Agent of the Iron Throne

Commander creatures you own have "Whenever an artifact or creature you control is put into a graveyard from the battlefield, each opponent loses 1 life."

Gate to the Afterlife

Whenever a nontoken creature you control dies, you gain 1 life. Then you may draw a card. If you do, discard a card.
{2}, {T}, Sacrifice Gate to the Afterlife: Search your graveyard, hand, and/or library for a card named God-Pharaoh's Gift and put it onto the battlefield. If you search your library this way, shuffle. Activate only if there are six or more creature cards in your graveyard.

Sydri, Galvanic Genius

{U}: Target noncreature artifact becomes an artifact creature with power and toughness each equal to its mana value until end of turn.
{W}{B}: Target artifact creature gains deathtouch and lifelink until end of turn.

Oswald Fiddlebender

Magical Tinkering — {W}, {T}, Sacrifice an artifact: Search your library for an artifact card with mana value equal to 1 plus the sacrificed artifact's mana value, put it onto the battlefield, then shuffle. Activate only as a sorcery.

Eye of Vecna

When Eye of Vecna enters the battlefield, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Trinket Mage

When Trinket Mage enters the battlefield, you may search your library for an artifact card with mana value 1 or less, reveal that card, put it into your hand, then shuffle.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

The Book of Vile Darkness

At the beginning of your end step, if you lost 2 or more life this turn, create a 2/2 black Zombie creature token.
{T}, Exile The Book of Vile Darkness and artifacts you control named Eye of Vecna and Hand of Vecna: Create Vecna, a legendary 8/8 black Zombie God creature token with indestructible and all triggered abilities of the exiled cards.

Lich Lord of Unx

{U}{B}, {T}: Create a 1/1 blue and black Zombie Wizard creature token.
{U}{U}{B}{B}: Target player loses X life and mills X cards, where X is the number of Zombies you control.

Scrapyard Recombiner

Modular 2 (This creature enters the battlefield with two +1/+1 counters on it. When it dies, you may put its +1/+1 counters on target artifact creature.)
{T}, Sacrifice an artifact: Search your library for a Construct card, reveal it, put it into your hand, then shuffle.

Fabricate

Search your library for an artifact card, reveal it, put it into your hand, then shuffle.

Renowned Weaponsmith

{T}: Add {C}{C}. Spend this mana only to cast artifact spells or activate abilities of artifacts.
{U}, {T}: Search your library for a card named Heart-Piercer Bow or Vial of Dragonfire, reveal it, put it into your hand, then shuffle.

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Moonsilver Key

{1}, {T}, Sacrifice Moonsilver Key: Search your library for an artifact card with a mana ability or a basic land card, reveal it, put it into your hand, then shuffle.

Kuldotha Forgemaster

{T}, Sacrifice three artifacts: Search your library for an artifact card, put it onto the battlefield, then shuffle.

Inventors' Fair

At the beginning of your upkeep, if you control three or more artifacts, you gain 1 life.
{T}: Add {C}.
{4}, {T}, Sacrifice Inventors' Fair: Search your library for an artifact card, reveal it, put it into your hand, then shuffle. Activate only if you control three or more artifacts.

Tomebound Lich

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Whenever Tomebound Lich enters the battlefield or deals combat damage to a player, draw a card, then discard a card.

Vexing Puzzlebox

Whenever you roll one or more dice, put a number of charge counters on Vexing Puzzlebox equal to the result.
{T}: Add one mana of any color. Roll a d20.
{T}, Remove 100 charge counters from Vexing Puzzlebox: Search your library for an artifact card, put that card onto the battlefield, then shuffle.

Arcum Dagsson

{T}: Target artifact creature's controller sacrifices it. That player may search their library for a noncreature artifact card, put it onto the battlefield, then shuffle.

Reshape

As an additional cost to cast this spell, sacrifice an artifact.
Search your library for an artifact card with mana value X or less, put it onto the battlefield, then shuffle.

Lich's Mirror

If you would lose the game, instead shuffle your hand, your graveyard, and all permanents you own into your library, then draw seven cards and your life total becomes 20.

Tamiyo's Journal

At the beginning of your upkeep, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
{T}, Sacrifice three Clues: Search your library for a card, put that card into your hand, then shuffle.

Whir of Invention

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
Search your library for an artifact card with mana value X or less, put it onto the battlefield, then shuffle.

Lich's Tomb

You don't lose the game for having 0 or less life.
Whenever you lose life, sacrifice a permanent for each 1 life you lost. (Damage causes loss of life.)

Myr Turbine

{T}: Create a 1/1 colorless Myr artifact creature token.
{T}, Tap five untapped Myr you control: Search your library for a Myr creature card, put it onto the battlefield, then shuffle.

Myr Incubator

{6}, {T}, Sacrifice Myr Incubator: Search your library for any number of artifact cards, exile them, then create that many 1/1 colorless Myr artifact creature tokens. Then shuffle.

Varina, Lich Queen

Whenever you attack with one or more Zombies, draw that many cards, then discard that many cards. You gain that much life.
{2}, Exile two cards from your graveyard: Create a tapped 2/2 black Zombie creature token.

Trophy Mage

When Trophy Mage enters the battlefield, you may search your library for an artifact card with mana value 3, reveal it, put it into your hand, then shuffle.

Tribute Mage

When Tribute Mage enters the battlefield, you may search your library for an artifact card with mana value 2, reveal that card, put it into your hand, then shuffle.