Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Heartstone

Activated abilities of creatures cost {1} less to activate. This effect can't reduce the mana in that cost to less than one mana.

Sire of Insanity

At the beginning of each end step, each player discards their hand.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Fell Specter

Flying
When this creature enters, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Xantcha, Sleeper Agent

Xantcha enters under the control of an opponent of your choice.
Xantcha attacks each combat if able and can't attack its owner or planeswalkers its owner controls.
{3}: Xantcha's controller loses 2 life and you draw a card. Any player may activate this ability.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Rakdos Charm

Choose one —
• Exile target player's graveyard.
• Destroy target artifact.
• Each creature deals 1 damage to its controller.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Burglar Rat

When this creature enters, each opponent discards a card.

Oppression

Whenever a player casts a spell, that player discards a card.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Tinybones, Trinket Thief

At the beginning of each end step, if an opponent discarded a card this turn, you draw a card and you lose 1 life.
{4}{B}{B}: Each opponent with no cards in hand loses 10 life.

Bedevil

Destroy target artifact, creature, or planeswalker.

Megrim

Whenever an opponent discards a card, this enchantment deals 2 damage to that player.

Court of Ambition

When this enchantment enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.