Cut Your Losses

Casualty 2 (As you cast this spell, you may sacrifice a creature with power 2 or greater. When you do, copy this spell and you may choose a new target for the copy.)
Target player mills half their library, rounded down.

Ashiok, Nightmare Muse

+1: Create a 2/3 blue and black Nightmare creature token with "Whenever this creature attacks or blocks, each opponent exiles the top two cards of their library."
−3: Return target nonland permanent to its owner's hand, then that player exiles a card from their hand.
−7: You may cast up to three spells from among face-up cards your opponents own from exile without paying their mana costs.

Leyline of the Void

If Leyline of the Void is in your opening hand, you may begin the game with it on the battlefield.
If a card would be put into an opponent's graveyard from anywhere, exile it instead.

Dauthi Voidwalker

Shadow (This creature can block or be blocked by only creatures with shadow.)
If a card would be put into an opponent's graveyard from anywhere, instead exile it with a void counter on it.
{T}, Sacrifice Dauthi Voidwalker: Choose an exiled card an opponent owns with a void counter on it. You may play it this turn without paying its mana cost.

Umbris, Fear Manifest

Umbris, Fear Manifest gets +1/+1 for each card your opponents own in exile.
Whenever Umbris or another Nightmare or Horror you control enters, target opponent exiles cards from the top of their library until they exile a land card.

Tasha's Hideous Laughter

Each opponent exiles cards from the top of their library until that player has exiled cards with total mana value 20 or more.

Ashiok, Dream Render

Spells and abilities your opponents control can't cause their controller to search their library.
−1: Target player mills four cards. Then exile each opponent's graveyard.

Maddening Cacophony

Kicker {3}{U}
Each opponent mills eight cards. If this spell was kicked, instead each opponent mills half their library, rounded up.