Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Llanowar Wastes

{T}: Add {C}.
{T}: Add {B} or {G}. Llanowar Wastes deals 1 damage to you.

Moltensteel Dragon

({R/P} can be paid with either {R} or 2 life.)
Flying
{R/P}: Moltensteel Dragon gets +1/+0 until end of turn.

Congregate

Target player gains 2 life for each creature on the battlefield.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Sulfurous Springs

{T}: Add {C}.
{T}: Add {B} or {R}. Sulfurous Springs deals 1 damage to you.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Farseek

Search your library for a Plains, Island, Swamp, or Mountain card, put it onto the battlefield tapped, then shuffle.

Greed

Eternity Vessel

Eternity Vessel enters the battlefield with X charge counters on it, where X is your life total.
Landfall — Whenever a land enters the battlefield under your control, you may have your life total become the number of charge counters on Eternity Vessel.

Slaughter

Buyback—Pay 4 life. (You may pay 4 life in addition to any other costs as you cast this spell. If you do, put this card into your hand as it resolves.)
Destroy target nonblack creature. It can't be regenerated.

Deflecting Palm

The next time a source of your choice would deal damage to you this turn, prevent that damage. If damage is prevented this way, Deflecting Palm deals that much damage to that source's controller.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Sol Ring

Cultivate

Search your library for up to two basic land cards, reveal those cards, put one onto the battlefield tapped and the other into your hand, then shuffle.

Savage Lands

Savage Lands enters the battlefield tapped.
{T}: Add {B}, {R}, or {G}.

Jade Monolith

{1}: The next time a source of your choice would deal damage to target creature this turn, that source deals that damage to you instead.

Grand Coliseum

Grand Coliseum enters the battlefield tapped.
{T}: Add {C}.
{T}: Add one mana of any color. Grand Coliseum deals 1 damage to you.

Angel of Grace

Flash
Flying
When Angel of Grace enters the battlefield, until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.
{4}{W}{W}, Exile Angel of Grace from your graveyard: Your life total becomes 10.

Pariah

Enchant creature
All damage that would be dealt to you is dealt to enchanted creature instead.

Neheb, the Eternal

Afflict 3 (Whenever this creature becomes blocked, defending player loses 3 life.)
At the beginning of your postcombat main phase, add {R} for each 1 life your opponents have lost this turn.

Nomad Outpost

Nomad Outpost enters the battlefield tapped.
{T}: Add {R}, {W}, or {B}.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Solemnity

Players can't get counters.
Counters can't be put on artifacts, creatures, enchantments, or lands.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Worship

If you control a creature, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Curse of Vengeance

Enchant player
Whenever enchanted player casts a spell, put a spite counter on Curse of Vengeance.
When enchanted player loses the game, you gain X life and draw X cards, where X is the number of spite counters on Curse of Vengeance.

Selfless Squire

Flash
When Selfless Squire enters the battlefield, prevent all damage that would be dealt to you this turn.
Whenever damage that would be dealt to you is prevented, put that many +1/+1 counters on Selfless Squire.

Exquisite Archangel

Flying
If you would lose the game, instead exile Exquisite Archangel and your life total becomes equal to your starting life total.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Elderscale Wurm

Trample
When Elderscale Wurm enters the battlefield, if your life total is less than 7, your life total becomes 7.
As long as you have 7 or more life, damage that would reduce your life total to less than 7 reduces it to 7 instead.

Phyrexian Processor

As Phyrexian Processor enters the battlefield, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as Phyrexian Processor entered the battlefield.

Karplusan Forest

{T}: Add {C}.
{T}: Add {R} or {G}. Karplusan Forest deals 1 damage to you.

Joiner Adept

Lands you control have "{T}: Add one mana of any color."

Swamp

Salt Flats

Salt Flats enters the battlefield tapped.
{T}: Add {C}.
{T}: Add {W} or {B}. Salt Flats deals 1 damage to you.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Blossoming Bogbeast

Whenever Blossoming Bogbeast attacks, you gain 2 life. Then creatures you control gain trample and get +X/+X until end of turn, where X is the amount of life you gained this turn.

Saskia the Unyielding

Vigilance, haste
As Saskia the Unyielding enters the battlefield, choose a player.
Whenever a creature you control deals combat damage to a player, it deals that much damage to the chosen player.

