Fathom Fleet Boarder

When Fathom Fleet Boarder enters, you lose 2 life unless you control another Pirate.

Sorrow's Path

{T}: Choose two target blocking creatures controlled by the same opponent. If each of those creatures could block all creatures that the other is blocking, remove both of them from combat. Each one then blocks all creatures the other was blocking.
Whenever Sorrow's Path becomes tapped, it deals 2 damage to you and each creature you control.

Glorifier of Dusk

Pay 2 life: Glorifier of Dusk gains flying until end of turn.
Pay 2 life: Glorifier of Dusk gains vigilance until end of turn.

Carrion Howler

Pay 1 life: Carrion Howler gets +2/-1 until end of turn.

Raving Oni-Slave

When Raving Oni-Slave enters or leaves the battlefield, you lose 3 life if you don't control a Demon.

Ancient Tomb

{T}: Add {C}{C}. Ancient Tomb deals 2 damage to you.

Necrogen Scudder

Flying
When Necrogen Scudder enters, you lose 3 life.

Arco-Flagellant

Squad {2} (As an additional cost to cast this spell, you may pay {2} any number of times. When this creature enters, create that many tokens that are copies of it.)
Arco-Flagellant can't block.
Endurant — Pay 3 life: Arco-Flagellant gains indestructible until end of turn.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Vault of Champions

Vault of Champions enters tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Intervention Pact

The next time a source of your choice would deal damage to you this turn, prevent that damage. You gain life equal to the damage prevented this way.
At the beginning of your next upkeep, pay {1}{W}{W}. If you don't, you lose the game.

Ulcerate

Target creature gets -3/-3 until end of turn. You lose 3 life.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Bitter Revelation

Look at the top four cards of your library. Put two of them into your hand and the rest into your graveyard. You lose 2 life.

Transcendence

You don't lose the game for having 0 or less life.
When you have 20 or more life, you lose the game.
Whenever you lose life, you gain 2 life for each 1 life you lost. (Damage dealt to you causes you to lose life.)

Spoils of the Vault

Choose a card name. Reveal cards from the top of your library until you reveal a card with that name, then put that card into your hand. Exile all other cards revealed this way, and you lose 1 life for each of the exiled cards.

Orzhov Signet

Soul Channeling

Enchant creature
Pay 2 life: Regenerate enchanted creature.

Phyrexian Processor

As Phyrexian Processor enters, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as Phyrexian Processor entered.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Night's Whisper

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Slaughter Pact

Destroy target nonblack creature.
At the beginning of your next upkeep, pay {2}{B}. If you don't, you lose the game.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Toxic Abomination

When Toxic Abomination enters, you lose 2 life.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Adanto Vanguard

As long as Adanto Vanguard is attacking, it gets +2/+0.
Pay 4 life: Adanto Vanguard gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Tethered Skirge

Flying
Whenever Tethered Skirge becomes the target of a spell or ability, you lose 1 life.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Mana Confluence

{T}, Pay 1 life: Add one mana of any color.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Crovax, Ascendant Hero

Other white creatures get +1/+1.
Nonwhite creatures get -1/-1.
Pay 2 life: Return Crovax, Ascendant Hero to its owner's hand.

Shattered Sanctum

Shattered Sanctum enters tapped unless you control two or more other lands.
{T}: Add {W} or {B}.

Foul Imp

Flying
When Foul Imp enters, you lose 2 life.

Phyrexian Rager

When Phyrexian Rager enters, you draw a card and you lose 1 life.

Boon of Erebos

Target creature gets +2/+0 until end of turn. Regenerate it. You lose 2 life.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Martyrs' Tomb

Pay 2 life: Prevent the next 1 damage that would be dealt to target creature this turn.

Dark Ritual

Ebon Drake

Flying
Whenever a player casts a spell, you lose 1 life.

Souldrinker

Pay 3 life: Put a +1/+1 counter on Souldrinker.

Fetid Heath

{T}: Add {C}.
{W/B}, {T}: Add {W}{W}, {W}{B}, or {B}{B}.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Ethereal Champion

Pay 1 life: Prevent the next 1 damage that would be dealt to Ethereal Champion this turn.

Minion of the Wastes

Trample
As Minion of the Wastes enters, pay any amount of life.
Minion of the Wastes's power and toughness are each equal to the life paid as it entered.

Ancient Craving

You draw three cards and you lose 3 life.

Shattered Crypt

Return X target creature cards from your graveyard to your hand. You lose X life.

Tomb of Urami

{T}: Add {B}. Tomb of Urami deals 1 damage to you if you don't control an Ogre.
{2}{B}{B}, {T}, Sacrifice all lands you control: Create Urami, a legendary 5/5 black Demon Spirit creature token with flying.

Tarnished Citadel

{T}: Add {C}.
{T}: Add one mana of any color. Tarnished Citadel deals 3 damage to you.

Reign of Terror

Destroy all green creatures or all white creatures. They can't be regenerated. You lose 2 life for each creature that died this way.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters, you may pay 2 life. If you don't, it enters tapped.

Ambition's Cost

Skeletal Scrying

As an additional cost to cast this spell, exile X cards from your graveyard.
You draw X cards and you lose X life.

Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Vizkopa Confessor

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
When Vizkopa Confessor enters, pay any amount of life. Target opponent reveals that many cards from their hand. You choose one of them and exile it.

Plains

Blood Price

Look at the top four cards of your library. Put two of them into your hand and the rest on the bottom of your library in any order. You lose 2 life.

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice Silent Clearing: Draw a card.

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Mischievous Poltergeist

Flying
Pay 1 life: Regenerate Mischievous Poltergeist.

Demonic Consultation

Choose a card name. Exile the top six cards of your library, then reveal cards from the top of your library until you reveal a card with the chosen name. Put that card into your hand and exile all other cards revealed this way.

Reckless Spite

Destroy two target nonblack creatures. You lose 5 life.

City of Brass

Whenever City of Brass becomes tapped, it deals 1 damage to you.
{T}: Add one mana of any color.

Marsh Flats

{T}, Pay 1 life, Sacrifice Marsh Flats: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Plague of Vermin

Starting with you, each player may pay any amount of life. Repeat this process until no one pays life. Each player creates a 1/1 black Rat creature token for each 1 life they paid this way.

Selenia, Dark Angel

Flying
Pay 2 life: Return Selenia, Dark Angel to its owner's hand.

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Shadowcloak Vampire

Pay 2 life: Shadowcloak Vampire gains flying until end of turn. (It can't be blocked except by creatures with flying or reach.)

Grand Coliseum

Grand Coliseum enters tapped.
{T}: Add {C}.
{T}: Add one mana of any color. Grand Coliseum deals 1 damage to you.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Serum Powder

{T}: Add {C}.
Any time you could mulligan and Serum Powder is in your hand, you may exile all the cards from your hand, then draw that many cards. (You can do this in addition to taking mulligans.)

Doom Whisperer

Flying, trample
Pay 2 life: Surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Swamp

Infernal Grasp

Destroy target creature. You lose 2 life.

Serpent Warrior

When Serpent Warrior enters, you lose 3 life.

Cabal Pit

{T}: Add {B}. Cabal Pit deals 1 damage to you.
Threshold — {B}, {T}, Sacrifice Cabal Pit: Target creature gets -2/-2 until end of turn. Activate only if seven or more cards are in your graveyard.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Deepwood Ghoul

Salt Flats

Salt Flats enters tapped.
{T}: Add {C}.
{T}: Add {W} or {B}. Salt Flats deals 1 damage to you.