Unwilling Ingredient

Menace (This creature can't be blocked except by two or more creatures.)
{2}{B}, Exile Unwilling Ingredient from your graveyard: You draw a card and you lose 1 life.

Phyrexian Rager

When Phyrexian Rager enters, you draw a card and you lose 1 life.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Sign in Blood

Target player draws two cards and loses 2 life.

Death's Shadow

Death's Shadow gets -X/-X, where X is your life total.

Infernal Grasp

Destroy target creature. You lose 2 life.

Shadow of Mortality

If your life total is less than your starting life total, this spell costs {X} less to cast, where X is the difference.

Evolved Sleeper

{B}: Evolved Sleeper becomes a Human Cleric with base power and toughness 2/2.
{1}{B}: If Evolved Sleeper is a Cleric, put a deathtouch counter on it and it becomes a Phyrexian Human Cleric with base power and toughness 3/3.
{1}{B}{B}: If Evolved Sleeper is a Phyrexian, put a +1/+1 counter on it, then you draw a card and you lose 1 life.

Witch's Cottage

({T}: Add {B}.)
Witch's Cottage enters tapped unless you control three or more other Swamps.
When Witch's Cottage enters untapped, you may put target creature card from your graveyard on top of your library.

Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Swamp

Profane Insight

You draw a card and you lose 1 life. (Then exile this card. You may cast the creature later from exile.)