Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Magus of the Wheel

{1}{R}, {T}, Sacrifice Magus of the Wheel: Each player discards their hand, then draws seven cards.

Phyrexian Gargantua

When Phyrexian Gargantua enters, you draw two cards and you lose 2 life.

Spiteful Visions

At the beginning of each player's draw step, that player draws an additional card.
Whenever a player draws a card, Spiteful Visions deals 1 damage to that player.

Stinging Study

You draw X cards and you lose X life, where X is the mana value of a commander you own on the battlefield or in the command zone.

Tsabo's Web

When Tsabo's Web enters, draw a card.
Each land with an activated ability that isn't a mana ability doesn't untap during its controller's untap step.

Florian, Voldaren Scion

First strike
At the beginning of each of your postcombat main phases, look at the top X cards of your library, where X is the total amount of life your opponents lost this turn. Exile one of those cards and put the rest on the bottom of your library in a random order. You may play the exiled card this turn.

Anax, Hardened in the Forge

Anax's power is equal to your devotion to red. (Each {R} in the mana costs of permanents you control counts toward your devotion to red.)
Whenever Anax or another nontoken creature you control dies, create a 1/1 red Satyr creature token with "This creature can't block." If the creature had power 4 or greater, create two of those tokens instead.

Mayhem Devil

Whenever a player sacrifices a permanent, Mayhem Devil deals 1 damage to any target.

Spellshock

Whenever a player casts a spell, Spellshock deals 2 damage to that player.

Greed

Tsabo's Assassin

{T}: Destroy target creature if it shares a color with the most common color among all permanents or a color tied for most common. A creature destroyed this way can't be regenerated.

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Visara the Dreadful

Flying
{T}: Destroy target creature. It can't be regenerated.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Kardur, Doomscourge

When Kardur, Doomscourge enters, until your next turn, creatures your opponents control attack each combat if able and attack a player other than you if able.
Whenever an attacking creature dies, each opponent loses 1 life and you gain 1 life.

Phyrexian Grimoire

{4}, {T}: Target opponent chooses one of the top two cards of your graveyard. Exile that card and put the other one into your hand.

Sin Prodder

Menace
At the beginning of your upkeep, reveal the top card of your library. Any opponent may have you put that card into your graveyard. If a player does, Sin Prodder deals damage to that player equal to that card's mana value. Otherwise, put that card into your hand.

Dragon Mage

Flying
Whenever this creature deals combat damage to a player, each player discards their hand, then draws seven cards.

Cryptborn Horror

Trample
Cryptborn Horror enters with X +1/+1 counters on it, where X is the total life lost by your opponents this turn.

Lethal Vapors

Whenever a creature enters, destroy it.
{0}: Destroy Lethal Vapors. You skip your next turn. Any player may activate this ability.

Spreading Plague

Whenever a creature enters, destroy all other creatures that share a color with it. They can't be regenerated.

Terminate

Destroy target creature. It can't be regenerated.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Sulfuric Vortex

At the beginning of each player's upkeep, Sulfuric Vortex deals 2 damage to that player.
If a player would gain life, that player gains no life instead.

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Phyrexian Rager

When Phyrexian Rager enters, you draw a card and you lose 1 life.

Plaguecrafter

When Plaguecrafter enters, each player sacrifices a creature or planeswalker of their choice. Each player who can't discards a card.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Tragic Slip

Target creature gets -1/-1 until end of turn.
Morbid — That creature gets -13/-13 until end of turn instead if a creature died this turn.

Lagomos, Hand of Hatred

At the beginning of combat on your turn, create a 2/1 red Elemental creature token with trample and haste. Sacrifice it at the beginning of the next end step.
{T}: Search your library for a card, put it into your hand, then shuffle. Activate only if five or more creatures died this turn.

Urabrask the Hidden

Creatures you control have haste.
Creatures your opponents control enter tapped.

Doomed Necromancer

{B}, {T}, Sacrifice Doomed Necromancer: Return target creature card from your graveyard to the battlefield.

Yawgmoth's Agenda

You can't cast more than one spell each turn.
You may play lands and cast spells from your graveyard.
If a card would be put into your graveyard from anywhere, exile it instead.

