Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Erebos, Bleak-Hearted

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature.
Whenever another creature you control dies, you may pay 2 life. If you do, draw a card.
{1}{B}, Sacrifice another creature: Target creature gets -2/-1 until end of turn.

Pact of the Serpent

Choose a creature type. Target player draws X cards and loses X life, where X is the number of creatures they control of the chosen type.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Sickening Dreams

As an additional cost to cast this spell, discard X cards.
Sickening Dreams deals X damage to each creature and each player.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Skirge Familiar

Bloodbond Vampire

Whenever you gain life, put a +1/+1 counter on Bloodbond Vampire.

Dark Ritual

Veinwitch Coven

Menace
Whenever you gain life, you may pay {B}. If you do, return target creature card from your graveyard to your hand.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Feast of Sanity

Whenever you discard a card, Feast of Sanity deals 1 damage to any target and you gain 1 life.

Sign in Blood

Target player draws two cards and loses 2 life.

Wall of Limbs

Defender (This creature can't attack.)
Whenever you gain life, put a +1/+1 counter on Wall of Limbs.
{5}{B}{B}, Sacrifice Wall of Limbs: Target player loses X life, where X is Wall of Limbs's power.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.