Alms of the Vein

Target opponent loses 3 life and you gain 3 life.
Madness {B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Proxy or wait for price down plop

Game of Chaos

Flip a coin. If you win the flip, you gain 1 life and target opponent loses 1 life, and you decide whether to flip again. If you lose the flip, you lose 1 life and that opponent gains 1 life, and that player decides whether to flip again. Double the life stakes with each flip.

Vindictive Lich

When Vindictive Lich dies, choose one or more. Each mode must target a different player.
• Target opponent sacrifices a creature of their choice.
• Target opponent discards two cards.
• Target opponent loses 5 life.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Flaring Pain

Damage can't be prevented this turn.
Flashback {R} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Cuombajj Witches

{T}: Cuombajj Witches deals 1 damage to any target and 1 damage to any target of an opponent's choice.

Chancellor of the Dross

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent loses 3 life, then you gain life equal to the life lost this way.
Flying, lifelink

Chancellor of the Forge

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, create a 1/1 red Phyrexian Goblin creature token with haste.
When Chancellor of the Forge enters, create X 1/1 red Phyrexian Goblin creature tokens with haste, where X is the number of creatures you control.

Hierophant's Chalice

When Hierophant's Chalice enters, target opponent loses 1 life and you gain 1 life.
{T}: Add {C}.

Exava, Rakdos Blood Witch

First strike, haste
Unleash (You may have this creature enter with a +1/+1 counter on it. It can't block as long as it has a +1/+1 counter on it.)
Each other creature you control with a +1/+1 counter on it has haste.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Lightning Bolt

Lightning Bolt deals 3 damage to any target.

Ravenloft Adventurer

When Ravenloft Adventurer enters, you take the initiative.
If a creature an opponent controls would die, instead exile it and put a hit counter on it.
Whenever Ravenloft Adventurer attacks, if you've completed a dungeon, defending player loses 1 life for each card they own in exile with a hit counter on it.

Timesifter

At the beginning of each upkeep, each player exiles the top card of their library. The player who exiled the card with the highest mana value takes an extra turn after this one. If two or more players' cards are tied for highest, the tied players repeat this process until the tie is broken.

Glittering Stockpile

{T}: Add {R}. Put a stash counter on Glittering Stockpile.
{T}, Sacrifice Glittering Stockpile: Add X mana of any one color, where X is the number of stash counters on Glittering Stockpile.

Shadow Slice

Target opponent loses 3 life.
Cipher (Then you may exile this spell card encoded on a creature you control. Whenever that creature deals combat damage to a player, its controller may cast a copy of the encoded card without paying its mana cost.)

Collective Brutality

Escalate—Discard a card. (Pay this cost for each mode chosen beyond the first.)
Choose one or more —
• Target opponent reveals their hand. You choose an instant or sorcery card from it. That player discards that card.
• Target creature gets -2/-2 until end of turn.
• Target opponent loses 2 life and you gain 2 life.

Death Cloud

Each player loses X life, discards X cards, sacrifices X creatures of their choice, then sacrifices X lands of their choice.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Remorseless Punishment

Target opponent loses 5 life unless that player discards two cards or sacrifices a creature or planeswalker of their choice. Repeat this process once.

Shard of the Nightbringer

Flying
Drain Life — When Shard of the Nightbringer enters, if you cast it, target opponent loses half their life, rounded up. You gain life equal to the life lost this way.

Grim Reminder

Search your library for a nonland card and reveal it. Each opponent who cast a spell this turn with the same name as that card loses 6 life. Then shuffle.
{B}{B}: Return Grim Reminder from your graveyard to your hand. Activate only during your upkeep.

Death's Shadow

Death's Shadow gets -X/-X, where X is your life total.

Mountain

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Dakmor Ghoul

When Dakmor Ghoul enters, target opponent loses 2 life and you gain 2 life.

Choice of Damnations

Target opponent chooses a number. You may have that player lose that much life. If you don't, that player sacrifices all but that many permanents of their choice.

Scythe Specter

Flying
Whenever Scythe Specter deals combat damage to a player, each opponent discards a card. Each player who discarded a card with the highest mana value among cards discarded this way loses life equal to that mana value.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Scourge of the Skyclaves

Kicker {4}{B}
When you cast this spell, if it was kicked, each player loses half their life, rounded up.
Scourge of the Skyclaves's power and toughness are each equal to 20 minus the highest life total among players.

Blood Tribute

Kicker—Tap an untapped Vampire you control. (You may tap a Vampire you control in addition to any other costs as you cast this spell.)
Target opponent loses half their life, rounded up. If this spell was kicked, you gain life equal to the life lost this way.

