Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Dictate of the Twin Gods

Flash
If a source would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis, Unshackled.

Chaos Warp

The owner of target permanent shuffles it into their library, then reveals the top card of their library. If it's a permanent card, they put it onto the battlefield.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Pestilence

At the beginning of the end step, if no creatures are on the battlefield, sacrifice Pestilence.
{B}: Pestilence deals 1 damage to each creature and each player.

Thoughts of Ruin

Each player sacrifices a land for each card in your hand.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Rakdos Cluestone

{T}: Add {B} or {R}.
{B}{R}, {T}, Sacrifice Rakdos Cluestone: Draw a card.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Marchesa's Decree

When Marchesa's Decree enters, you become the monarch.
Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.

Angrath's Marauders

If a source you control would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Hissing Miasma

Whenever a creature attacks you, its controller loses 1 life.

Forced Fruition

Whenever an opponent casts a spell, that player draws seven cards.

Crawlspace

No more than two creatures can attack you each combat.

Repercussion

Whenever a creature is dealt damage, Repercussion deals that much damage to that creature's controller.

Crimson Honor Guard

Trample
At the beginning of each player's end step, Crimson Honor Guard deals 4 damage to that player unless they control a commander.

Memory Erosion

Whenever an opponent casts a spell, that player mills two cards.

Khorvath's Fury

For each player, choose friend or foe. Each friend discards all cards from their hand, then draws that many cards plus one. Khorvath's Fury deals damage to each foe equal to the number of cards in their hand.

Flame Rift

Flame Rift deals 4 damage to each player.

Geth, Lord of the Vault

Intimidate (This creature can't be blocked except by artifact creatures and/or creatures that share a color with it.)
{X}{B}: Put target artifact or creature card with mana value X from an opponent's graveyard onto the battlefield under your control tapped. Then that player mills X cards.

Ankh of Mishra

Whenever a land enters, Ankh of Mishra deals 2 damage to that land's controller.

Bloodstone Cameo

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Citadel of Pain

At the beginning of each player's end step, Citadel of Pain deals X damage to that player, where X is the number of untapped lands they control.

Sin Prodder

Menace
At the beginning of your upkeep, reveal the top card of your library. Any opponent may have you put that card into your graveyard. If a player does, Sin Prodder deals damage to that player equal to that card's mana value. Otherwise, put that card into your hand.

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Sulfuric Vortex

At the beginning of each player's upkeep, Sulfuric Vortex deals 2 damage to that player.
If a player would gain life, that player gains no life instead.

Guiltfeeder

Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
Whenever Guiltfeeder attacks and isn't blocked, defending player loses 1 life for each card in their graveyard.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Sire of Insanity

At the beginning of each end step, each player discards their hand.

Fanatic of Mogis

When Fanatic of Mogis enters, it deals damage to each opponent equal to your devotion to red. (Each {R} in the mana costs of permanents you control counts toward your devotion to red.)

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Wrexial, the Risen Deep

Islandwalk, swampwalk (This creature can't be blocked as long as defending player controls an Island or a Swamp.)
Whenever Wrexial, the Risen Deep deals combat damage to a player, you may cast target instant or sorcery card from that player's graveyard without paying its mana cost. If that spell would be put into a graveyard, exile it instead.

Davriel, Rogue Shadowmage

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, Davriel, Rogue Shadowmage deals 2 damage to them.
−1: Target player discards a card.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Clear the Mind

Target player shuffles their graveyard into their library.
Draw a card.

Fraying Omnipotence

Each player loses half their life, then discards half the cards in their hand, then sacrifices half the creatures they control. Round up each time.

Kozilek, Butcher of Truth

When you cast this spell, draw four cards.
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents.)
When Kozilek, Butcher of Truth is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.

Murder

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Burnished Hart

{3}, Sacrifice Burnished Hart: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control, then sacrifices a third of the lands they control. Round up each time.

Last One Standing

Choose a creature at random, then destroy the rest.

Merciless Executioner

When Merciless Executioner enters, each player sacrifices a creature.

Bloodghast

Bloodghast can't block.
Bloodghast has haste as long as an opponent has 10 or less life.
Landfall — Whenever a land you control enters, you may return Bloodghast from your graveyard to the battlefield.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Rampaging Ferocidon

Menace
Players can't gain life.
Whenever another creature enters, Rampaging Ferocidon deals 1 damage to that creature's controller.

Spellshock

Whenever a player casts a spell, Spellshock deals 2 damage to that player.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Plague Spitter

At the beginning of your upkeep, Plague Spitter deals 1 damage to each creature and each player.
When Plague Spitter dies, it deals 1 damage to each creature and each player.

Finale of Revelation

Draw X cards. If X is 10 or more, instead shuffle your graveyard into your library, draw X cards, untap up to five lands, and you have no maximum hand size for the rest of the game.
Exile Finale of Revelation.

