Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Sign in Blood

Target player draws two cards and loses 2 life.

Rakdos, the Showstopper

Flying, trample
When Rakdos, the Showstopper enters, flip a coin for each creature that isn't a Demon, Devil, or Imp. Destroy each creature whose coin comes up tails.

Vexing Devil

When Vexing Devil enters, any opponent may have it deal 4 damage to them. If a player does, sacrifice Vexing Devil.

Curse of Hospitality

Enchant player
Creatures attacking enchanted player have trample.
Whenever a creature deals combat damage to enchanted player, that player exiles the top card of their library. Until end of turn, that creature's controller may play that card and they may spend mana as though it were mana of any color to cast that spell.

Morbid Opportunist

Whenever one or more other creatures die, draw a card. This ability triggers only once each turn.

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Curse of Fool's Wisdom

Enchant player
Whenever enchanted player draws a card, they lose 2 life and you gain 2 life.
Madness {3}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Kardur, Doomscourge

When Kardur, Doomscourge enters, until your next turn, creatures your opponents control attack each combat if able and attack a player other than you if able.
Whenever an attacking creature dies, each opponent loses 1 life and you gain 1 life.

Liliana, Death Mage

+1: Return up to one target creature card from your graveyard to your hand.
−3: Destroy target creature. Its controller loses 2 life.
−7: Target opponent loses 2 life for each creature card in their graveyard.

Anger

Haste
As long as Anger is in your graveyard and you control a Mountain, creatures you control have haste.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Undying Malice

Until end of turn, target creature gains "When this creature dies, return it to the battlefield tapped under its owner's control with a +1/+1 counter on it."