Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Polluted Delta

{T}, Pay 1 life, Sacrifice Polluted Delta: Search your library for an Island or Swamp card, put it onto the battlefield, then shuffle.

Chasm Skulker

Whenever you draw a card, put a +1/+1 counter on Chasm Skulker.
When Chasm Skulker dies, create X 1/1 blue Squid creature tokens with islandwalk, where X is the number of +1/+1 counters on Chasm Skulker. (They can't be blocked as long as defending player controls an Island.)

Toothy, Imaginary Friend

Partner with Pir, Imaginative Rascal (When this creature enters the battlefield, target player may put Pir into their hand from their library, then shuffle.)
Whenever you draw a card, put a +1/+1 counter on Toothy, Imaginary Friend.
When Toothy leaves the battlefield, draw a card for each +1/+1 counter on it.

Karlov of the Ghost Council

Whenever you gain life, put two +1/+1 counters on Karlov of the Ghost Council.
{W}{B}, Remove six +1/+1 counters from Karlov of the Ghost Council: Exile target creature.

Archmage Ascension

At the beginning of each end step, if you drew two or more cards this turn, you may put a quest counter on Archmage Ascension.
As long as Archmage Ascension has six or more quest counters on it, if you would draw a card, you may instead search your library for a card, put that card into your hand, then shuffle.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Debtors' Knell

({W/B} can be paid with either {W} or {B}.)
At the beginning of your upkeep, put target creature card from a graveyard onto the battlefield under your control.

Mirrormade

You may have Mirrormade enter the battlefield as a copy of any artifact or enchantment on the battlefield.

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Glacial Fortress

Glacial Fortress enters the battlefield tapped unless you control a Plains or an Island.
{T}: Add {W} or {U}.

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Laboratory Maniac

If you would draw a card while your library has no cards in it, you win the game instead.

Orzhov Signet

Prismatic Vista

{T}, Pay 1 life, Sacrifice Prismatic Vista: Search your library for a basic land card, put it onto the battlefield, then shuffle.

Ivory Tower

At the beginning of your upkeep, you gain X life, where X is the number of cards in your hand minus 4.

Spawn of Mayhem

Spectacle {1}{B}{B} (You may cast this spell for its spectacle cost rather than its mana cost if an opponent lost life this turn.)
Flying, trample
At the beginning of your upkeep, Spawn of Mayhem deals 1 damage to each player. Then if you have 10 or less life, put a +1/+1 counter on Spawn of Mayhem.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Lighthouse Chronologist

Level up {U} ({U}: Put a level counter on this. Level up only as a sorcery.)
LEVEL 4-6
2/4
LEVEL 7+
3/5
At the beginning of each end step, if it's not your turn, take an extra turn after this one.

Hallowed Fountain

({T}: Add {W} or {U}.)
As Hallowed Fountain enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Oneirophage

Flying
Whenever you draw a card, put a +1/+1 counter on Oneirophage.

Command Tower

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Indulgent Tormentor

Flying
At the beginning of your upkeep, draw a card unless target opponent sacrifices a creature or pays 3 life.

Island

Drowned Catacomb

Drowned Catacomb enters the battlefield tapped unless you control an Island or a Swamp.
{T}: Add {U} or {B}.

Jace's Erasure

Whenever you draw a card, you may have target player mill a card.

Isolated Chapel

Isolated Chapel enters the battlefield tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Estrid's Invocation

You may have Estrid's Invocation enter the battlefield as a copy of an enchantment you control, except it has "At the beginning of your upkeep, you may exile this enchantment. If you do, return it to the battlefield under its owner's control."

Sea of Clouds

Sea of Clouds enters the battlefield tapped unless you have two or more opponents.
{T}: Add {W} or {U}.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Dimir Signet

Marsh Flats

{T}, Pay 1 life, Sacrifice Marsh Flats: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Ajani's Pridemate

Whenever you gain life, put a +1/+1 counter on Ajani's Pridemate.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Bitterblossom

At the beginning of your upkeep, you lose 1 life and create a 1/1 black Faerie Rogue creature token with flying.

