Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• This creature deals 2 damage to any target and you gain 2 life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Armaggon, Future Shark

Flash
When Armaggon enters, destroy up to three target creatures.

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Darkness

Prevent all combat damage that would be dealt this turn.

Go for the Throat

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Massacre Wurm

When this creature enters, creatures your opponents control get -2/-2 until end of turn.
Whenever a creature an opponent controls dies, that player loses 2 life.

Bloodthirsty Conqueror

Flying, deathtouch
Whenever an opponent loses life, you gain that much life. (Damage causes loss of life.)

The Darkness Crystal

Black spells you cast cost {1} less to cast.
If a nontoken creature an opponent controls would die, instead exile it and you gain 2 life.
{4}{B}{B}, {T}: Put target creature card exiled with The Darkness Crystal onto the battlefield tapped under your control with two additional +1/+1 counters on it.

Mai, Scornful Striker

First strike
Whenever a player casts a noncreature spell, they lose 2 life.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Scrawling Crawler

At the beginning of your upkeep, each player draws a card.
Whenever an opponent draws a card, that player loses 1 life.

Ankh of Mishra

Whenever a land enters, this artifact deals 2 damage to that land's controller.

Staff of the Death Magus

Whenever you cast a black spell or a Swamp you control enters, you gain 1 life.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Soot Imp

Flying
Whenever a player casts a nonblack spell, that player loses 1 life.

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Dark Ritual

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Creeping Bloodsucker

At the beginning of your upkeep, this creature deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Fate Unraveler

Whenever an opponent draws a card, this creature deals 1 damage to that player.

Infernal Grasp

Destroy target creature. You lose 2 life.

Withering Torment

Destroy target creature or enchantment. You lose 2 life.

Charcoal Diamond

This artifact enters tapped.
{T}: Add {B}.

Imperial Seal

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to that card's mana value.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Gray Merchant of Asphodel

When this creature enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Blood Artist

Whenever this creature or another creature dies, target player loses 1 life and you gain 1 life.

Rug of Smothering

Flying
Whenever a player casts a spell, they lose 1 life for each spell they've cast this turn.

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Sol Ring

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Underworld Dreams

Whenever an opponent draws a card, this enchantment deals 1 damage to that player.