of cards in your hand can't attack.

Hypnotic Specter

Flying
Whenever Hypnotic Specter deals damage to an opponent, that player discards a card at random.

The Haunt of Hightower

Flying, lifelink
Whenever The Haunt of Hightower attacks, defending player discards a card.
Whenever a card is put into an opponent's graveyard from anywhere, put a +1/+1 counter on The Haunt of Hightower.

Virus Beetle

When Virus Beetle enters, each opponent discards a card.

Baleful Mastery

You may pay {1}{B} rather than pay this spell's mana cost.
If the {1}{B} cost was paid, an opponent draws a card.
Exile target creature or planeswalker.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Demogorgon's Clutches

Target opponent discards two cards, mills two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Swamp

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Gibbering Descent

At the beginning of each player's upkeep, that player loses 1 life and discards a card.
Hellbent — Skip your upkeep step if you have no cards in hand.
Madness {2}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice.

Charcoal Diamond

Charcoal Diamond enters tapped.
{T}: Add {B}.

Words of Waste

{1}: The next time you would draw a card this turn, each opponent discards a card instead.

Noetic Scales

At the beginning of each player's upkeep, return to its owner's hand each creature that player controls with power greater than the number of cards in their hand.

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Pilfer

Target opponent reveals their hand. You choose a nonland card from it. That player discards that card.

Wheel of Torture

At the beginning of each opponent's upkeep, Wheel of Torture deals X damage to that player, where X is 3 minus the number of cards in their hand.

Elderfang Disciple

When Elderfang Disciple enters, each opponent discards a card.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Containment Construct

Whenever you discard a card, you may exile that card from your graveyard. If you do, you may play that card this turn.

Liliana's Triumph

Each opponent sacrifices a creature of their choice. If you control a Liliana planeswalker, each opponent also discards a card.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Go for the Throat

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Raven's Crime

Target player discards a card.
Retrace (You may cast this card from your graveyard by discarding a land card in addition to paying its other costs.)

Liliana's Specter

Flying
When Liliana's Specter enters, each opponent discards a card.

Fell Specter

Flying
When Fell Specter enters, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.