Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Vizkopa Confessor

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
When this creature enters, pay any amount of life. Target opponent reveals that many cards from their hand. You choose one of them and exile it.

Soul Echo

This enchantment enters with X echo counters on it.
You don't lose the game for having 0 or less life.
At the beginning of your upkeep, sacrifice this enchantment if there are no echo counters on it. Otherwise, target opponent may choose that for each 1 damage that would be dealt to you until your next upkeep, you remove an echo counter from this enchantment instead.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Nine Lives

Hexproof
If a source would deal damage to you, prevent that damage and put an incarnation counter on this enchantment.
When there are nine or more incarnation counters on this enchantment, exile it.
When this enchantment leaves the battlefield, you lose the game.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Second Sunrise

Each player returns to the battlefield all artifact, creature, enchantment, and land cards in their graveyard that were put there from the battlefield this turn.

Cradle of Vitality

Whenever you gain life, you may pay {1}{W}. If you do, put a +1/+1 counter on target creature for each 1 life you gained.

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Snuff Out

If you control a Swamp, you may pay 4 life rather than pay this spell's mana cost.
Destroy target nonblack creature. It can't be regenerated.

Swamp

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Nykthos Paragon

Whenever you gain life, you may put that many +1/+1 counters on each creature you control. Do this only once each turn.

Aether Snap

Remove all counters from all permanents and exile all tokens.

Temporal Extortion

When you cast this spell, any player may pay half their life, rounded up. If a player does, counter Temporal Extortion.
Take an extra turn after this one.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Evra, Halcyon Witness

Lifelink
{4}: Exchange your life total with Evra's power.

Transcendence

You don't lose the game for having 0 or less life.
When you have 20 or more life, you lose the game.
Whenever you lose life, you gain 2 life for each 1 life you lost. (Damage dealt to you causes you to lose life.)

Sol Ring

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Delaying Shield

If damage would be dealt to you, put that many delay counters on this enchantment instead.
At the beginning of your upkeep, remove all delay counters from this enchantment. For each delay counter removed this way, you lose 1 life unless you pay {1}{W}.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: This creature gets +1/+1 until end of turn.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice this artifact: Draw a card.

Lurking Evil

Pay half your life, rounded up: This enchantment becomes a 4/4 Phyrexian Horror creature with flying.

Hex Parasite

{X}{B/P}: Remove up to X counters from target permanent. For each counter removed this way, this creature gets +1/+0 until end of turn. ({B/P} can be paid with either {B} or 2 life.)

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Platinum Emperion

Your life total can't change. (You can't gain or lose life. You can't pay any amount of life except 0.)

Angelic Enforcer

Flying
You have hexproof.
This creature's power and toughness are each equal to your life total.
Whenever this creature attacks, double your life total.

Enduring Angel

Flying, double strike
You have hexproof.
If your life total would be reduced to 0 or less, instead transform this creature and your life total becomes 3. Then if this creature didn't transform this way, you lose the game.

Enduring Angel // Angelic Enforcer

Plague of Vermin

Starting with you, each player may pay any amount of life. Repeat this process until no one pays life. Each player creates a 1/1 black Rat creature token for each 1 life they paid this way.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Resolute Archangel

Flying
When this creature enters, if your life total is less than your starting life total, it becomes equal to your starting life total.

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Vampire Hexmage

First strike
Sacrifice this creature: Remove all counters from target permanent.

Solemnity

Players can't get counters.
Counters can't be put on artifacts, creatures, enchantments, or lands.

Sign in Blood

Target player draws two cards and loses 2 life.

Abyssal Persecutor

Flying, trample
You can't win the game and your opponents can't lose the game.

Hedron Archive

{T}: Add {C}{C}.
{2}, {T}, Sacrifice this artifact: Draw two cards.

Worship

If you control a creature, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Pain Seer

Inspired — Whenever this creature becomes untapped, reveal the top card of your library and put that card into your hand. You lose life equal to that card's mana value.

Orzhov Cluestone

{T}: Add {W} or {B}.
{W}{B}, {T}, Sacrifice this artifact: Draw a card.

Treasury Thrull

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever this creature attacks, you may return target artifact, creature, or enchantment card from your graveyard to your hand.

