Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Torture

Enchant creature
{1}{B}: Put a -1/-1 counter on enchanted creature.

Hero's Downfall

Pestilent Souleater

{B/P}: Pestilent Souleater gains infect until end of turn. ({B/P} can be paid with either {B} or 2 life. A creature with infect deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Phyrexian Vivisector

Whenever a creature you control dies, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Stuffy Doll

Indestructible
As Stuffy Doll enters, choose a player.
Whenever Stuffy Doll is dealt damage, it deals that much damage to the chosen player.
{T}: Stuffy Doll deals 1 damage to itself.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Tower of Eons

Phyrexia's Core

{T}: Add {C}.
{1}, {T}, Sacrifice an artifact: You gain 1 life.

Grafted Exoskeleton

Equipped creature gets +2/+2 and has infect. (It deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Whenever Grafted Exoskeleton becomes unattached from a permanent, sacrifice that permanent.
Equip {2}

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform Chalice of Life.

Chalice of Life // Chalice of Death

Sudden Spoiling

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Until end of turn, creatures target player controls lose all abilities and have base power and toughness 0/2.

Vexing Puzzlebox

Whenever you roll one or more dice, put a number of charge counters on Vexing Puzzlebox equal to the result.
{T}: Add one mana of any color. Roll a d20.
{T}, Remove 100 charge counters from Vexing Puzzlebox: Search your library for an artifact card, put that card onto the battlefield, then shuffle.

Swamp

Stronghold Assassin

{T}, Sacrifice a creature: Destroy target nonblack creature.

Phyrexian Splicer

{2}, {T}, Choose flying, first strike, trample, or shadow: Until end of turn, target creature with the chosen ability loses it and another target creature gains it.

Grindclock

{T}: Put a charge counter on Grindclock.
{T}: Target player mills X cards, where X is the number of charge counters on Grindclock.

Mindslaver

{4}, {T}, Sacrifice Mindslaver: You control target player during that player's next turn. (You see all cards that player could see and make all decisions for the player.)

Darksteel Forge

Artifacts you control have indestructible. (Effects that say "destroy" don't destroy them. Artifact creatures with indestructible can't be destroyed by damage.)

Chainer's Edict

Target player sacrifices a creature.
Flashback {5}{B}{B} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Commander's Plate

Equipped creature gets +3/+3 and has protection from each color that's not in your commander's color identity.
Equip commander {3}
Equip {5}

Yawgmoth's Vile Offering

(You may cast a legendary sorcery only if you control a legendary creature or planeswalker.)
Put up to one target creature or planeswalker card from a graveyard onto the battlefield under your control. Destroy up to one target creature or planeswalker. Exile Yawgmoth's Vile Offering.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Contagion Engine

When Contagion Engine enters, put a -1/-1 counter on each creature target player controls.
{4}, {T}: Proliferate twice. (Choose any number of permanents and/or players, then give each another counter of each kind already there. Then do it again.)

Dark Ritual

Geth, Lord of the Vault

Intimidate (This creature can't be blocked except by artifact creatures and/or creatures that share a color with it.)
{X}{B}: Put target artifact or creature card with mana value X from an opponent's graveyard onto the battlefield under your control tapped. Then that player mills X cards.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Caress of Phyrexia

Target player draws three cards, loses 3 life, and gets three poison counters.

Phyrexian Digester

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Priest of Gix

When Priest of Gix enters, add {B}{B}{B}.

Phyrexian Bloodstock

When Phyrexian Bloodstock leaves the battlefield, destroy target white creature. It can't be regenerated.

Keening Stone

{5}, {T}: Target player mills X cards, where X is the number of cards in that player's graveyard.

Gnarled Effigy

{4}, {T}: Put a -1/-1 counter on target creature.

Phyrexian Defiler

{T}, Sacrifice Phyrexian Defiler: Target creature gets -3/-3 until end of turn.

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature.

Phyrexian Scriptures

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Put a +1/+1 counter on up to one target creature. That creature becomes an artifact in addition to its other types.
II — Destroy all nonartifact creatures.
III — Exile all opponents' graveyards.

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Aligned Hedron Network

When Aligned Hedron Network enters, exile all creatures with power 5 or greater until Aligned Hedron Network leaves the battlefield. (Those creatures return under their owners' control.)

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Blind Zealot

Intimidate (This creature can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever Blind Zealot deals combat damage to a player, you may sacrifice it. If you do, destroy target creature that player controls.

