Soul Barrier

Whenever an opponent casts a creature spell, Soul Barrier deals 2 damage to that player unless they pay {2}.

Pain Magnification

Whenever an opponent is dealt 3 or more damage by a single source, that player discards a card.

Rewards of Diversity

Whenever an opponent casts a multicolored spell, you gain 4 life.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Cosi's Trickster

Whenever an opponent shuffles their library, you may put a +1/+1 counter on Cosi's Trickster.

Revel in Silence

Your opponents can't cast spells or activate planeswalkers' loyalty abilities this turn.
Exile Revel in Silence.

Flamescroll Celebrant

Whenever an opponent activates an ability that isn't a mana ability, Flamescroll Celebrant deals 1 damage to that player.
{1}{R}: Flamescroll Celebrant gets +2/+0 until end of turn.

Flamescroll Celebrant // Revel in Silence

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Cunning Rhetoric

Whenever an opponent attacks you and/or one or more planeswalkers you control, exile the top card of that player's library. You may play that card for as long as it remains exiled, and you may spend mana as though it were mana of any color to cast it.

Captured by the Consulate

Enchant creature you don't control
Enchanted creature can't attack.
Whenever an opponent casts a spell, if it has a single target, change the target to enchanted creature if able.

Cindervines

Whenever an opponent casts a noncreature spell, Cindervines deals 1 damage to that player.
{1}, Sacrifice Cindervines: Destroy target artifact or enchantment. Cindervines deals 2 damage to that permanent's controller.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Spelltithe Enforcer

Whenever an opponent casts a spell, that player sacrifices a permanent unless they pay {1}.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Chandra's Spitfire

Flying
Whenever an opponent is dealt noncombat damage, Chandra's Spitfire gets +3/+0 until end of turn.

Counterbalance

Whenever an opponent casts a spell, you may reveal the top card of your library. If you do, counter that spell if it has the same mana value as the revealed card.

Ghostly Pilferer

Whenever Ghostly Pilferer becomes untapped, you may pay {2}. If you do, draw a card.
Whenever an opponent casts a spell from anywhere other than their hand, draw a card.
Discard a card: Ghostly Pilferer can't be blocked this turn.

Warmth

Whenever an opponent casts a red spell, you gain 2 life.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Ever-Watching Threshold

Whenever an opponent attacks, if they attacked you and/or a planeswalker you control, draw a card.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Infested Roothold

Defender (This creature can't attack.)
Protection from artifacts
Whenever an opponent casts an artifact spell, you may create a 1/1 green Insect creature token.

Kederekt Parasite

Whenever an opponent draws a card, if you control a red permanent, you may have Kederekt Parasite deal 1 damage to that player.

Wildfire Elemental

Whenever an opponent is dealt noncombat damage, creatures you control get +1/+0 until end of turn.

Soldier of the Pantheon

Protection from multicolored
Whenever an opponent casts a multicolored spell, you gain 1 life.

Emberwilde Captain

When Emberwilde Captain enters the battlefield, you become the monarch.
Whenever an opponent attacks you while you're the monarch, Emberwilde Captain deals damage to that player equal to the number of cards in their hand.

War's Toll

Whenever an opponent taps a land for mana, tap all lands that player controls.
If a creature an opponent controls attacks, all creatures that opponent controls attack if able.

Kavu Predator

Trample
Whenever an opponent gains life, put that many +1/+1 counters on Kavu Predator.

Harsh Justice

Cast this spell only during the declare attackers step and only if you've been attacked this step.
This turn, whenever an attacking creature deals combat damage to you, it deals that much damage to its controller.

Arasta of the Endless Web

Reach
Whenever an opponent casts an instant or sorcery spell, create a 1/2 green Spider creature token with reach.

Dragonlair Spider

Reach
Whenever an opponent casts a spell, create a 1/1 green Insect creature token.

Vorinclex, Voice of Hunger

Trample
Whenever you tap a land for mana, add one mana of any type that land produced.
Whenever an opponent taps a land for mana, that land doesn't untap during its controller's next untap step.

Abyssal Nocturnus

Whenever an opponent discards a card, Abyssal Nocturnus gets +2/+2 and gains fear until end of turn. (It can't be blocked except by artifact creatures and/or black creatures.)

Snake Pit

Whenever an opponent casts a blue or black spell, you may create a 1/1 green Snake creature token.

Treasure Nabber

Whenever an opponent taps an artifact for mana, gain control of that artifact until the end of your next turn.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Mogg Sentry

Whenever an opponent casts a spell, Mogg Sentry gets +2/+2 until end of turn.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Witchstalker

Hexproof (This creature can't be the target of spells or abilities your opponents control.)
Whenever an opponent casts a blue or black spell during your turn, put a +1/+1 counter on Witchstalker.

