Damnation

Destroy all creatures. They can't be regenerated.

Radiant Fountain

When Radiant Fountain enters, you gain 2 life.
{T}: Add {C}.

Imperial Seal

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Test of Endurance

At the beginning of your upkeep, if you have 50 or more life, you win the game.

Thran Dynamo

Fountain of Renewal

At the beginning of your upkeep, you gain 1 life.
{3}, Sacrifice Fountain of Renewal: Draw a card.

Orzhov Signet

Cradle of Vitality

Whenever you gain life, you may pay {1}{W}. If you do, put a +1/+1 counter on target creature for each 1 life you gained.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Queza, Augur of Agonies

Whenever you draw a card, target opponent loses 1 life and you gain 1 life.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

The Book of Exalted Deeds

At the beginning of your end step, if you gained 3 or more life this turn, create a 3/3 white Angel creature token with flying.
{W}{W}{W}, {T}, Exile The Book of Exalted Deeds: Put an enlightened counter on target Angel. It gains "You can't lose the game and your opponents can't win the game." Activate only as a sorcery.

Raffine's Tower

({T}: Add {W}, {U}, or {B}.)
Raffine's Tower enters tapped.
Cycling {3} ({3}, Discard this card: Draw a card.)

Esper Panorama

{T}: Add {C}.
{1}, {T}, Sacrifice Esper Panorama: Search your library for a basic Plains, Island, or Swamp card, put it onto the battlefield tapped, then shuffle.

Alhammarret, High Arbiter

Flying
As Alhammarret, High Arbiter enters, each opponent reveals their hand. You choose the name of a nonland card revealed this way.
Your opponents can't cast spells with the chosen name (as long as this creature is on the battlefield).

Doom Blade

Panharmonicon

If an artifact or creature entering causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Obscura Storefront

When Obscura Storefront enters, sacrifice it. When you do, search your library for a basic Plains, Island, or Swamp card, put it onto the battlefield tapped, then shuffle and you gain 1 life.

Shipwreck Marsh

Shipwreck Marsh enters tapped unless you control two or more other lands.
{T}: Add {U} or {B}.

Pull from Eternity

Put target face-up exiled card into its owner's graveyard.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is Esper Sentinel's power.

Maze of Ith

{T}: Untap target attacking creature. Prevent all combat damage that would be dealt to and dealt by that creature this turn.

Dark Ritual

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Archangel of Thune

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Whenever you gain life, put a +1/+1 counter on each creature you control.

Teferi, Master of Time

You may activate loyalty abilities of Teferi, Master of Time on any player's turn any time you could cast an instant.
+1: Draw a card, then discard a card.
−3: Target creature you don't control phases out. (Treat it and anything attached to it as though they don't exist until its controller's next turn.)
−10: Take two extra turns after this one.

Prairie Stream

({T}: Add {W} or {U}.)
Prairie Stream enters tapped unless you control two or more basic lands.

Cleric Class

(Gain the next level as a sorcery to add its ability.)
If you would gain life, you gain that much life plus 1 instead.
{3}{W}: Level 2
Whenever you gain life, put a +1/+1 counter on target creature you control.
{4}{W}: Level 3
When this Class becomes level 3, return target creature card from your graveyard to the battlefield. You gain life equal to that creature's toughness.

Ajani's Pridemate

Whenever you gain life, put a +1/+1 counter on Ajani's Pridemate.

Swift End

Destroy target creature or planeswalker. You lose 2 life. (Then exile this card. You may cast the creature later from exile.)

Murderous Rider

Lifelink
When Murderous Rider dies, put it on the bottom of its owner's library.

Murderous Rider // Swift End

Cryptic Command

Choose two —
• Counter target spell.
• Return target permanent to its owner's hand.
• Tap all creatures your opponents control.
• Draw a card.

Pristine Talisman

Darksteel Ingot

Indestructible (Effects that say "destroy" don't destroy this artifact.)
{T}: Add one mana of any color.

Mirrormade

You may have Mirrormade enter as a copy of any artifact or enchantment on the battlefield.

Mystic Confluence

Choose three. You may choose the same mode more than once.
• Counter target spell unless its controller pays {3}.
• Return target creature to its owner's hand.
• Draw a card.

Nyxbloom Ancient

Trample
If you tap a permanent for mana, it produces three times as much of that mana instead.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Flooded Strand

{T}, Pay 1 life, Sacrifice Flooded Strand: Search your library for a Plains or Island card, put it onto the battlefield, then shuffle.

Solemn Simulacrum

When Solemn Simulacrum enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When Solemn Simulacrum dies, you may draw a card.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Soul Warden

Whenever another creature enters, you gain 1 life.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Absorb

Force of Will

You may pay 1 life and exile a blue card from your hand rather than pay this spell's mana cost.
Counter target spell.

