Time Wipe

Return a creature you control to its owner's hand, then destroy all creatures.

Mirari's Wake

Creatures you control get +1/+1.
Whenever you tap a land for mana, add one mana of any type that land produced.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

The Meathook Massacre

When The Meathook Massacre enters, each creature gets -X/-X until end of turn.
Whenever a creature you control dies, each opponent loses 1 life.
Whenever a creature an opponent controls dies, you gain 1 life.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Damnation

Destroy all creatures. They can't be regenerated.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Ruinous Ultimatum

Destroy all nonland permanents your opponents control.

Zendikar Resurgent

Whenever you tap a land for mana, add one mana of any type that land produced. (The types of mana are white, blue, black, red, green, and colorless.)
Whenever you cast a creature spell, draw a card.

Wrath of God

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Codie, Vociferous Codex

You can't cast permanent spells.
{4}, {T}: Add {W}{U}{B}{R}{G}. When you next cast a spell this turn, exile cards from the top of your library until you exile an instant or sorcery card with lesser mana value. Until end of turn, you may cast that card without paying its mana cost. Put each other card exiled this way on the bottom of your library in a random order.

Caged Sun

As Caged Sun enters, choose a color.
Creatures you control of the chosen color get +1/+1.
Whenever a land's ability causes you to add one or more mana of the chosen color, add one additional mana of that color.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

By Invitation Only

Choose a number between 0 and 13. Each player sacrifices that many creatures of their choice.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Sol Ring

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Ezuri's Predation

For each creature your opponents control, create a 4/4 green Phyrexian Beast creature token. Each of those tokens fights a different one of those creatures.

Chain Reaction

Chain Reaction deals X damage to each creature, where X is the number of creatures on the battlefield.

Rolling Earthquake

Rolling Earthquake deals X damage to each creature without horsemanship and each player.