Deep-Sea Kraken

Deep-Sea Kraken can't be blocked.
Suspend 9—{2}{U} (Rather than cast this card from your hand, you may pay {2}{U} and exile it with nine time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost. It has haste.)
Whenever an opponent casts a spell, if Deep-Sea Kraken is suspended, remove a time counter from it.

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Sunscorch Regent and you gain 1 life.

Harsh Mentor

Whenever an opponent activates an ability of an artifact, creature, or land on the battlefield, if it isn't a mana ability, Harsh Mentor deals 2 damage to that player.

Nekusar, the Mindrazer

At the beginning of each player's draw step, that player draws an additional card.
Whenever an opponent draws a card, Nekusar, the Mindrazer deals 1 damage to that player.

Wedding Ring

When Wedding Ring enters the battlefield, if it was cast, target opponent creates a token that's a copy of it.
Whenever an opponent who controls an artifact named Wedding Ring draws a card during their turn, you draw a card.
Whenever an opponent who controls an artifact named Wedding Ring gains life during their turn, you gain that much life.

Mangara, the Diplomat

Lifelink
Whenever an opponent attacks with creatures, if two or more of those creatures are attacking you and/or planeswalkers you control, draw a card.
Whenever an opponent casts their second spell each turn, draw a card.

Citanul Druid

Whenever an opponent casts an artifact spell, put a +1/+1 counter on Citanul Druid.

Aether Sting

Whenever an opponent casts a creature spell, Aether Sting deals 1 damage to that player.

Acererak the Archlich

When Acererak the Archlich enters the battlefield, if you haven't completed Tomb of Annihilation, return Acererak the Archlich to its owner's hand and venture into the dungeon.
Whenever Acererak the Archlich attacks, for each opponent, you create a 2/2 black Zombie creature token unless that player sacrifices a creature.

Memory Erosion

Whenever an opponent casts a spell, that player mills two cards.

Mindsparker

First strike (This creature deals combat damage before creatures without first strike.)
Whenever an opponent casts a white or blue instant or sorcery spell, Mindsparker deals 2 damage to that player.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

First Day of Class

Whenever a creature enters the battlefield under your control this turn, put a +1/+1 counter on it and it gains haste until end of turn.
Learn. (You may reveal a Lesson card you own from outside the game and put it into your hand, or discard a card to draw a card.)

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Mold Adder

Whenever an opponent casts a blue or black spell, you may put a +1/+1 counter on Mold Adder.

Scab-Clan Berserker

Haste
Renown 1 (When this creature deals combat damage to a player, if it isn't renowned, put a +1/+1 counter on it and it becomes renowned.)
Whenever an opponent casts a noncreature spell, if Scab-Clan Berserker is renowned, Scab-Clan Berserker deals 2 damage to that player.

Lone Wolf of the Natterknolls

Whenever an opponent casts a spell during your turn, draw two cards.
At the beginning of each upkeep, if a player cast two or more spells last turn, transform Lone Wolf of the Natterknolls.

Hermit of the Natterknolls

Whenever an opponent casts a spell during your turn, draw a card.
At the beginning of each upkeep, if no spells were cast last turn, transform Hermit of the Natterknolls.

Hermit of the Natterknolls // Lone Wolf of the Natterknolls

Explore the Vastlands

Each player looks at the top five cards of their library and may reveal a land card and/or an instant or sorcery card from among them. Each player puts the cards they revealed this way into their hand and the rest on the bottom of their library in a random order. Each player gains 3 life.

Wandering Archaic

Whenever an opponent casts an instant or sorcery spell, they may pay {2}. If they don't, you may copy that spell. You may choose new targets for the copy.

Wandering Archaic // Explore the Vastlands

War Elemental

When War Elemental enters the battlefield, sacrifice it unless an opponent was dealt damage this turn.
Whenever an opponent is dealt damage, put that many +1/+1 counters on War Elemental.

Ishai, Ojutai Dragonspeaker

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Ishai, Ojutai Dragonspeaker.
Partner (You can have two commanders if both have partner.)

Taurean Mauler

Changeling (This card is every creature type.)
Whenever an opponent casts a spell, you may put a +1/+1 counter on Taurean Mauler.

Vial Smasher the Fierce

Whenever you cast your first spell each turn, choose an opponent at random. Vial Smasher the Fierce deals damage equal to that spell's mana value to that player or a planeswalker that player controls.
Partner (You can have two commanders if both have partner.)