Archaeomancer

When Archaeomancer enters, return target instant or sorcery card from your graveyard to your hand.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Noble Purpose

Whenever a creature you control deals combat damage, you gain that much life.

Drogskol Reaver

Flying, double strike, lifelink
Whenever you gain life, draw a card.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Gilded Lotus

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Thopter Foundry

{1}, Sacrifice a nontoken artifact: Create a 1/1 blue Thopter artifact creature token with flying. You gain 1 life.

Reality Ripple

Target artifact, creature, or land phases out. (While it's phased out, it's treated as though it doesn't exist. It phases in before its controller untaps during their next untap step.)

Force of Negation

If it's not your turn, you may exile a blue card from your hand rather than pay this spell's mana cost.
Counter target noncreature spell. If that spell is countered this way, exile it instead of putting it into its owner's graveyard.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Silence

Your opponents can't cast spells this turn.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Nyx Lotus

Nyx Lotus enters tapped.
{T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Crawlspace

No more than two creatures can attack you each combat.

Karmic Guide

Flying, protection from black
Echo {3}{W}{W} (At the beginning of your upkeep, if this came under your control since the beginning of your last upkeep, sacrifice it unless you pay its echo cost.)
When Karmic Guide enters, return target creature card from your graveyard to the battlefield.

Brainstorm

Draw three cards, then put two cards from your hand on top of your library in any order.

Watery Grave

({T}: Add {U} or {B}.)
As Watery Grave enters, you may pay 2 life. If you don't, it enters tapped.

Spirit Link

Enchant creature (Target a creature as you cast this. This card enters attached to that creature.)
Whenever enchanted creature deals damage, you gain that much life.

Obzedat, Ghost Council

When Obzedat, Ghost Council enters, target opponent loses 2 life and you gain 2 life.
At the beginning of your end step, you may exile Obzedat. If you do, return it to the battlefield under its owner's control at the beginning of your next upkeep. It gains haste.

Hall of Heliod's Generosity

{T}: Add {C}.
{1}{W}, {T}: Put target enchantment card from your graveyard on top of your library.

Rune-Tail's Essence

Prevent all damage that would be dealt to creatures you control.

Rune-Tail, Kitsune Ascendant

When you have 30 or more life, flip Rune-Tail, Kitsune Ascendant.

Rune-Tail, Kitsune Ascendant // Rune-Tail's Essence

Sun Titan

Vigilance
Whenever Sun Titan enters or attacks, you may return target permanent card with mana value 3 or less from your graveyard to the battlefield.

Fabled Passage

{T}, Sacrifice Fabled Passage: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle. Then if you control four or more lands, untap that land.

Felidar Sovereign

Vigilance, lifelink
At the beginning of your upkeep, if you have 40 or more life, you win the game.

Mana Drain

Counter target spell. At the beginning of your next main phase, add an amount of {C} equal to that spell's mana value.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Teysa, Envoy of Ghosts

Vigilance, protection from creatures
Whenever a creature deals combat damage to you, destroy that creature. Create a 1/1 white and black Spirit creature token with flying.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Plains

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Suture Priest

Whenever another creature you control enters, you may gain 1 life.
Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Arcane Sanctum

Arcane Sanctum enters tapped.
{T}: Add {W}, {U}, or {B}.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters, you may pay 2 life. If you don't, it enters tapped.

Dovin's Veto

This spell can't be countered.
Counter target noncreature spell.

Nykthos Paragon

Whenever you gain life, you may put that many +1/+1 counters on each creature you control. Do this only once each turn.

Sunken Ruins

{T}: Add {C}.
{U/B}, {T}: Add {U}{U}, {U}{B}, or {B}{B}.

Merchant Scroll

Search your library for a blue instant card, reveal that card, put it into your hand, then shuffle.

Blood Reckoning

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.

Rhox Faithmender

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
If you would gain life, you gain twice that much life instead.

Chrome Mox

Imprint — When Chrome Mox enters, you may exile a nonartifact, nonland card from your hand.
{T}: Add one mana of any of the exiled card's colors.

Negate

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Boon Reflection

If you would gain life, you gain twice that much life instead.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Karlov of the Ghost Council

Whenever you gain life, put two +1/+1 counters on Karlov of the Ghost Council.
{W}{B}, Remove six +1/+1 counters from Karlov of the Ghost Council: Exile target creature.

Counterspell

Polluted Delta

{T}, Pay 1 life, Sacrifice Polluted Delta: Search your library for an Island or Swamp card, put it onto the battlefield, then shuffle.

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Worn Powerstone

Worn Powerstone enters tapped.
{T}: Add {C}{C}.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.