Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Isochron Scepter

Imprint — When Isochron Scepter enters, you may exile an instant card with mana value 2 or less from your hand.
{2}, {T}: You may copy the exiled card. If you do, you may cast the copy without paying its mana cost.

Merchant Scroll

Search your library for a blue instant card, reveal that card, put it into your hand, then shuffle.

Baleful Strix

Flying, deathtouch
When Baleful Strix enters, draw a card.

Drowned Catacomb

Drowned Catacomb enters tapped unless you control an Island or a Swamp.
{T}: Add {U} or {B}.

Virtus's Maneuver

For each player, choose friend or foe. Each friend returns a creature card from their graveyard to their hand. Each foe sacrifices a creature of their choice.

Rapid Hybridization

Destroy target creature. It can't be regenerated. That creature's controller creates a 3/3 green Frog Lizard creature token.

Mystical Tutor

Search your library for an instant or sorcery card, reveal it, then shuffle and put that card on top.

Jwar Isle Refuge

Jwar Isle Refuge enters tapped.
When Jwar Isle Refuge enters, you gain 1 life.
{T}: Add {U} or {B}.

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Liliana's Triumph

Each opponent sacrifices a creature of their choice. If you control a Liliana planeswalker, each opponent also discards a card.

Geth's Verdict

Target player sacrifices a creature of their choice and loses 1 life.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Mire in Misery

Each opponent sacrifices a creature or enchantment of their choice.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Spawning Pit

Sacrifice a creature: Put a charge counter on Spawning Pit.
{1}, Remove two charge counters from Spawning Pit: Create a 2/2 colorless Spawn artifact creature token.

Deekah, Fractal Theorist

Magecraft — Whenever you cast or copy an instant or sorcery spell, create a 0/0 green and blue Fractal creature token. Put X +1/+1 counters on it, where X is that spell's mana value.
{3}{U}: Target creature token can't be blocked this turn.

Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Dralnu, Lich Lord

If damage would be dealt to Dralnu, Lich Lord, sacrifice that many permanents instead.
{T}: Target instant or sorcery card in your graveyard gains flashback until end of turn. The flashback cost is equal to its mana cost. (You may cast that card from your graveyard for its flashback cost. Then exile it.)

Professor Onyx

Magecraft — Whenever you cast or copy an instant or sorcery spell, each opponent loses 2 life and you gain 2 life.
+1: You lose 1 life. Look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
−3: Each opponent sacrifices a creature with the greatest power among creatures that player controls.
−8: Each opponent may discard a card. If they don't, they lose 3 life. Repeat this process six more times.

Secrets of the Golden City

Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
Draw two cards. If you have the city's blessing, draw three cards instead.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Lier, Disciple of the Drowned

Spells can't be countered.
Each instant and sorcery card in your graveyard has flashback. The flashback cost is equal to that card's mana cost.

Sea Gate, Reborn

As Sea Gate, Reborn enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {U}.

Sea Gate Restoration

Draw cards equal to the number of cards in your hand plus one. You have no maximum hand size for the rest of the game.

Sea Gate Restoration // Sea Gate, Reborn

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

The Meathook Massacre

When The Meathook Massacre enters, each creature gets -X/-X until end of turn.
Whenever a creature you control dies, each opponent loses 1 life.
Whenever a creature an opponent controls dies, you gain 1 life.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Island

Tendrils of Agony

Target player loses 2 life and you gain 2 life.
Storm (When you cast this spell, copy it for each spell cast before it this turn. You may choose new targets for the copies.)

Tasha, the Witch Queen

Whenever you cast a spell you don't own, create a 3/3 black Demon creature token.
+1: Draw a card. For each opponent, exile up to one target instant or sorcery card from that player's graveyard and put a page counter on it.
−3: You may cast a spell from among cards in exile with page counters on them without paying its mana cost.
Tasha, the Witch Queen can be your commander.

Jace's Sanctum

Instant and sorcery spells you cast cost {1} less to cast.
Whenever you cast an instant or sorcery spell, scry 1.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Mana Drain

Counter target spell. At the beginning of your next main phase, add an amount of {C} equal to that spell's mana value.

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Dimir Guildgate

This land enters tapped.
{T}: Add {U} or {B}.

Pongify

Destroy target creature. It can't be regenerated. Its controller creates a 3/3 green Ape creature token.

Woe Strider

When Woe Strider enters, create a 0/1 white Goat creature token.
Sacrifice another creature: Scry 1.
Escape—{3}{B}{B}, Exile four other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)
Woe Strider escapes with two +1/+1 counters on it.

Wizard Class

(Gain the next level as a sorcery to add its ability.)
You have no maximum hand size.
{2}{U}: Level 2
When this Class becomes level 2, draw two cards.
{4}{U}: Level 3
Whenever you draw a card, put a +1/+1 counter on target creature you control.

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Swamp

Theoretical Duplication

Whenever a nontoken creature an opponent controls enters this turn, create a token that's a copy of that creature.

Careful Study

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Dramatic Reversal

Untap all nonland permanents you control.

Tyrant's Choice

Will of the council — Starting with you, each player votes for death or torture. If death gets more votes, each opponent sacrifices a creature of their choice. If torture gets more votes or the vote is tied, each opponent loses 4 life.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Murmuring Mystic

Whenever you cast an instant or sorcery spell, create a 1/1 blue Bird Illusion creature token with flying.

Spelltwine

Exile target instant or sorcery card from your graveyard and target instant or sorcery card from an opponent's graveyard. Copy those cards. Cast the copies if able without paying their mana costs. Exile Spelltwine.