Blessed Wind

Spirit Loop

Enchant creature you control
Whenever enchanted creature deals damage, you gain that much life.
When this Aura is put into a graveyard from the battlefield, return it to its owner's hand.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Mortify

Intervention Pact

The next time a source of your choice would deal damage to you this turn, prevent that damage. You gain life equal to the damage prevented this way.
At the beginning of your next upkeep, pay {1}{W}{W}. If you don't, you lose the game.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Cloudsteel Kirin

Flying
Equipped creature has flying and "You can't lose the game and your opponents can't win the game."
Reconfigure {5} ({5}: Attach to target creature you control; or unattach from a creature. Reconfigure only as a sorcery. While attached, this isn't a creature.)

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Thran Dynamo

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with this creature's toughness.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Debtors' Knell

({W/B} can be paid with either {W} or {B}.)
At the beginning of your upkeep, put target creature card from a graveyard onto the battlefield under your control.

Sanguine Sacrament

You gain twice X life. Put Sanguine Sacrament on the bottom of its owner's library.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Force Bubble

If damage would be dealt to you, put that many depletion counters on this enchantment instead.
When there are four or more depletion counters on this enchantment, sacrifice it.
At the beginning of each end step, remove all depletion counters from this enchantment.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

The Book of Exalted Deeds

At the beginning of your end step, if you gained 3 or more life this turn, create a 3/3 white Angel creature token with flying.
{W}{W}{W}, {T}, Exile The Book of Exalted Deeds: Put an enlightened counter on target Angel. It gains "You can't lose the game and your opponents can't win the game." Activate only as a sorcery.

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Whip of Erebos

Creatures you control have lifelink.
{2}{B}{B}, {T}: Return target creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step. If it would leave the battlefield, exile it instead of putting it anywhere else. Activate only as a sorcery.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Wall of Shards

Defender, flying
Cumulative upkeep—An opponent gains 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Cemetery Desecrator

Menace
When this creature enters or dies, exile another card from a graveyard. When you do, choose one —
• Remove X counters from target permanent, where X is the mana value of the exiled card.
• Target creature an opponent controls gets -X/-X until end of turn, where X is the mana value of the exiled card.

Pact Weapon

As long as this Equipment is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Dark Tutelage

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Gideon of the Trials

+1: Until your next turn, prevent all damage target permanent would deal.
0: Until end of turn, Gideon of the Trials becomes a 4/4 Human Soldier creature with indestructible that's still a planeswalker. Prevent all damage that would be dealt to him this turn.
0: You get an emblem with "As long as you control a Gideon planeswalker, you can't lose the game and your opponents can't win the game."

Dreamstone Hedron

{T}: Add {C}{C}{C}.
{3}, {T}, Sacrifice this artifact: Draw three cards.

Magus of the Mirror

{T}, Sacrifice this creature: Exchange life totals with target opponent. Activate only during your upkeep.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Dawn of Hope

Whenever you gain life, you may pay {2}. If you do, draw a card.
{3}{W}: Create a 1/1 white Soldier creature token with lifelink.

Hatred

As an additional cost to cast this spell, pay X life.
Target creature gets +X/+0 until end of turn.

Arbiter of Knollridge

Vigilance
When this creature enters, each player's life total becomes the highest life total among all players.

Selenia, Dark Angel

Flying
Pay 2 life: Return Selenia to its owner's hand.

Angel of Grace

Flash
Flying
When this creature enters, until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.
{4}{W}{W}, Exile this card from your graveyard: Your life total becomes 10.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Doom Whisperer

Flying, trample
Pay 2 life: Surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Phyrexian Reclamation

{1}{B}, Pay 2 life: Return target creature card from your graveyard to your hand.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Providence

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, your life total becomes 26.
Your life total becomes 26.

Rhox Faithmender

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
If you would gain life, you gain twice that much life instead.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Price of Betrayal

Remove up to five counters from target artifact, creature, planeswalker, or opponent.

Boon Reflection

If you would gain life, you gain twice that much life instead.

Pain's Reward

Each player may bid life. You start the bidding with a bid of any number. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and draws four cards.

Celestial Mantle

Enchant creature
Enchanted creature gets +3/+3.
Whenever enchanted creature deals combat damage to a player, double its controller's life total.

Succumb to Temptation

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Slaughter Pact

Destroy target nonblack creature.
At the beginning of your next upkeep, pay {2}{B}. If you don't, you lose the game.

Tainted Sigil

{T}, Sacrifice this artifact: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Plains

Font of Agonies

Whenever you pay life, put that many blood counters on this enchantment.
{1}{B}, Remove four blood counters from this enchantment: Destroy target creature.