Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Blade Juggler

Spectacle {2}{B} (You may cast this spell for its spectacle cost rather than its mana cost if an opponent lost life this turn.)
When Blade Juggler enters, it deals 1 damage to you and you draw a card.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Viper's Kiss

Enchant creature
Enchanted creature gets -1/-1, and its activated abilities can't be activated.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Curse of Fool's Wisdom

Enchant player
Whenever enchanted player draws a card, they lose 2 life and you gain 2 life.
Madness {3}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Myojin of Night's Reach

Myojin of Night's Reach enters with a divinity counter on it if you cast it from your hand.
Myojin of Night's Reach has indestructible as long as it has a divinity counter on it.
Remove a divinity counter from Myojin of Night's Reach: Each opponent discards their hand.

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Bloodtithe Collector

Flying
When this creature enters, if an opponent lost life this turn, each opponent discards a card.

Banshee of the Dread Choir

Myriad (Whenever this creature attacks, for each opponent other than defending player, you may create a token copy that's tapped and attacking that player or a planeswalker they control. Exile the tokens at end of combat.)
Whenever Banshee of the Dread Choir deals combat damage to a player, that player discards a card.

Westgate Regent

Flying
Ward—Discard a card. (Whenever this creature becomes the target of a spell or ability an opponent controls, counter it unless that player discards a card.)
Whenever Westgate Regent deals combat damage to a player, put that many +1/+1 counters on it.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Capital Punishment

Council's dilemma — Starting with you, each player votes for death or taxes. Each opponent sacrifices a creature of their choice for each death vote and discards a card for each taxes vote.

Courier Bat

Flying
When Courier Bat enters, if you gained life this turn, return up to one target creature card from your graveyard to your hand.

Audacious Thief

Whenever Audacious Thief attacks, you draw a card and you lose 1 life.

Eternal Thirst

Enchant creature
Enchanted creature has lifelink and "Whenever a creature an opponent controls dies, put a +1/+1 counter on this creature." (Damage dealt by a creature with lifelink also causes its controller to gain that much life.)

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Kamber, the Plunderer

Partner with Laurine, the Diversion (When this creature enters, target player may put Laurine into their hand from their library, then shuffle.)
Lifelink
Whenever a creature an opponent controls dies, you gain 1 life and create a Blood token. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this artifact: Draw a card.")

Venser's Journal

You have no maximum hand size.
At the beginning of your upkeep, you gain 1 life for each card in your hand.

Consuming Vapors

Target player sacrifices a creature of their choice. You gain life equal to that creature's toughness.
Rebound (If you cast this spell from your hand, exile it as it resolves. At the beginning of your next upkeep, you may cast this card from exile without paying its mana cost.)

Aspect of Lamprey

Enchant creature you control
When Aspect of Lamprey enters, target opponent discards two cards.
Enchanted creature has lifelink.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Blood Pact

Target player draws two cards and loses 2 life.

Bloodbond Vampire

Whenever you gain life, put a +1/+1 counter on Bloodbond Vampire.

Demogorgon's Clutches

Target opponent discards two cards, mills two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Fell Specter

Flying
When Fell Specter enters, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Crypt Incursion

Exile all creature cards from target player's graveyard. You gain 3 life for each card exiled this way.

Coercion

Target opponent reveals their hand. You choose a card from it. That player discards that card.

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Bloodhusk Ritualist

Multikicker {B} (You may pay an additional {B} any number of times as you cast this spell.)
When Bloodhusk Ritualist enters, target opponent discards a card for each time it was kicked.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Ancient Craving

You draw three cards and you lose 3 life.

The Haunt of Hightower

Flying, lifelink
Whenever The Haunt of Hightower attacks, defending player discards a card.
Whenever a card is put into an opponent's graveyard from anywhere, put a +1/+1 counter on The Haunt of Hightower.

Archon of Cruelty

Flying
Whenever Archon of Cruelty enters or attacks, target opponent sacrifices a creature or planeswalker of their choice, discards a card, and loses 3 life. You draw a card and gain 3 life.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Callous Bloodmage

When Callous Bloodmage enters, choose one —
• Create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."
• You draw a card and you lose 1 life.
• Exile target player's graveyard.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Author of Shadows

When Author of Shadows enters, exile all opponents' graveyards. Choose a nonland card exiled this way. You may cast that card for as long as it remains exiled, and you may spend mana as though it were mana of any color to cast that spell.

Feast of Sanity

Whenever you discard a card, Feast of Sanity deals 1 damage to any target and you gain 1 life.

Tinybones, Trinket Thief

At the beginning of each end step, if an opponent discarded a card this turn, you draw a card and you lose 1 life.
{4}{B}{B}: Each opponent with no cards in hand loses 10 life.

Scythe Specter

Flying
Whenever Scythe Specter deals combat damage to a player, each opponent discards a card. Each player who discarded a card with the highest mana value among cards discarded this way loses life equal to that mana value.

Alms of the Vein

Target opponent loses 3 life and you gain 3 life.
Madness {B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Absorb Vis

Target player loses 4 life and you gain 4 life.
Basic landcycling {1}{B} ({1}{B}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Netherborn Phalanx

When Netherborn Phalanx enters, each opponent loses 1 life for each creature they control.
Transmute {1}{B}{B} ({1}{B}{B}, Discard this card: Search your library for a card with the same mana value as this card, reveal it, put it into your hand, then then shuffle. Transmute only as a sorcery.)

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Swamp

Davriel's Shadowfugue

Target player discards two cards and loses 2 life.

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Elixir of Immortality

{2}, {T}: You gain 5 life. Shuffle Elixir of Immortality and your graveyard into their owner's library.

Stabwhisker the Odious

At the beginning of each opponent's upkeep, that player loses 1 life for each card fewer than three in their hand.

Nezumi Shortfang

{1}{B}, {T}: Target opponent discards a card. Then if that player has no cards in hand, flip Nezumi Shortfang.

Nezumi Shortfang // Stabwhisker the Odious

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters, if it was kicked, target opponent discards two cards at random.

Indulgent Tormentor

Flying
At the beginning of your upkeep, draw a card unless target opponent sacrifices a creature of their choice or pays 3 life.

Dusk Mangler

As an additional cost to cast this spell, sacrifice a creature, discard a card, or pay 4 life.
When Dusk Mangler enters, each opponent sacrifices a creature of their choice, discards a card, and loses 4 life.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Whip of Erebos

Creatures you control have lifelink.
{2}{B}{B}, {T}: Return target creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step. If it would leave the battlefield, exile it instead of putting it anywhere else. Activate only as a sorcery.

Ambition's Cost

Mind Drain

Target opponent discards two cards, mills a card, and loses 1 life. You gain 1 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Dark Inquiry

Target opponent reveals their hand. You choose a nonland card from it. That player discards that card.