Marchesa's Infiltrator

Dethrone (Whenever this creature attacks the player with the most life or tied for most life, put a +1/+1 counter on it.)
Whenever Marchesa's Infiltrator deals combat damage to a player, draw a card.

Essence Bottle

{3}, {T}: Put an elixir counter on Essence Bottle.
{T}, Remove all elixir counters from Essence Bottle: You gain 2 life for each elixir counter removed this way.

Punishing Fire

Punishing Fire deals 2 damage to any target.
Whenever an opponent gains life, you may pay {R}. If you do, return Punishing Fire from your graveyard to your hand.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Pyrite Spellbomb

{R}, Sacrifice Pyrite Spellbomb: It deals 2 damage to any target.
{1}, Sacrifice Pyrite Spellbomb: Draw a card.

Surge Engine

Defender
{U}: Surge Engine loses defender and gains "This creature can't be blocked."
{2}{U}: Surge Engine becomes blue and has base power and toughness 5/4. Activate only if Surge Engine doesn't have defender.
{4}{U}{U}: Draw three cards. Activate only if Surge Engine is blue and only once.

Myriad Landscape

Myriad Landscape enters the battlefield tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Scavenger Grounds

{T}: Add {C}.
{2}, {T}, Sacrifice a Desert: Exile all graveyards.

Treasure Mage

When Treasure Mage enters the battlefield, you may search your library for an artifact card with mana value 6 or greater, reveal it, put it into your hand, then shuffle.

Mishra's Bauble

{T}, Sacrifice Mishra's Bauble: Look at the top card of target player's library. Draw a card at the beginning of the next turn's upkeep.

Mazemind Tome

{T}, Put a page counter on Mazemind Tome: Scry 1.
{2}, {T}, Put a page counter on Mazemind Tome: Draw a card.
When there are four or more page counters on Mazemind Tome, exile it. If you do, you gain 4 life.

Zur's Weirding

Players play with their hands revealed.
If a player would draw a card, they reveal it instead. Then any other player may pay 2 life. If a player does, put that card into its owner's graveyard. Otherwise, that player draws a card.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Malignus

Malignus's power and toughness are each equal to half the highest life total among your opponents, rounded up.
Damage that would be dealt by Malignus can't be prevented.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Tawnos, Urza's Apprentice

Haste
{U}{R}, {T}: Copy target activated or triggered ability you control from an artifact source. You may choose new targets for the copy. (Mana abilities can't be targeted.)

Treasonous Ogre

Dethrone (Whenever this creature attacks the player with the most life or tied for most life, put a +1/+1 counter on it.)
Pay 3 life: Add {R}.

An Offer You Can't Refuse

Counter target noncreature spell. Its controller creates two Treasure tokens. (They're artifacts with "{T}, Sacrifice this artifact: Add one mana of any color.")

Orazca Relic

Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
{T}: Add {C}.
{T}, Sacrifice Orazca Relic: You gain 3 life and draw a card. Activate only if you have the city's blessing.

Flames of the Blood Hand

Flames of the Blood Hand deals 4 damage to target player or planeswalker. The damage can't be prevented. If that player or that planeswalker's controller would gain life this turn, that player gains no life instead.

Phyrexian Processor

As Phyrexian Processor enters the battlefield, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as Phyrexian Processor entered the battlefield.

Druidic Satchel

{2}, {T}: Reveal the top card of your library. If it's a creature card, create a 1/1 green Saproling creature token. If it's a land card, put that card onto the battlefield under your control. If it's a noncreature, nonland card, you gain 2 life.

Embargo

Nonland permanents don't untap during their controllers' untap steps.
At the beginning of your upkeep, you lose 2 life.

Spire of Industry

{T}: Add {C}.
{T}, Pay 1 life: Add one mana of any color. Activate only if you control an artifact.

Goblin Replica

{3}{R}, Sacrifice Goblin Replica: Destroy target artifact.

Trading Post

{1}, {T}, Discard a card: You gain 4 life.
{1}, {T}, Pay 1 life: Create a 0/1 white Goat creature token.
{1}, {T}, Sacrifice a creature: Return target artifact card from your graveyard to your hand.
{1}, {T}, Sacrifice an artifact: Draw a card.

Artificer's Intuition

{U}, Discard an artifact card: Search your library for an artifact card with mana value 1 or less, reveal it, put it into your hand, then shuffle.

Arcane Denial

Counter target spell. Its controller may draw up to two cards at the beginning of the next turn's upkeep.
You draw a card at the beginning of the next turn's upkeep.

Counterspell

Treasure Vault

{T}: Add {C}.
{X}{X}, {T}, Sacrifice Treasure Vault: Create X Treasure tokens.

Sol Ring

Strionic Resonator

{2}, {T}: Copy target triggered ability you control. You may choose new targets for the copy. (A triggered ability uses the words "when," "whenever," or "at.")

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Surgical Skullbomb

{1}, Sacrifice Surgical Skullbomb: Draw a card.
{2}{U}, Sacrifice Surgical Skullbomb: Return target creature to its owner's hand. Draw a card. Activate only as a sorcery.

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform Chalice of Life.

Chalice of Life // Chalice of Death

Urza's Chalice

Whenever a player casts an artifact spell, you may pay {1}. If you do, you gain 1 life.

War Room

{T}: Add {C}.
{3}, {T}, Pay life equal to the number of colors in your commanders' color identity: Draw a card.

