Reject Imperfection

Counter target spell. If that spell's mana value was 3 or less, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Distorted Curiosity

Corrupted — This spell costs {2} less to cast if an opponent has three or more poison counters.
Draw two cards.

Tamiyo's Safekeeping

Target permanent you control gains hexproof and indestructible until end of turn. You gain 2 life. (A permanent with hexproof and indestructible can't be the target of spells or abilities your opponents control. Damage and effects that say "destroy" don't destroy it.)

Ivy, Gleeful Spellthief

Flying
Whenever a player casts a spell that targets only a single creature other than Ivy, Gleeful Spellthief, you may copy that spell. The copy targets Ivy. (A copy of an Aura spell becomes a token.)

Shore Up

Target creature you control gets +1/+1 and gains hexproof until end of turn. Untap it. (It can't be the target of spells or abilities your opponents control.)

Venerated Rotpriest

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Whenever a creature you control becomes the target of a spell, target opponent gets a poison counter.

Island

Mirrex

{T}: Add {C}.
{T}: Add one mana of any color. Activate only if Mirrex entered this turn.
{3}, {T}: Create a 1/1 colorless Phyrexian Mite artifact creature token with toxic 1 and "This creature can't block." (Players dealt combat damage by it also get a poison counter.)

Bring the Ending

Counter target spell unless its controller pays {2}.
Corrupted — Counter that spell instead if its controller has three or more poison counters.

Experimental Augury

Look at the top three cards of your library. Put one of them into your hand and the rest on the bottom of your library in any order. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Prologue to Phyresis

Each opponent gets a poison counter.
Draw a card.

Slip Out the Back

Put a +1/+1 counter on target creature. It phases out. (Treat it and anything attached to it as though they don't exist until its controller's next turn.)

Bloated Contaminator

Trample
Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Whenever Bloated Contaminator deals combat damage to a player, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Otawara, Soaring City

{T}: Add {U}.
Channel — {3}{U}, Discard Otawara, Soaring City: Return target artifact, creature, enchantment, or planeswalker to its owner's hand. This ability costs {1} less to activate for each legendary creature you control.

The Seedcore

{T}: Add {C}.
{T}: Add one mana of any color. Spend this mana only to cast Phyrexian creature spells.
Corrupted — {T}: Target 1/1 creature gets +2/+1 until end of turn. Activate only if an opponent has three or more poison counters.

Yavimaya Coast

{T}: Add {C}.
{T}: Add {G} or {U}. Yavimaya Coast deals 1 damage to you.

Stormchaser Drake

Flying
Whenever Stormchaser Drake becomes the target of a spell you control, draw a card.

Tyvar's Stand

Target creature you control gets +X/+X and gains hexproof and indestructible until end of turn. (A creature with hexproof and indestructible can't be the target of spells or abilities your opponents control. Damage and effects that say "destroy" don't destroy it.)

Dreamroot Cascade

Dreamroot Cascade enters tapped unless you control two or more other lands.
{T}: Add {G} or {U}.