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Sanctimony

Whenever an opponent taps a Mountain for mana, you may gain 1 life.

Malik, Grim Manipulator

When Malik, Grim Manipulator enters the battlefield, you and target opponent each secretly choose a creature that player controls. Then those choices are revealed, and that player sacrifices those creatures.
Whenever an opponent sacrifices a creature, you create a Treasure token.

Consecrated Sphinx

Flying
Whenever an opponent draws a card, you may draw two cards.

Ichneumon Druid

Whenever an opponent casts an instant spell other than the first instant spell that player casts each turn, Ichneumon Druid deals 4 damage to that player.

Burgeoning

Whenever an opponent plays a land, you may put a land card from your hand onto the battlefield.

Jace, Unraveler of Secrets

+1: Scry 1, then draw a card.
−2: Return target creature to its owner's hand.
−8: You get an emblem with "Whenever an opponent casts their first spell each turn, counter that spell."

Xyris, the Writhing Storm

Flying
Whenever an opponent draws a card except the first one they draw in each of their draw steps, create a 1/1 green Snake creature token.
Whenever Xyris, the Writhing Storm deals combat damage to a player, you and that player each draw that many cards.

Nath of the Gilt-Leaf

At the beginning of your upkeep, you may have target opponent discard a card at random.
Whenever an opponent discards a card, you may create a 1/1 green Elf Warrior creature token.

Kraum, Ludevic's Opus

Flying, haste
Whenever an opponent casts their second spell each turn, draw a card.
Partner (You can have two commanders if both have partner.)

Chimeric Egg

Whenever an opponent casts a nonartifact spell, put a charge counter on Chimeric Egg.
Remove three charge counters from Chimeric Egg: Chimeric Egg becomes a 6/6 Construct artifact creature with trample until end of turn.

Immolation Shaman

Whenever an opponent activates an ability of an artifact, creature, or land that isn't a mana ability, Immolation Shaman deals 1 damage to that player.
{3}{R}{R}: Immolation Shaman gets +3/+3 and gains menace until end of turn.

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters the battlefield, if it was kicked, target opponent discards two cards at random.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Runic Armasaur

Whenever an opponent activates an ability of a creature or land that isn't a mana ability, you may draw a card.

Punishing Fire

Punishing Fire deals 2 damage to any target.
Whenever an opponent gains life, you may pay {R}. If you do, return Punishing Fire from your graveyard to your hand.

Dirtcowl Wurm

Whenever an opponent plays a land, put a +1/+1 counter on Dirtcowl Wurm.

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis, Unshackled.

Howling Moon

At the beginning of combat on your turn, target Wolf or Werewolf you control gets +2/+2 until end of turn.
Whenever an opponent casts their second spell each turn, create a 2/2 green Wolf creature token.

Perplexing Chimera

Whenever an opponent casts a spell, you may exchange control of Perplexing Chimera and that spell. If you do, you may choose new targets for the spell. (If the spell becomes a permanent, you control that permanent.)

Yawgmoth's Edict

Whenever an opponent casts a white spell, that player loses 1 life and you gain 1 life.

Stomp

Damage can't be prevented this turn. Stomp deals 2 damage to any target.

Bonecrusher Giant

Whenever Bonecrusher Giant becomes the target of a spell, Bonecrusher Giant deals 2 damage to that spell's controller.

Bonecrusher Giant // Stomp

Sengir, the Dark Baron

Flying
Whenever another creature dies, put two +1/+1 counters on Sengir, the Dark Baron.
Whenever another player loses the game, you gain life equal to that player's life total as the turn began.
Partner (You can have two commanders if both have partner.)

Oath of Kaya

When Oath of Kaya enters the battlefield, it deals 3 damage to any target and you gain 3 life.
Whenever an opponent attacks a planeswalker you control with one or more creatures, Oath of Kaya deals 2 damage to that player and you gain 2 life.

Zurzoth, Chaos Rider

Whenever an opponent draws their first card each turn, if it's not their turn, you create a 1/1 red Devil creature token with "When this creature dies, it deals 1 damage to any target."
Whenever one or more Devils you control attack one or more players, you and those players each draw a card, then discard a card at random.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Predatory Hunger

Enchant creature
Whenever an opponent casts a creature spell, put a +1/+1 counter on enchanted creature.

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Thundering Mightmare

Soulbond (You may pair this creature with another unpaired creature when either enters the battlefield. They remain paired for as long as you control both of them.)
As long as Thundering Mightmare is paired with another creature, each of those creatures has "Whenever an opponent casts a spell, put a +1/+1 counter on this creature."