Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Sign in Blood

Target player draws two cards and loses 2 life.

Infectious Horror

Whenever this creature attacks, each opponent loses 2 life.

Taste of Blood

Taste of Blood deals 1 damage to target player or planeswalker and you gain 1 life.

Rotfeaster Maggot

When this creature enters, exile target creature card from a graveyard. You gain life equal to that card's toughness.

Grievous Wound

Enchant player
Enchanted player can't gain life.
Whenever enchanted player is dealt damage, they lose half their life, rounded up.

Render Inert

Remove up to five counters from target permanent.
Draw a card.

The Dross Pits

This land enters tapped.
{T}: Add {B}.
{1}{B}, {T}, Sacrifice this land: Draw a card.

Gray Merchant of Asphodel

When this creature enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Dross Skullbomb

{1}, Sacrifice this artifact: Draw a card.
{2}{B}, Sacrifice this artifact: Return target creature card from your graveyard to your hand. Draw a card. Activate only as a sorcery.

Doomsday Excruciator

Flying
When this creature enters, if it was cast, each player exiles all but the bottom six cards of their library face down.
At the beginning of your upkeep, draw a card.

Spreading Rot

Destroy target land. Its controller loses 2 life.

Fanatic of the Harrowing

When this creature enters, each player discards a card. If you discarded a card this way, draw a card.

Luxa River Shrine

{1}, {T}: You gain 1 life. Put a brick counter on this artifact.
{T}: You gain 2 life. Activate only if there are three or more brick counters on this artifact.

Popular Egotist

{1}{B}, Sacrifice another creature or enchantment: This creature gains indestructible until end of turn. Tap it. (Damage and effects that say "destroy" don't destroy it.)
Whenever you sacrifice a permanent, target opponent loses 1 life and you gain 1 life.

Douse in Gloom

Douse in Gloom deals 2 damage to target creature and you gain 2 life.

Specter of the Fens

Flying
{5}{B}: Target opponent loses 2 life and you gain 2 life.

Urborg Syphon-Mage

{2}{B}, {T}, Discard a card: Each other player loses 2 life. You gain life equal to the life lost this way.

Pharika's Cure

Pharika's Cure deals 2 damage to target creature and you gain 2 life.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• This creature deals 2 damage to any target and you gain 2 life.

Fear of Lost Teeth

When this creature dies, it deals 1 damage to any target and you gain 1 life.

Unholy Hunger

Destroy target creature.
Spell mastery — If there are two or more instant and/or sorcery cards in your graveyard, you gain 2 life.

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When this creature dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Blood-Toll Harpy

Flying
When this creature enters, each player loses 1 life.

Metalspinner's Puzzleknot

When this artifact enters, you draw a card and you lose 1 life.
{2}{B}, Sacrifice this artifact: You draw a card and you lose 1 life.

Grimdancer

This creature enters with your choice of two different counters on it from among menace, deathtouch, and lifelink.

Cruel Grimnarch

Deathtouch
When this creature enters, each opponent discards a card. For each opponent who can't, you gain 4 life.

Etched Familiar

When this creature dies, each opponent loses 2 life and you gain 2 life.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Foul-Tongue Shriek

Target opponent loses 1 life for each attacking creature you control. You gain that much life.

Midnight Assassin

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Tidy Conclusion

Destroy target creature. You gain 1 life for each artifact you control.

Soulcage Fiend

When this creature dies, each player loses 3 life.

Unexpected Fangs

Put a +1/+1 counter and a lifelink counter on target creature.

Offer Immortality

Target creature gains deathtouch and indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Painful Lesson

Absorb Vis

Target player loses 4 life and you gain 4 life.
Basic landcycling {1}{B} ({1}{B}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Bladebrand

Target creature gains deathtouch until end of turn.
Draw a card.

Clawing Torment

Enchant artifact or creature
As long as enchanted permanent is a creature, it gets -1/-1 and can't block.
Enchanted permanent has "At the beginning of your upkeep, you lose 1 life."

Fatal Fumes

Target creature gets -4/-2 until end of turn.

