Afterlife

Destroy target creature. It can't be regenerated. Its controller creates a 1/1 white Spirit creature token with flying.

Obelisk of Esper

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Talisman of Dominance

{T}: Add {C}.
{T}: Add {U} or {B}. Talisman of Dominance deals 1 damage to you.

Manalith

Aether Snap

Remove all counters from all permanents and exile all tokens.

Murder

Sisay's Ring

Sol Ring

Annul

Counter target artifact or enchantment spell.

Darksteel Ingot

Indestructible (Effects that say "destroy" don't destroy this artifact.)
{T}: Add one mana of any color.

Mortify

Disenchant

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Life's Finale

Destroy all creatures, then search target opponent's library for up to three creature cards and put them into their graveyard. Then that player shuffles.

Dingus Staff

Whenever a creature dies, Dingus Staff deals 2 damage to that creature's controller.

Counterspell

Talisman of Progress

{T}: Add {C}.
{T}: Add {W} or {U}. Talisman of Progress deals 1 damage to you.

Marble Diamond

Marble Diamond enters tapped.
{T}: Add {W}.

Dispersal Shield

Counter target spell if its mana value is less than or equal to the highest mana value among permanents you control.

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Evacuation

Return all creatures to their owners' hands.

Utter End

Orzhov Signet

Charcoal Diamond

Charcoal Diamond enters tapped.
{T}: Add {B}.

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Rewind

Counter target spell. Untap up to four lands.

Doom Blade

Divine Reckoning

Each player chooses a creature they control. Destroy the rest.
Flashback {5}{W}{W} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Extinguish All Hope

Negate

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Chromium

Flying
Rampage 2 (Whenever this creature becomes blocked, it gets +2/+2 until end of turn for each creature blocking it beyond the first.)
At the beginning of your upkeep, sacrifice Chromium unless you pay {W}{U}{B}.