Zo-Zu the Punisher

Whenever a land enters, Zo-Zu the Punisher deals 2 damage to that land's controller.

Curse of the Pierced Heart

Enchant player
At the beginning of enchanted player's upkeep, Curse of the Pierced Heart deals 1 damage to that player or a planeswalker that player controls.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Torment of Scarabs

Enchant player
At the beginning of enchanted player's upkeep, that player loses 3 life unless they sacrifice a nonland permanent or discard a card.

Harsh Mentor

Whenever an opponent activates an ability of an artifact, creature, or land on the battlefield, if it isn't a mana ability, Harsh Mentor deals 2 damage to that player.

Go for the Throat

Rakdos Charm

Choose one —
• Exile target player's graveyard.
• Destroy target artifact.
• Each creature deals 1 damage to its controller.

Rakdos Locket

{T}: Add {B} or {R}.
{B/R}{B/R}{B/R}{B/R}, {T}, Sacrifice Rakdos Locket: Draw two cards.

Jeleva, Nephalia's Scourge

Flying
When Jeleva, Nephalia's Scourge enters, each player exiles the top X cards of their library, where X is the amount of mana spent to cast Jeleva.
Whenever Jeleva attacks, you may cast an instant or sorcery spell from among cards exiled with Jeleva without paying its mana cost.

Blightning

Blightning deals 3 damage to target player or planeswalker. That player or that planeswalker's controller discards two cards.

Rain of Gore

If a spell or ability would cause its controller to gain life, that player loses that much life instead.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Dreadbore

Doom Blade

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature, then sacrifices a land.

Archfiend of Depravity

Flying
At the beginning of each opponent's end step, that player chooses up to two creatures they control, then sacrifices the rest.

Decree of Annihilation

Exile all artifacts, creatures, and lands from the battlefield, all cards from all graveyards, and all cards from all hands.
Cycling {5}{R}{R} ({5}{R}{R}, Discard this card: Draw a card.)
When you cycle Decree of Annihilation, destroy all lands.

Unlicensed Disintegration

Destroy target creature. If you control an artifact, Unlicensed Disintegration deals 3 damage to that creature's controller.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Tainted Aether

Whenever a creature enters, its controller sacrifices a creature or land.

Darksteel Ingot

Indestructible (Effects that say "destroy" don't destroy this artifact.)
{T}: Add one mana of any color.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Barbed Wire

At the beginning of each player's upkeep, Barbed Wire deals 1 damage to that player.
{2}: Prevent the next 1 damage that would be dealt by Barbed Wire this turn.

Mindmoil

Whenever you cast a spell, put the cards in your hand on the bottom of your library in any order, then draw that many cards.

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Indulgent Tormentor

Flying
At the beginning of your upkeep, draw a card unless target opponent sacrifices a creature or pays 3 life.

Fleshbag Marauder

When Fleshbag Marauder enters, each player sacrifices a creature.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters, each player loses a third of their life, rounded up.

Ribbons

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Each opponent loses X life.

Cut // Ribbons

Acidic Soil

Acidic Soil deals damage to each player equal to the number of lands they control.

Magus of the Wheel

{1}{R}, {T}, Sacrifice Magus of the Wheel: Each player discards their hand, then draws seven cards.

Grim Guardian

Constellation — Whenever Grim Guardian or another enchantment you control enters, each opponent loses 1 life.

Aurora of Emrakul

Flying, deathtouch
Whenever Aurora of Emrakul attacks, each opponent loses 3 life.

Cryptolith Fragment

Cryptolith Fragment enters tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform Cryptolith Fragment.

Cryptolith Fragment // Aurora of Emrakul

Terminate

Destroy target creature. It can't be regenerated.

Bend or Break

Each player separates all nontoken lands they control into two piles. For each player, one of their piles is chosen by one of their opponents of their choice. Destroy all lands in the chosen piles. Tap all lands in the other piles.

Manabarbs

Whenever a player taps a land for mana, Manabarbs deals 1 damage to that player.

Oppression

Whenever a player casts a spell, that player discards a card.

Witch Hunt

Players can't gain life.
At the beginning of your upkeep, Witch Hunt deals 4 damage to you.
At the beginning of your end step, target opponent chosen at random gains control of Witch Hunt.

Furnace of Rath

If a source would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Mind Grind

Each opponent reveals cards from the top of their library until they reveal X land cards, then puts all cards revealed this way into their graveyard. X can't be 0.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Jace's Archivist

{U}, {T}: Each player discards their hand, then draws cards equal to the greatest number of cards a player discarded this way.

Dingus Staff

Whenever a creature dies, Dingus Staff deals 2 damage to that creature's controller.

Blood Reckoning

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.