Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Hatred

As an additional cost to cast this spell, pay X life.
Target creature gets +X/+0 until end of turn.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Professor Onyx

Magecraft — Whenever you cast or copy an instant or sorcery spell, each opponent loses 2 life and you gain 2 life.
+1: You lose 1 life. Look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
−3: Each opponent sacrifices a creature with the greatest power among creatures that player controls.
−8: Each opponent may discard a card. If they don't, they lose 3 life. Repeat this process six more times.

Worn Powerstone

Worn Powerstone enters tapped.
{T}: Add {C}{C}.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Sol Ring

Dismantling Wave

For each opponent, destroy up to one target artifact or enchantment that player controls.
Cycling {6}{W}{W} ({6}{W}{W}, Discard this card: Draw a card.)
When you cycle Dismantling Wave, destroy all artifacts and enchantments.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Ignite the Beacon

Search your library for up to two planeswalker cards, reveal them, put them into your hand, then shuffle.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Aura of Silence

Artifact and enchantment spells your opponents cast cost {2} more to cast.
Sacrifice Aura of Silence: Destroy target artifact or enchantment.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Rhox Faithmender

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
If you would gain life, you gain twice that much life instead.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Inkshield

Prevent all combat damage that would be dealt to you this turn. For each 1 damage prevented this way, create a 2/1 white and black Inkling creature token with flying.

Hushbringer

Flying, lifelink
Creatures entering or dying don't cause abilities to trigger.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Kaya's Guile

Choose two —
• Each opponent sacrifices a creature of their choice.
• Exile all opponents' graveyards.
• Create a 1/1 white and black Spirit creature token with flying.
• You gain 4 life.
Entwine {3} (Choose all if you pay the entwine cost.)

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Lolth, Spider Queen

Whenever a creature you control dies, put a loyalty counter on Lolth, Spider Queen.
0: You draw a card and you lose 1 life.
−3: Create two 2/1 black Spider creature tokens with menace and reach.
−8: You get an emblem with "Whenever an opponent is dealt combat damage by one or more creatures you control, if that player lost less than 8 life this turn, they lose life equal to the difference."

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Vanishing Verse

Kaya, Ghost Assassin

0: Exile Kaya, Ghost Assassin or up to one target creature. Return that card to the battlefield under its owner's control at the beginning of your next upkeep. You lose 2 life.
−1: Each opponent loses 2 life and you gain 2 life.
−2: Each opponent discards a card and you draw a card.

Soul Shatter

Each opponent sacrifices a creature or planeswalker with the highest mana value among creatures and planeswalkers they control.

Congregate

Target player gains 2 life for each creature on the battlefield.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Mana Tithe

Counter target spell unless its controller pays {1}.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Moonlight Bargain

Look at the top five cards of your library. For each card, put that card into your graveyard unless you pay 2 life. Then put the rest into your hand.

Kaya, Orzhov Usurper

+1: Exile up to two target cards from a single graveyard. You gain 2 life if at least one creature card was exiled this way.
−1: Exile target nonland permanent with mana value 1 or less.
−5: Kaya, Orzhov Usurper deals damage to target player equal to the number of cards that player owns in exile and you gain that much life.

Sorin, Grim Nemesis

+1: Reveal the top card of your library and put that card into your hand. Each opponent loses life equal to its mana value.
−X: Sorin, Grim Nemesis deals X damage to target creature or planeswalker and you gain X life.
−9: Create a number of 1/1 black Vampire Knight creature tokens with lifelink equal to the highest life total among all players.

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Tevesh Szat, Doom of Fools

+2: Create two 0/1 black Thrull creature tokens.
+1: You may sacrifice another creature or planeswalker. If you do, draw two cards, then draw another card if the sacrificed permanent was a commander.
−10: Gain control of all commanders. Put all commanders from the command zone onto the battlefield under your control.
Tevesh Szat, Doom of Fools can be your commander.
Partner

Liliana, Dreadhorde General

Whenever a creature you control dies, draw a card.
+1: Create a 2/2 black Zombie creature token.
−4: Each player sacrifices two creatures of their choice.
−9: Each opponent chooses a permanent they control of each permanent type and sacrifices the rest.

Rest in Peace

When Rest in Peace enters, exile all graveyards.
If a card or token would be put into a graveyard from anywhere, exile it instead.

Orzhov Signet

Skyclave Relic

Kicker {3}
Indestructible
When Skyclave Relic enters, if it was kicked, create two tapped tokens that are copies of Skyclave Relic.
{T}: Add one mana of any color.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Ondu Skyruins

Ondu Skyruins enters tapped.
{T}: Add {W}.

Ondu Inversion

Ondu Inversion // Ondu Skyruins

Command the Dreadhorde

Choose any number of target creature and/or planeswalker cards in graveyards. Command the Dreadhorde deals damage to you equal to the total mana value of those cards. Put them onto the battlefield under your control.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

The Celestus

If it's neither day nor night, it becomes day as The Celestus enters.
{T}: Add one mana of any color.
{3}, {T}: If it's night, it becomes day. Otherwise, it becomes night. Activate only as a sorcery.
Whenever day becomes night or night becomes day, you gain 1 life. You may draw a card. If you do, discard a card.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Ashes of the Abhorrent

Players can't cast spells from graveyards or activate abilities of cards in graveyards.
Whenever a creature dies, you gain 1 life.

Boon Reflection

If you would gain life, you gain twice that much life instead.

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Stinging Study

You draw X cards and you lose X life, where X is the mana value of a commander you own on the battlefield or in the command zone.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Mangara, the Diplomat

Lifelink
Whenever an opponent attacks with creatures, if two or more of those creatures are attacking you and/or planeswalkers you control, draw a card.
Whenever an opponent casts their second spell each turn, draw a card.

Despark

Exile target permanent with mana value 4 or greater.

Infernal Grasp

Destroy target creature. You lose 2 life.

Wrath of God

Destroy all creatures. They can't be regenerated.

Cleric Class

(Gain the next level as a sorcery to add its ability.)
If you would gain life, you gain that much life plus 1 instead.
{3}{W}: Level 2
Whenever you gain life, put a +1/+1 counter on target creature you control.
{4}{W}: Level 3
When this Class becomes level 3, return target creature card from your graveyard to the battlefield. You gain life equal to that creature's toughness.

Aven Mindcensor

Flash
Flying
If an opponent would search a library, that player searches the top four cards of that library instead.

Dark Ritual

Takenuma, Abandoned Mire

{T}: Add {B}.
Channel — {3}{B}, Discard Takenuma, Abandoned Mire: Mill three cards, then return a creature or planeswalker card from your graveyard to your hand. This ability costs {1} less to activate for each legendary creature you control.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Wretched Confluence

Choose three. You may choose the same mode more than once.
• Target player draws a card and loses 1 life.
• Target creature gets -2/-2 until end of turn.
• Return target creature card from your graveyard to your hand.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Eiganjo, Seat of the Empire

{T}: Add {W}.
Channel — {2}{W}, Discard Eiganjo, Seat of the Empire: It deals 4 damage to target attacking or blocking creature. This ability costs {1} less to activate for each legendary creature you control.