Deep Analysis

Target player draws two cards.
Flashback—{1}{U}, Pay 3 life. (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Dread Return

Return target creature card from your graveyard to the battlefield.
Flashback—Sacrifice three creatures. (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Plague of Vermin

Starting with you, each player may pay any amount of life. Repeat this process until no one pays life. Each player creates a 1/1 black Rat creature token for each 1 life they paid this way.

Gitaxian Probe

({U/P} can be paid with either {U} or 2 life.)
Look at target player's hand.
Draw a card.

Plumb the Forbidden

As an additional cost to cast this spell, you may sacrifice one or more creatures. When you do, copy this spell for each creature sacrificed this way.
You draw a card and you lose 1 life.

Inspiring Refrain

Draw two cards. Exile Inspiring Refrain with three time counters on it.
Suspend 3—{2}{U} (Rather than cast this card from your hand, you may pay {2}{U} and exile it with three time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)

Rona, Sheoldred's Faithful

Whenever you cast an instant or sorcery spell, each opponent loses 1 life.
You may cast Rona, Sheoldred's Faithful from your graveyard by discarding two cards in addition to paying its other costs.

Chemister's Insight

Draw two cards.
Jump-start (You may cast this card from your graveyard by discarding a card in addition to paying its other costs. Then exile this card.)

Thieving Skydiver

Kicker {X}. X can't be 0. (You may pay an additional {X} as you cast this spell.)
Flying
When Thieving Skydiver enters, if it was kicked, gain control of target artifact with mana value X or less. If that artifact is an Equipment, attach it to Thieving Skydiver.

Return to Action

Until end of turn, target creature gets +1/+0 and gains lifelink and "When this creature dies, return it to the battlefield tapped under its owner's control."

Thopter Spy Network

At the beginning of your upkeep, if you control an artifact, create a 1/1 colorless Thopter artifact creature token with flying.
Whenever one or more artifact creatures you control deal combat damage to a player, draw a card.

Sign in Blood

Target player draws two cards and loses 2 life.

Village Rites

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

Swarm Intelligence

Whenever you cast an instant or sorcery spell, you may copy that spell. You may choose new targets for the copy.

Murkwater Pathway

Clearwater Pathway

Clearwater Pathway // Murkwater Pathway

Battle at the Bridge

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
Target creature gets -X/-X until end of turn. You gain X life.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Diluvian Primordial

Flying
When Diluvian Primordial enters, for each opponent, you may cast up to one target instant or sorcery card from that player's graveyard without paying its mana cost. If a spell cast this way would be put into a graveyard, exile it instead.

Demonic Tutor

Dismal Backwater

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {U} or {B}.

Talent of the Telepath

Target opponent reveals the top seven cards of their library. You may cast an instant or sorcery spell from among them without paying its mana cost. Then that player puts the rest into their graveyard.
Spell mastery — If there are two or more instant and/or sorcery cards in your graveyard, you may cast up to two instant and/or sorcery spells from among the revealed cards instead of one.

Exotic Orchard

Talrand, Sky Summoner

Whenever you cast an instant or sorcery spell, create a 2/2 blue Drake creature token with flying.

Dimir Signet

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Scry 1. (Look at the top card of your library. You may put that card on the bottom.)
Draw a card.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

The Scarab God

At the beginning of your upkeep, each opponent loses X life and you scry X, where X is the number of Zombies you control.
{2}{U}{B}: Exile target creature card from a graveyard. Create a token that's a copy of it, except it's a 4/4 black Zombie.
When The Scarab God dies, return it to its owner's hand at the beginning of the next end step.

Dredge the Mire

Each opponent chooses a creature card in their graveyard. Put those cards onto the battlefield under your control.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Ashiok, Nightmare Muse

+1: Create a 2/3 blue and black Nightmare creature token with "Whenever this creature attacks or blocks, each opponent exiles the top two cards of their library."
−3: Return target nonland permanent to its owner's hand, then that player exiles a card from their hand.
−7: You may cast up to three spells from among face-up cards your opponents own from exile without paying their mana costs.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Explore the Vastlands

Each player looks at the top five cards of their library and may reveal a land card and/or an instant or sorcery card from among them. Each player puts the cards they revealed this way into their hand and the rest on the bottom of their library in a random order. Each player gains 3 life.

Wandering Archaic

Whenever an opponent casts an instant or sorcery spell, they may pay {2}. If they don't, you may copy that spell. You may choose new targets for the copy.

Wandering Archaic // Explore the Vastlands

Dark Ritual

Darkwater Catacombs

Memory Lapse

Counter target spell. If that spell is countered this way, put it on top of its owner's library instead of into that player's graveyard.

Frantic Search

Draw two cards, then discard two cards. Untap up to three lands.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Consider

Surveil 1. (Look at the top card of your library. You may put it into your graveyard.)
Draw a card.

Radical Idea

Draw a card.
Jump-start (You may cast this card from your graveyard by discarding a card in addition to paying its other costs. Then exile this card.)

Archmage Emeritus

Magecraft — Whenever you cast or copy an instant or sorcery spell, draw a card.

Watery Grave

({T}: Add {U} or {B}.)
As Watery Grave enters, you may pay 2 life. If you don't, it enters tapped.

Solemn Simulacrum

When this creature enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When this creature dies, you may draw a card.

Reliquary Tower

Death Tyrant

Menace
Negative Energy Cone — Whenever an attacking creature you control or a blocking creature an opponent controls dies, create a 2/2 black Zombie creature token.
{5}{B}: Return Death Tyrant from your graveyard to the battlefield tapped.

Innocent Blood

Each player sacrifices a creature of their choice.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Make an Example

Each opponent separates the creatures they control into two piles. For each opponent, you choose one of their piles. Each opponent sacrifices the creatures in their chosen pile. (Piles can be empty.)

Syphon Soul

Syphon Soul deals 2 damage to each other player. You gain life equal to the damage dealt this way.