Ledger Shredder

Flying
Whenever a player casts their second spell each turn, Ledger Shredder connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on this creature.)

Mad Ratter

Whenever you draw your second card each turn, create two 1/1 black Rat creature tokens.

Rose Room Treasurer

Alliance — Whenever another creature you control enters, create a Treasure token if this is the first or second time this ability has resolved this turn. Otherwise, you may pay {X}. When you do, Rose Room Treasurer deals X damage to any target.

Jori En, Ruin Diver

Whenever you cast your second spell each turn, draw a card.

Bury in Books

This spell costs {2} less to cast if it targets an attacking creature.
Put target creature into its owner's library second from the top.

Rumor Gatherer

Alliance — Whenever another creature you control enters, scry 1. If this is the second time this ability has resolved this turn, draw a card instead.

Mantle of Tides

Equipped creature gets +1/+2.
Whenever you draw your second card each turn, attach Mantle of Tides to target creature you control.
Equip {3} ({3}: Attach to target creature you control. Equip only as a sorcery.)

Kraum, Ludevic's Opus

Flying, haste
Whenever an opponent casts their second spell each turn, draw a card.
Partner (You can have two commanders if both have partner.)

Minn, Wily Illusionist

Whenever you draw your second card each turn, create a 1/1 blue Illusion creature token with "This creature gets +1/+0 for each other Illusion you control."
Whenever an Illusion you control dies, you may put a permanent card with mana value less than or equal to that creature's power from your hand onto the battlefield.

Rite of Ruin

Choose an order for artifacts, creatures, and lands. Each player sacrifices one permanent of the first type, sacrifices two of the second type, then sacrifices three of the third type.

Tomb of Horrors Adventurer

When Tomb of Horrors Adventurer enters, you take the initiative.
Whenever you cast your second spell each turn, copy it. If you've completed a dungeon, copy that spell twice instead. You may choose new targets for the copies. (A copy of a permanent spell becomes a token.)

Irencrag Pyromancer

Whenever you draw your second card each turn, Irencrag Pyromancer deals 3 damage to any target.

Memory

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Each player shuffles their hand and graveyard into their library, then draws seven cards.

Commit

Put target spell or nonland permanent into its owner's library second from the top.

Commit // Memory

Codespell Cleric

Vigilance
When Codespell Cleric enters, if it was the second spell you cast this turn, put a +1/+1 counter on target creature.

Approach of the Second Sun

If this spell was cast from your hand and you've cast another spell named Approach of the Second Sun this game, you win the game. Otherwise, put Approach of the Second Sun into its owner's library seventh from the top and you gain 7 life.

Gavi, Nest Warden

You may pay {0} rather than pay the cycling cost of the first card you cycle each turn.
Whenever you draw your second card each turn, create a 2/2 red and white Dinosaur Cat creature token.

Omnath, Locus of Creation

When Omnath, Locus of Creation enters, draw a card.
Landfall — Whenever a land you control enters, you gain 4 life if this is the first time this ability has resolved this turn. If it's the second time, add {R}{G}{W}{U}. If it's the third time, Omnath deals 4 damage to each opponent and each planeswalker you don't control.

The Council of Four

Whenever a player draws their second card during their turn, you draw a card.
Whenever a player casts their second spell during their turn, you create a 2/2 white Knight creature token.

Clarion Spirit

Whenever you cast your second spell each turn, create a 1/1 white Spirit creature token with flying.

Monk Class

(Gain the next level as a sorcery to add its ability.)
The second spell you cast each turn costs {1} less to cast.
{W}{U}: Level 2
When this Class becomes level 2, return up to one target nonland permanent to its owner's hand.
{1}{W}{U}: Level 3
At the beginning of your upkeep, exile the top card of your library. For as long as it remains exiled, it has "You may cast this card from exile as long as you've cast another spell this turn."

Oust

Put target creature into its owner's library second from the top. Its controller gains 3 life.

Jace, Arcane Strategist

Whenever you draw your second card each turn, put a +1/+1 counter on target creature you control.
+1: Draw a card.
−7: Creatures you control can't be blocked this turn.

Ethereal Investigator

Flying
When Ethereal Investigator enters, investigate X times, where X is the number of opponents you have. (To investigate, create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
Whenever you draw your second card each turn, create a 1/1 white Spirit creature token with flying.

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Second Guess

Counter target spell that's the second spell cast this turn.

Mangara, the Diplomat

Lifelink
Whenever an opponent attacks with creatures, if two or more of those creatures are attacking you and/or planeswalkers you control, draw a card.
Whenever an opponent casts their second spell each turn, draw a card.

Gluntch, the Bestower

Flying
At the beginning of your end step, choose a player. They put two +1/+1 counters on a creature they control. Choose a second player to draw a card. Then choose a third player to create two Treasure tokens.

Improbable Alliance

Whenever you draw your second card each turn, create a 1/1 blue Faerie creature token with flying.
{4}{U}{R}: Draw a card, then discard a card.

Howling Moon

At the beginning of combat on your turn, target Wolf or Werewolf you control gets +2/+2 until end of turn.
Whenever an opponent casts their second spell each turn, create a 2/2 green Wolf creature token.

Jolrael, Mwonvuli Recluse

Whenever you draw your second card each turn, create a 2/2 green Cat creature token.
{4}{G}{G}: Until end of turn, creatures you control have base power and toughness X/X, where X is the number of cards in your hand.

Pyromancer's Assault

Whenever you cast your second spell each turn, Pyromancer's Assault deals 2 damage to any target.

Oji, the Exquisite Blade

When Oji, the Exquisite Blade enters, you gain 2 life and scry 2.
Whenever you cast your second spell each turn, exile up to one target creature you control, then return it to the battlefield under its owner's control.

Elmar, Ulvenwald Informant

Haste
Whenever you cast your second spell each turn, untap target creature, then investigate. (Create a colorless Clue artifact token with "{2}, Sacrifice this artifact: Draw a card.")
Friends forever (You can have two commanders if both have friends forever.)

Oath of Mages

At the beginning of each player's upkeep, that player chooses target player who has more life than they do and is their opponent. The first player may have Oath of Mages deal 1 damage to the second player.