Rhox Faithmender

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
If you would gain life, you gain twice that much life instead.

Copy Enchantment

You may have Copy Enchantment enter the battlefield as a copy of any enchantment on the battlefield.

Angel of Vitality

Flying
If you would gain life, you gain that much life plus 1 instead.
Angel of Vitality gets +2/+2 as long as you have 25 or more life.

Swamp

Sol Ring

Paradox Haze

Enchant player
At the beginning of enchanted player's first upkeep each turn, that player gets an additional upkeep step after this step.

Boon Reflection

If you would gain life, you gain twice that much life instead.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Twinblade Paladin

Whenever you gain life, put a +1/+1 counter on Twinblade Paladin.
As long as you have 25 or more life, Twinblade Paladin has double strike. (It deals both first-strike and regular combat damage.)

Sphere of Safety

Creatures can't attack you or planeswalkers you control unless their controller pays {X} for each of those creatures, where X is the number of enchantments you control.

Underground River

{T}: Add {C}.
{T}: Add {U} or {B}. Underground River deals 1 damage to you.

Plains

Drogskol Reaver

Flying, double strike, lifelink
Whenever you gain life, draw a card.

Adarkar Wastes

{T}: Add {C}.
{T}: Add {W} or {U}. Adarkar Wastes deals 1 damage to you.

Tamiyo's Journal

At the beginning of your upkeep, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
{T}, Sacrifice three Clues: Search your library for a card, put that card into your hand, then shuffle.

Fabled Passage

{T}, Sacrifice Fabled Passage: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle. Then if you control four or more lands, untap that land.

Jace's Projection

Whenever you draw a card, put a +1/+1 counter on Jace's Projection.
{3}{U}: Put a loyalty counter on target Jace planeswalker.

Reliquary Tower

Bloodbond Vampire

Whenever you gain life, put a +1/+1 counter on Bloodbond Vampire.

Clever Impersonator

You may have Clever Impersonator enter the battlefield as a copy of any nonland permanent on the battlefield.

Chromatic Lantern

Lands you control have "{T}: Add one mana of any color."
{T}: Add one mana of any color.

Gideon's Company

Whenever you gain life, put two +1/+1 counters on Gideon's Company.
{3}{W}: Put a loyalty counter on target Gideon planeswalker.

Oloro, Ageless Ascetic

At the beginning of your upkeep, you gain 2 life.
Whenever you gain life, you may pay {1}. If you do, draw a card and each opponent loses 1 life.
At the beginning of your upkeep, if Oloro, Ageless Ascetic is in the command zone, you gain 2 life.

Venser's Journal

You have no maximum hand size.
At the beginning of your upkeep, you gain 1 life for each card in your hand.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

As Foretold

At the beginning of your upkeep, put a time counter on As Foretold.
Once each turn, you may pay {0} rather than pay the mana cost for a spell you cast with mana value X or less, where X is the number of time counters on As Foretold.

Sphinx's Tutelage

Whenever you draw a card, target opponent mills two cards. If two nonland cards that share a color were milled this way, repeat this process.
{5}{U}: Draw a card, then discard a card.

Azorius Signet

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Pristine Talisman

Watery Grave

({T}: Add {U} or {B}.)
As Watery Grave enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Morphic Pool

Morphic Pool enters the battlefield tapped unless you have two or more opponents.
{T}: Add {U} or {B}.

Archangel of Thune

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Whenever you gain life, put a +1/+1 counter on each creature you control.

Cyclonic Rift

Return target nonland permanent you don't control to its owner's hand.
Overload {6}{U} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Flooded Strand

{T}, Pay 1 life, Sacrifice Flooded Strand: Search your library for a Plains or Island card, put it onto the battlefield, then shuffle.

Evolving Wilds

{T}, Sacrifice Evolving Wilds: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Thassa, God of the Sea

Indestructible
As long as your devotion to blue is less than five, Thassa isn't a creature. (Each {U} in the mana costs of permanents you control counts toward your devotion to blue.)
At the beginning of your upkeep, scry 1.
{1}{U}: Target creature you control can't be blocked this turn.