Sygg, River Cutthroat

At the beginning of each end step, if an opponent lost 3 or more life this turn, you may draw a card. (Damage causes loss of life.)

Serra the Benevolent

+2: Creatures you control with flying get +1/+1 until end of turn.
−3: Create a 4/4 white Angel creature token with flying and vigilance.
−6: You get an emblem with "If you control a creature, damage that would reduce your life total to less than 1 reduces it to 1 instead."

Sythis, Harvest's Hand

Whenever you cast an enchantment spell, you gain 1 life and draw a card.

Sanctum of Shattered Heights

{1}, Discard a land card or Shrine card: Sanctum of Shattered Heights deals X damage to target creature or planeswalker, where X is the number of Shrines you control.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Sanctum Custodian

{T}: Prevent the next 2 damage that would be dealt to any target this turn.

Serum Visions

Sanctum of Stone Fangs

At the beginning of your first main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Sol Ring

Sanctum Gargoyle

Flying
When this creature enters, you may return target artifact card from your graveyard to your hand.

Sanctum of Calm Waters

At the beginning of your first main phase, you may draw X cards, where X is the number of Shrines you control. If you do, discard a card.

Shalai, Voice of Plenty

Flying
You, planeswalkers you control, and other creatures you control have hexproof.
{4}{G}{G}: Put a +1/+1 counter on each creature you control.

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Shanid, Sleepers' Scourge

Menace
Other legendary creatures you control have menace.
Whenever you play a legendary land or cast a legendary spell, you draw a card and you lose 1 life.

Sanctum Weaver

{T}: Add X mana of any one color, where X is the number of enchantments you control.

Sanctum of Tranquil Light

{5}{W}: Tap target creature. This ability costs {1} less to activate for each Shrine you control.

Saskia the Unyielding

Vigilance, haste
As Saskia enters, choose a player.
Whenever a creature you control deals combat damage to a player, it deals that much damage to the chosen player.

Skrelv's Hive

At the beginning of your upkeep, you lose 1 life and create a 1/1 colorless Phyrexian Mite artifact creature token with toxic 1 and "This token can't block."
Corrupted — As long as an opponent has three or more poison counters, creatures you control with toxic have lifelink.

Saffi Eriksdotter

Sacrifice Saffi Eriksdotter: When target creature is put into your graveyard this turn, return that card to the battlefield.

Surrak Dragonclaw

Flash
This spell can't be countered.
Creature spells you control can't be countered.
Other creatures you control have trample.

Sterling Grove

Other enchantments you control have shroud. (They can't be the targets of spells or abilities.)
{1}, Sacrifice this enchantment: Search your library for an enchantment card, reveal it, then shuffle and put that card on top.

Samut, Voice of Dissent

Flash
Double strike, vigilance, haste
Other creatures you control have haste.
{W}, {T}: Untap another target creature.

Sultai Charm

Choose one —
• Destroy target monocolored creature.
• Destroy target artifact or enchantment.
• Draw two cards, then discard a card.

Sisay, Weatherlight Captain

Sisay gets +1/+1 for each color among other legendary permanents you control.
{W}{U}{B}{R}{G}: Search your library for a legendary permanent card with mana value less than Sisay's power, put that card onto the battlefield, then shuffle.

Saryth, the Viper's Fang

Other tapped creatures you control have deathtouch.
Other untapped creatures you control have hexproof.
{1}, {T}: Untap another target creature or land you control.

Sanctum of All

At the beginning of your upkeep, you may search your library and/or graveyard for a Shrine card and put it onto the battlefield. If you search your library this way, shuffle.
If an ability of another Shrine you control triggers while you control six or more Shrines, that ability triggers an additional time.

Sanctum of Fruitful Harvest

At the beginning of your first main phase, add X mana of any one color, where X is the number of Shrines you control.

Skrelv, Defector Mite

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Skrelv can't block.
{W/P}, {T}: Choose a color. Another target creature you control gains toxic 1 and hexproof from that color until end of turn. It can't be blocked by creatures of that color this turn. ({W/P} can be paid with either {W} or 2 life.)