Darksteel Reactor

Indestructible (Effects that say "destroy" don't destroy this artifact.)
At the beginning of your upkeep, you may put a charge counter on Darksteel Reactor.
When Darksteel Reactor has twenty or more charge counters on it, you win the game.

Commander Greven il-Vec

Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
When Commander Greven il-Vec enters, sacrifice a creature.

Wheel of Torture

At the beginning of each opponent's upkeep, Wheel of Torture deals X damage to that player, where X is 3 minus the number of cards in their hand.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Yawgmoth's Edict

Whenever an opponent casts a white spell, that player loses 1 life and you gain 1 life.

Keskit, the Flesh Sculptor

{T}, Sacrifice three other artifacts and/or creatures: Look at the top three cards of your library. Put two of them into your hand and the other into your graveyard.
Partner (You can have two commanders if both have partner.)

Dreamstone Hedron

{T}: Add {C}{C}{C}.
{3}, {T}, Sacrifice Dreamstone Hedron: Draw three cards.

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Lashwrithe

Living weapon (When this Equipment enters, create a 0/0 black Phyrexian Germ creature token, then attach this to it.)
Equipped creature gets +1/+1 for each Swamp you control.
Equip {B/P}{B/P} ({B/P} can be paid with either {B} or 2 life.)

Plague Engineer

Deathtouch
As Plague Engineer enters, choose a creature type.
Creatures of the chosen type your opponents control get -1/-1.

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Contagion Clasp

When Contagion Clasp enters, put a -1/-1 counter on target creature.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Puppet Strings

{2}, {T}: You may tap or untap target creature.

Phyrexian Processor

As Phyrexian Processor enters, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as Phyrexian Processor entered.

Hedron Archive

{T}: Add {C}{C}.
{2}, {T}, Sacrifice Hedron Archive: Draw two cards.

Soul of New Phyrexia

Trample
{5}: Permanents you control gain indestructible until end of turn.
{5}, Exile Soul of New Phyrexia from your graveyard: Permanents you control gain indestructible until end of turn.

Chancellor of the Dross

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent loses 3 life, then you gain life equal to the life lost this way.
Flying, lifelink

Psychogenic Probe

Whenever a spell or ability causes a player to shuffle their library, Psychogenic Probe deals 2 damage to that player.

Black Sun's Zenith

Put X -1/-1 counters on each creature. Shuffle Black Sun's Zenith into its owner's library.

Profane Memento

Whenever a creature card is put into an opponent's graveyard from anywhere, you gain 1 life.

Orbs of Warding

You have hexproof. (You can't be the target of spells or abilities your opponents control.)
If a creature would deal damage to you, prevent 1 of that damage.

Roving Keep

Defender
{7}: Roving Keep gets +2/+0 and gains trample until end of turn. It can attack this turn as though it didn't have defender.

Delif's Cube

{2}, {T}: This turn, when target creature you control attacks and isn't blocked, it assigns no combat damage this turn and you put a cube counter on Delif's Cube.
{2}, Remove a cube counter from Delif's Cube: Regenerate target creature.

Altar of Shadows

At the beginning of your first main phase, add {B} for each charge counter on Altar of Shadows.
{7}, {T}: Destroy target creature. Then put a charge counter on Altar of Shadows.

Phyrexian Slayer

Flying
Whenever Phyrexian Slayer becomes blocked by a white creature, destroy that creature. It can't be regenerated.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Ring of Gix

Echo {3} (At the beginning of your upkeep, if this came under your control since the beginning of your last upkeep, sacrifice it unless you pay its echo cost.)
{1}, {T}: Tap target artifact, creature, or land.

Bonehoard

Living weapon (When this Equipment enters, create a 0/0 black Phyrexian Germ creature token, then attach this to it.)
Equipped creature gets +X/+X, where X is the number of creature cards in all graveyards.
Equip {2}

Phyrexian Reaper

Whenever Phyrexian Reaper becomes blocked by a green creature, destroy that creature. It can't be regenerated.

Living Wall

Defender (This creature can't attack.)
{1}: Regenerate Living Wall.

Otarian Juggernaut

Otarian Juggernaut can't be blocked by Walls.
Threshold — As long as seven or more cards are in your graveyard, Otarian Juggernaut gets +3/+0 and attacks each combat if able.

Phyrexian Obliterator

Trample
Whenever a source deals damage to Phyrexian Obliterator, that source's controller sacrifices that many permanents.