Mnemonic Sphere

{1}{U}, Sacrifice Mnemonic Sphere: Draw two cards.
Channel — {U}, Discard Mnemonic Sphere: Draw a card.

Aria of Flame

When Aria of Flame enters the battlefield, each opponent gains 10 life.
Whenever you cast an instant or sorcery spell, put a verse counter on Aria of Flame, then it deals damage equal to the number of verse counters on it to target player or planeswalker.

Kurkesh, Onakke Ancient

Whenever you activate an ability of an artifact, if it isn't a mana ability, you may pay {R}. If you do, copy that ability. You may choose new targets for the copy.

Dungeoneer's Pack

Dungeoneer's Pack enters the battlefield tapped.
{2}, {T}, Sacrifice Dungeoneer's Pack: You take the initiative, gain 3 life, draw a card, and create a Treasure token. Activate only as a sorcery. (A Treasure token is an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Meteor Golem

When Meteor Golem enters the battlefield, destroy target nonland permanent an opponent controls.

Silverbluff Bridge

Silverbluff Bridge enters the battlefield tapped.
Indestructible
{T}: Add {U} or {R}.

Hall of Tagsin

{T}: Add {C}.
{1}, {T}: Add one mana of any color.
{4}, {T}: Create a tapped Powerstone token. (It's an artifact with "{T}: Add {C}. This mana can't be spent to cast a nonartifact spell.")

Dack's Duplicate

You may have Dack's Duplicate enter the battlefield as a copy of any creature on the battlefield, except it has haste and dethrone. (Whenever it attacks the player with the most life or tied for most life, put a +1/+1 counter on it.)

Great Furnace

Courier's Capsule

{1}{U}, {T}, Sacrifice Courier's Capsule: Draw two cards.

Mirror Universe

{T}, Sacrifice Mirror Universe: Exchange life totals with target opponent. Activate only during your upkeep.

Elixir of Immortality

{2}, {T}: You gain 5 life. Shuffle Elixir of Immortality and your graveyard into their owner's library.

Lithoform Engine

{2}, {T}: Copy target activated or triggered ability you control. You may choose new targets for the copy.
{3}, {T}: Copy target instant or sorcery spell you control. You may choose new targets for the copy.
{4}, {T}: Copy target permanent spell you control. (The copy becomes a token.)

Profane Memento

Whenever a creature card is put into an opponent's graveyard from anywhere, you gain 1 life.

Golem's Heart

Whenever a player casts an artifact spell, you may gain 1 life.

Shivan Reef

{T}: Add {C}.
{T}: Add {U} or {R}. Shivan Reef deals 1 damage to you.

Transmogrifying Wand

Transmogrifying Wand enters the battlefield with three charge counters on it.
{1}, {T}, Remove a charge counter from Transmogrifying Wand: Destroy target creature. Its controller creates a 2/4 white Ox creature token. Activate only as a sorcery.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Rug of Smothering

Flying
Whenever a player casts a spell, they lose 1 life for each spell they've cast this turn.

Sanctum of the Sun

(Transforms from Azor's Gateway.)
{T}: Add X mana of any one color, where X is your life total.

Azor's Gateway

{1}, {T}: Draw a card, then exile a card from your hand. If cards with five or more different mana values are exiled with Azor's Gateway, you gain 5 life, untap Azor's Gateway, and transform it.

Azor's Gateway // Sanctum of the Sun

Fabricate

Search your library for an artifact card, reveal it, put it into your hand, then shuffle.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Mountain

Lux Cannon

{T}: Put a charge counter on Lux Cannon.
{T}, Remove three charge counters from Lux Cannon: Destroy target permanent.

Pristine Talisman

Burnished Hart

{3}, Sacrifice Burnished Hart: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Unstable Obelisk

{T}: Add {C}.
{7}, {T}, Sacrifice Unstable Obelisk: Destroy target permanent.

Delusions of Mediocrity

When Delusions of Mediocrity enters the battlefield, you gain 10 life.
When Delusions of Mediocrity leaves the battlefield, you lose 10 life.

Seat of the Synod

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Volcano Hellion

Volcano Hellion has echo {X}, where X is your life total. (At the beginning of your upkeep, if this came under your control since the beginning of your last upkeep, sacrifice it unless you pay its echo cost.)
When Volcano Hellion enters the battlefield, it deals an amount of damage of your choice to you and target creature. The damage can't be prevented.

Golden Urn

At the beginning of your upkeep, you may put a charge counter on Golden Urn.
{T}, Sacrifice Golden Urn: You gain life equal to the number of charge counters on Golden Urn.

Elixir of Vitality

Elixir of Vitality enters the battlefield tapped.
{T}, Sacrifice Elixir of Vitality: You gain 4 life.
{8}, {T}, Sacrifice Elixir of Vitality: You gain 8 life.

Island

Aether Spellbomb

{U}, Sacrifice Aether Spellbomb: Return target creature to its owner's hand.
{1}, Sacrifice Aether Spellbomb: Draw a card.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Glacial Chasm

Cumulative upkeep—Pay 2 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
When Glacial Chasm enters the battlefield, sacrifice a land.
Creatures you control can't attack.
Prevent all damage that would be dealt to you.

Tower of Eons

Fountain of Renewal

At the beginning of your upkeep, you gain 1 life.
{3}, Sacrifice Fountain of Renewal: Draw a card.