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Mages' Contest

You and target spell's controller bid life. You start the bidding with a bid of 1. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid. If you win the bidding, counter that spell.

Dryad of the Ilysian Grove

You may play an additional land on each of your turns.
Lands you control are every basic land type in addition to their other types.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Pine Barrens

Pine Barrens enters the battlefield tapped.
{T}: Add {C}.
{T}: Add {B} or {G}. Pine Barrens deals 1 damage to you.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Resolute Archangel

Flying
When Resolute Archangel enters the battlefield, if your life total is less than your starting life total, it becomes equal to your starting life total.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Fortune Thief

Damage that would reduce your life total to less than 1 reduces it to 1 instead.
Morph {R}{R} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Mirari's Wake

Creatures you control get +1/+1.
Whenever you tap a land for mana, add one mana of any type that land produced.

Plains

Chromatic Lantern

Lands you control have "{T}: Add one mana of any color."
{T}: Add one mana of any color.

Murmuring Bosk

({T}: Add {G}.)
As Murmuring Bosk enters the battlefield, you may reveal a Treefolk card from your hand. If you don't, Murmuring Bosk enters the battlefield tapped.
{T}: Add {W} or {B}. Murmuring Bosk deals 1 damage to you.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters the battlefield, each player loses a third of their life, rounded up.

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Battlefield Forge

{T}: Add {C}.
{T}: Add {R} or {W}. Battlefield Forge deals 1 damage to you.

Treasonous Ogre

Dethrone (Whenever this creature attacks the player with the most life or tied for most life, put a +1/+1 counter on it.)
Pay 3 life: Add {R}.

Forest

Mountain

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Pariah's Shield

All damage that would be dealt to you is dealt to equipped creature instead.
Equip {3}

Scabland

Scabland enters the battlefield tapped.
{T}: Add {C}.
{T}: Add {R} or {W}. Scabland deals 1 damage to you.

Soulgorger Orgg

Trample
When Soulgorger Orgg enters the battlefield, you lose all but 1 life.
When Soulgorger Orgg leaves the battlefield, you gain life equal to the life you lost when it entered the battlefield.

Phyrexian Purge

This spell costs 3 life more to cast for each target.
Destroy any number of target creatures.

Children of Korlis

Sacrifice Children of Korlis: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

Evra, Halcyon Witness

Lifelink
{4}: Exchange your life total with Evra, Halcyon Witness's power.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Master of Cruelties

First strike, deathtouch
Master of Cruelties can only attack alone.
Whenever Master of Cruelties attacks a player and isn't blocked, that player's life total becomes 1. Master of Cruelties assigns no combat damage this combat.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Stuffy Doll

Indestructible
As Stuffy Doll enters the battlefield, choose a player.
Whenever Stuffy Doll is dealt damage, it deals that much damage to the chosen player.
{T}: Stuffy Doll deals 1 damage to itself.

Glacial Chasm

Cumulative upkeep—Pay 2 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
When Glacial Chasm enters the battlefield, sacrifice a land.
Creatures you control can't attack.
Prevent all damage that would be dealt to you.

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Plague of Vermin

Starting with you, each player may pay any amount of life. Repeat this process until no one pays life. Each player creates a 1/1 black Rat creature token for each 1 life they paid this way.

Tainted Sigil

{T}, Sacrifice Tainted Sigil: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Jungle Shrine

Jungle Shrine enters the battlefield tapped.
{T}: Add {R}, {G}, or {W}.

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Comeuppance

Prevent all damage that would be dealt to you and planeswalkers you control this turn by sources you don't control. If damage from a creature source is prevented this way, Comeuppance deals that much damage to that creature. If damage from a noncreature source is prevented this way, Comeuppance deals that much damage to the source's controller.

Birds of Paradise

Tree of Redemption

Defender
{T}: Exchange your life total with Tree of Redemption's toughness.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Sower of Discord

Flying
As Sower of Discord enters the battlefield, choose two players.
Whenever damage is dealt to one of the chosen players, the other chosen player also loses that much life.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Pain's Reward

Each player may bid life. You start the bidding with a bid of any number. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and draws four cards.