Rug of Smothering

Flying
Whenever a player casts a spell, they lose 1 life for each spell they've cast this turn.

Corrupt

Corrupt deals damage to any target equal to the number of Swamps you control. You gain life equal to the damage dealt this way.

Bloodhunter Bat

Flying
When this creature enters, target player loses 2 life and you gain 2 life.

Depraved Harvester

Desperate Farmer

Lifelink
When another creature you control dies, transform this creature.

Desperate Farmer // Depraved Harvester

Typhoid Rats

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

Fate Unraveler

Whenever an opponent draws a card, this creature deals 1 damage to that player.

Murder

Doom Blade

Rush of Vitality

Target creature gets +1/+0 and gains lifelink and indestructible until end of turn. (Damage dealt by that creature also causes its controller to gain that much life, and it can't be destroyed by damage or effects that say "destroy.")

Prismatic Lens

{T}: Add {C}.
{1}, {T}: Add one mana of any color.

Vampiric Rites

{1}{B}, Sacrifice a creature: You gain 1 life and draw a card.

Bushmeat Poacher

{1}, {T}, Sacrifice another creature: You gain life equal to the sacrificed creature's toughness. Draw a card.

You Are Already Dead

Destroy target creature that was dealt damage this turn.
Draw a card.

Serrated Scorpion

When this creature dies, it deals 2 damage to each opponent and you gain 2 life.

Terramorphic Expanse

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Deathgaze Cockatrice

Nightmare

Flying (This creature can't be blocked except by creatures with flying or reach.)
Nightmare's power and toughness are each equal to the number of Swamps you control.

Quag Sickness

Enchant creature
Enchanted creature gets -1/-1 for each Swamp you control.

Prophetic Prism

When this artifact enters, draw a card.
{1}, {T}: Add one mana of any color.

Evolving Wilds

Suffocating Fumes

Creatures your opponents control get -1/-1 until end of turn.
Cycling {2} ({2}, Discard this card: Draw a card.)

Flesh to Dust

Destroy target creature. It can't be regenerated.

Vrock

Flying
Toxic Spores — At the beginning of your end step, if a permanent you controlled left the battlefield this turn, each opponent loses 3 life.

Wall of Limbs

Defender (This creature can't attack.)
Whenever you gain life, put a +1/+1 counter on this creature.
{5}{B}{B}, Sacrifice this creature: Target player loses X life, where X is this creature's power.

Hemlock Vial

When this artifact enters, you draw a card and you lose 1 life.
{B}, {T}, Sacrifice this artifact: Each equipped creature and Equipment you control gains deathtouch until end of turn.

Angel's Feather

Whenever a player casts a white spell, you may gain 1 life.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Merciless Executioner

When this creature enters, each player sacrifices a creature of their choice.

Phyrexian Gargantua

When this creature enters, you draw two cards and you lose 2 life.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice this artifact: Draw a card.

Circuit Mender

When this creature enters, you gain 2 life.
When this creature leaves the battlefield, draw a card.

Swamp

Golden Urn

At the beginning of your upkeep, you may put a charge counter on this artifact.
{T}, Sacrifice this artifact: You gain life equal to the number of charge counters on this artifact.

Reaper's Talisman

Whenever equipped creature attacks, it gains deathtouch until end of turn.
Whenever equipped creature attacks alone, defending player loses 2 life and you gain 2 life.
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Agent of the Iron Throne

Commander creatures you own have "Whenever an artifact or creature you control is put into a graveyard from the battlefield, each opponent loses 1 life."

Phyrexian Rager

When this creature enters, you draw a card and you lose 1 life.

Sol Ring

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Gruesome Realization

Choose one —
• You draw two cards and you lose 2 life.
• Creatures your opponents control get -1/-1 until end of turn.

Covenant of Blood

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Covenant of Blood deals 4 damage to any target and you gain 4 life.

Stab Wound

Enchant creature
Enchanted creature gets -2/-2.
At the beginning of the upkeep of enchanted creature's controller, that player loses 2 life.