Decimator Web

{4}, {T}: Target opponent loses 2 life, gets a poison counter, then mills six cards.

Invoke Despair

Target opponent sacrifices a creature of their choice. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Plague Drone

Flying
Rot Fly — If an opponent would gain life, that player loses that much life instead.

Ribbons

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Each opponent loses X life.

Cut // Ribbons

Measure of Wickedness

At the beginning of your end step, sacrifice Measure of Wickedness and you lose 8 life.
Whenever another card is put into your graveyard from anywhere, target opponent gains control of Measure of Wickedness.

Dark Suspicions

At the beginning of each opponent's upkeep, that player loses X life, where X is the number of cards in that player's hand minus the number of cards in your hand.

Bump in the Night

Target opponent loses 3 life.
Flashback {5}{R} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Hellish Rebuke

Until end of turn, permanents your opponents control gain "When this permanent deals damage to the player who cast Hellish Rebuke, sacrifice this permanent. You lose 2 life."

Cabal Ritual

Add {B}{B}{B}.
Threshold — Add {B}{B}{B}{B}{B} instead if seven or more cards are in your graveyard.

Blood for the Blood God!

This spell costs {1} less to cast for each creature that died this turn.
Discard your hand, then draw eight cards. Blood for the Blood God! deals 8 damage to each opponent. Exile Blood for the Blood God!

Geralf's Messenger

Geralf's Messenger enters tapped.
When Geralf's Messenger enters, target opponent loses 2 life.
Undying (When this creature dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Vampire Spawn

When this creature enters, each opponent loses 2 life and you gain 2 life.

Leechridden Swamp

({T}: Add {B}.)
Leechridden Swamp enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Prying Questions

Target opponent loses 3 life and puts a card from their hand on top of their library.

Dark Ritual

Tattered Mummy

When Tattered Mummy dies, each opponent loses 2 life.

Brush with Death

Buyback {2}{B}{B} (You may pay an additional {2}{B}{B} as you cast this spell. If you do, put this card into your hand as it resolves.)
Target opponent loses 2 life. You gain 2 life.

Shadows of the Past

Whenever a creature dies, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{4}{B}: Each opponent loses 2 life and you gain 2 life. Activate only if there are four or more creature cards in your graveyard.

Leyline of Punishment

If Leyline of Punishment is in your opening hand, you may begin the game with it on the battlefield.
Players can't gain life.
Damage can't be prevented.

The Ruinous Powers

At the beginning of your upkeep, choose an opponent at random. Exile the top card of that player's library. Until end of turn, you may play that card and you may spend mana as though it were mana of any color to cast it. When you cast a spell this way, its owner loses life equal to its mana value.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Snow-Covered Swamp

Nightshade Harvester

Whenever a land an opponent controls enters, that player loses 1 life. Put a +1/+1 counter on Nightshade Harvester.

Have

Ob Nixilis, the Fallen

Landfall — Whenever a land you control enters, you may have target player lose 3 life. If you do, put three +1/+1 counters on Ob Nixilis, the Fallen.

Great Unclean One

Reverberating Summons — At the beginning of your end step, each opponent loses 2 life. Then for each opponent who has less life than you, create a 1/3 black Demon creature token named Plaguebearer of Nurgle.

Aurora of Emrakul

Flying, deathtouch
Whenever Aurora of Emrakul attacks, each opponent loses 3 life.

Cryptolith Fragment

Cryptolith Fragment enters tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform Cryptolith Fragment.

Cryptolith Fragment // Aurora of Emrakul

Stomp

Damage can't be prevented this turn. Stomp deals 2 damage to any target.

Bonecrusher Giant

Whenever Bonecrusher Giant becomes the target of a spell, Bonecrusher Giant deals 2 damage to that spell's controller.

Bonecrusher Giant // Stomp

Subversion

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Empowered Autogenerator

Empowered Autogenerator enters tapped.
{T}: Put a charge counter on Empowered Autogenerator. Add X mana of any one color, where X is the number of charge counters on Empowered Autogenerator.

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Starscream, Seeker Leader

Living metal (During your turn, this Vehicle is also a creature.)
Flying, menace, haste
Whenever Starscream deals combat damage to a player, if there is no monarch, that player becomes the monarch.
Whenever you become the monarch, convert Starscream.

Starscream, Power Hungry

More Than Meets the Eye {2}{B} (You may cast this card converted for {2}{B}.)
Flying
Whenever you draw a card, if you're the monarch, target opponent loses 2 life.
Whenever one or more creatures deal combat damage to you, convert Starscream.