Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Séance

At the beginning of each upkeep, you may exile target creature card from your graveyard. If you do, create a token that's a copy of that card, except it's a Spirit in addition to its other types. Exile it at the beginning of the next end step.

Sedgemoor Witch

Menace
Ward—Pay 3 life. (Whenever this creature becomes the target of a spell or ability an opponent controls, counter it unless that player pays 3 life.)
Magecraft — Whenever you cast or copy an instant or sorcery spell, create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Pontiff of Blight

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Other creatures you control have extort. (If a creature has multiple instances of extort, each triggers separately.)

Bruna, the Fading Light

When you cast this spell, you may return target Angel or Human creature card from your graveyard to the battlefield.
Flying, vigilance
(Melds with Gisela, the Broken Blade.)

Athreos, God of Passage

Indestructible
As long as your devotion to white and black is less than seven, Athreos isn't a creature.
Whenever another creature you own dies, return it to your hand unless target opponent pays 3 life.

Kor Cartographer

When Kor Cartographer enters, you may search your library for a Plains card, put it onto the battlefield tapped, then shuffle.

Hero's Downfall

Scheming Symmetry

Choose two target players. Each of them searches their library for a card, then shuffles and puts that card on top.

Cathars' Crusade

Whenever a creature you control enters, put a +1/+1 counter on each creature you control.

Luminarch Ascension

At the beginning of each opponent's end step, if you didn't lose life this turn, you may put a quest counter on Luminarch Ascension. (Damage causes loss of life.)
{1}{W}: Create a 4/4 white Angel creature token with flying. Activate only if Luminarch Ascension has four or more quest counters on it.

Sword of the Animist

Equipped creature gets +1/+1.
Whenever equipped creature attacks, you may search your library for a basic land card, put it onto the battlefield tapped, then shuffle.
Equip {2}

Elesh Norn, Grand Cenobite

Vigilance
Other creatures you control get +2/+2.
Creatures your opponents control get -2/-2.

Despark

Exile target permanent with mana value 4 or greater.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Solemn Recruit

Double strike
Revolt — At the beginning of your end step, if a permanent you controlled left the battlefield this turn, put a +1/+1 counter on Solemn Recruit.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Utter End

Silence

Your opponents can't cast spells this turn.

Whip of Erebos

Creatures you control have lifelink.
{2}{B}{B}, {T}: Return target creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step. If it would leave the battlefield, exile it instead of putting it anywhere else. Activate only as a sorcery.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Swamp

Oblivion Stone

{4}, {T}: Put a fate counter on target permanent.
{5}, {T}, Sacrifice Oblivion Stone: Destroy each nonland permanent without a fate counter on it, then remove all fate counters from all permanents.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Vraska's Contempt

Exile target creature or planeswalker. You gain 2 life.

Altar of Dementia

Sacrifice a creature: Target player mills cards equal to the sacrificed creature's power.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Ajani's Pridemate

Whenever you gain life, put a +1/+1 counter on this creature.

Sword of Hearth and Home

Equipped creature gets +2/+2 and has protection from green and from white.
Whenever equipped creature deals combat damage to a player, exile up to one target creature you own, then search your library for a basic land card. Put both cards onto the battlefield under your control, then shuffle.
Equip {2}

Entreat the Dead

Return X target creature cards from your graveyard to the battlefield.
Miracle {X}{B}{B} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Suture Priest

Whenever another creature you control enters, you may gain 1 life.
Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Ayli, Eternal Pilgrim

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
{1}, Sacrifice another creature: You gain life equal to the sacrificed creature's toughness.
{1}{W}{B}, Sacrifice another creature: Exile target nonland permanent. Activate only if you have at least 10 life more than your starting life total.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Plains

Test of Endurance

At the beginning of your upkeep, if you have 50 or more life, you win the game.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Day of Judgment

Entomb

Search your library for a card, put that card into your graveyard, then shuffle.

Archangel of Thune

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Whenever you gain life, put a +1/+1 counter on each creature you control.

Balthor the Defiled

Minion creatures get +1/+1.
{B}{B}{B}, Exile Balthor the Defiled: Each player returns all black and all red creature cards from their graveyard to the battlefield.

Stoneforge Mystic

When Stoneforge Mystic enters, you may search your library for an Equipment card, reveal it, put it into your hand, then shuffle.
{1}{W}, {T}: You may put an Equipment card from your hand onto the battlefield.

Safe Passage

Prevent all damage that would be dealt to you and creatures you control this turn.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Mortify

Winds of Abandon

Exile target creature you don't control. For each creature exiled this way, its controller searches their library for a basic land card. Those players put those cards onto the battlefield tapped, then shuffle.
Overload {4}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Orzhov Signet

Entreat the Angels

Create X 4/4 white Angel creature tokens with flying.
Miracle {X}{W}{W} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Gisela, the Broken Blade

Flying, first strike, lifelink
At the beginning of your end step, if you both own and control Gisela, the Broken Blade and a creature named Bruna, the Fading Light, exile them, then meld them into Brisela, Voice of Nightmares.

Phyrexian Altar

Sacrifice a creature: Add one mana of any color.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Tragic Slip

Target creature gets -1/-1 until end of turn.
Morbid — That creature gets -13/-13 until end of turn instead if a creature died this turn.

Felidar Sovereign

Vigilance (Attacking doesn't cause this creature to tap.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your upkeep, if you have 40 or more life, you win the game.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Expedition Map

{2}, {T}, Sacrifice this artifact: Search your library for a land card, reveal it, put it into your hand, then shuffle.

Karlov of the Ghost Council

Whenever you gain life, put two +1/+1 counters on Karlov of the Ghost Council.
{W}{B}, Remove six +1/+1 counters from Karlov of the Ghost Council: Exile target creature.

Grave Betrayal

Whenever a creature you don't control dies, return it to the battlefield under your control with an additional +1/+1 counter on it at the beginning of the next end step. That creature is a black Zombie in addition to its other colors and types.

Vedalken Orrery

You may cast spells as though they had flash.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Go for the Throat

Remembrance

Whenever a nontoken creature you control dies, you may search your library for a card with the same name as that creature, reveal it, put it into your hand, then shuffle.

Reya Dawnbringer

Flying
At the beginning of your upkeep, you may return target creature card from your graveyard to the battlefield.

Sol Ring

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}