Yawgmoth, Thran Physician

Protection from Humans
Pay 1 life, Sacrifice another creature: Put a -1/-1 counter on up to one target creature and draw a card.
{B}{B}, Discard a card: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Devoted Druid

{T}: Add {G}.
Put a -1/-1 counter on this creature: Untap this creature.

Obelisk Spider

Reach
Whenever this creature deals combat damage to a creature, put a -1/-1 counter on that creature.
Whenever you put one or more -1/-1 counters on a creature, each opponent loses 1 life and you gain 1 life.

Everlasting Torment

Players can't gain life.
Damage can't be prevented.
All damage is dealt as though its source had wither. (A source with wither deals damage to creatures in the form of -1/-1 counters.)

Nest of Scarabs

Whenever you put one or more -1/-1 counters on a creature, create that many 1/1 black Insect creature tokens.

Murderous Redcap

When this creature enters, it deals damage equal to its power to any target.
Persist (When this creature dies, if it had no -1/-1 counters on it, return it to the battlefield under its owner's control with a -1/-1 counter on it.)

Grumgully, the Generous

Each other non-Human creature you control enters with an additional +1/+1 counter on it.

Hapatra, Vizier of Poisons

Whenever Hapatra deals combat damage to a player, you may put a -1/-1 counter on target creature.
Whenever you put one or more -1/-1 counters on a creature, create a 1/1 green Snake creature token with deathtouch.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with this creature's toughness.

The Reaper, King No More

When The Reaper enters, put a -1/-1 counter on each of up to two target creatures.
Whenever a creature an opponent controls with a -1/-1 counter on it dies, you may put that card onto the battlefield under your control. Do this only once each turn.

Blood Artist

Whenever this creature or another creature dies, target player loses 1 life and you gain 1 life.

Mikaeus, the Unhallowed

Intimidate (This creature can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever a Human deals damage to you, destroy it.
Other non-Human creatures you control get +1/+1 and have undying. (When a creature with undying dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

All Will Be One

Whenever you put one or more counters on a permanent or player, this enchantment deals that much damage to target opponent, creature an opponent controls, or planeswalker an opponent controls.

Blowfly Infestation

Whenever a creature dies, if it had a -1/-1 counter on it, put a -1/-1 counter on target creature.

Zulaport Cutthroat

Whenever this creature or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Auntie Ool, Cursewretch

Ward—Blight 2. (To blight 2, a player puts two -1/-1 counters on a creature they control.)
Whenever one or more -1/-1 counters are put on a creature, draw a card if you control that creature. If you don't control it, its controller loses 1 life.

Goblin Bombardment

Sacrifice a creature: This enchantment deals 1 damage to any target.

Quillspike

{B/G}, Remove a -1/-1 counter from a creature you control: This creature gets +3/+3 until end of turn.

Flourishing Defenses

Whenever a -1/-1 counter is put on a creature, you may create a 1/1 green Elf Warrior creature token.

Dread Tiller

When this creature enters, put a -1/-1 counter on target creature.
Whenever a creature with a -1/-1 counter on it dies, you may put a land card from your hand or graveyard onto the battlefield tapped.

Soul Immolation

As an additional cost to cast this spell, blight X. X can't be greater than the greatest toughness among creatures you control. (Put X -1/-1 counters on a creature you control.)
Soul Immolation deals X damage to each opponent and each creature they control.