Mountain

Dictate of the Twin Gods

Flash
If a source would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Gonti, Lord of Luxury

Deathtouch
When Gonti, Lord of Luxury enters, look at the top four cards of target opponent's library, exile one of them face down, then put the rest on the bottom of that library in a random order. You may cast that card for as long as it remains exiled, and mana of any type can be spent to cast that spell.

Molten Slagheap

{T}: Add {C}.
{1}, {T}: Put a storage counter on Molten Slagheap.
{1}, Remove X storage counters from Molten Slagheap: Add X mana in any combination of {B} and/or {R}.

Sudden Spoiling

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Until end of turn, creatures target player controls lose all abilities and have base power and toughness 0/2.

Sire of Insanity

At the beginning of each end step, each player discards their hand.

Zo-Zu the Punisher

Whenever a land enters, Zo-Zu the Punisher deals 2 damage to that land's controller.

Archfiend of Depravity

Flying
At the beginning of each opponent's end step, that player chooses up to two creatures they control, then sacrifices the rest.

Everlasting Torment

Players can't gain life.
Damage can't be prevented.
All damage is dealt as though its source had wither. (A source with wither deals damage to creatures in the form of -1/-1 counters.)

Phyrexian Processor

As Phyrexian Processor enters, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as Phyrexian Processor entered.

Phyrexian Delver

When Phyrexian Delver enters, return target creature card from your graveyard to the battlefield. You lose life equal to that card's mana value.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Ravenous Chupacabra

When Ravenous Chupacabra enters, destroy target creature an opponent controls.

Swamp

Lava Zombie

When Lava Zombie enters, return a black or red creature you control to its owner's hand.
{2}: Lava Zombie gets +1/+0 until end of turn.

Pain Magnification

Whenever an opponent is dealt 3 or more damage by a single source, that player discards a card.

Pestilence

At the beginning of the end step, if no creatures are on the battlefield, sacrifice Pestilence.
{B}: Pestilence deals 1 damage to each creature and each player.

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Dread

Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
Whenever a creature deals damage to you, destroy it.
When Dread is put into a graveyard from anywhere, shuffle it into its owner's library.

Harsh Mentor

Whenever an opponent activates an ability of an artifact, creature, or land on the battlefield, if it isn't a mana ability, Harsh Mentor deals 2 damage to that player.

Bellowing Mauler

At the beginning of your end step, each player loses 4 life unless they sacrifice a nontoken creature of their choice.

Manabarbs

Whenever a player taps a land for mana, Manabarbs deals 1 damage to that player.

Burnished Hart

{3}, Sacrifice this creature: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Leyline of Combustion

If Leyline of Combustion is in your opening hand, you may begin the game with it on the battlefield.
Whenever you and/or at least one permanent you control becomes the target of a spell or ability an opponent controls, Leyline of Combustion deals 2 damage to that player.

Indulgent Tormentor

Flying
At the beginning of your upkeep, draw a card unless target opponent sacrifices a creature of their choice or pays 3 life.

Stormfist Crusader

Menace
At the beginning of your upkeep, each player draws a card and loses 1 life.

Reassembling Skeleton

{1}{B}: Return this card from your graveyard to the battlefield tapped.

Tectonic Giant

Whenever Tectonic Giant attacks or becomes the target of a spell an opponent controls, choose one —
• Tectonic Giant deals 3 damage to each opponent.
• Exile the top two cards of your library. Choose one of them. Until the end of your next turn, you may play that card.

Theater of Horrors

At the beginning of your upkeep, exile the top card of your library.
During your turn, if an opponent lost life this turn, you may play lands and cast spells from among cards exiled with Theater of Horrors.
{3}{R}: Theater of Horrors deals 1 damage to target opponent or planeswalker.

Tsabo Tavoc

First strike, protection from legendary creatures
{B}{B}, {T}: Destroy target legendary creature. It can't be regenerated.

Fleshbag Marauder

When Fleshbag Marauder enters, each player sacrifices a creature of their choice.

Great Unclean One

Reverberating Summons — At the beginning of your end step, each opponent loses 2 life. Then for each opponent who has less life than you, create a 1/3 black Demon creature token named Plaguebearer of Nurgle.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.