Let's Play a Game

Delirium — Choose one. If there are four or more card types among cards in your graveyard, choose one or more instead.
• Creatures your opponents control get -1/-1 until end of turn.
• Each opponent discards two cards.
• Each opponent loses 3 life and you gain 3 life.

Vampire Neonate

{2}, {T}: Each opponent loses 1 life and you gain 1 life.

Sinister Monolith

At the beginning of combat on your turn, each opponent loses 1 life and you gain 1 life.
{T}, Pay 2 life, Sacrifice this artifact: Draw two cards. Activate only as a sorcery.

Dimension X Pizzasaur

When this creature enters, put two +1/+1 counters on target creature. When you do, destroy up to one target creature with mana value less than or equal to the number of counters among permanents you control.
{2}, {T}, Sacrifice this creature: You gain 3 life and each opponent loses 3 life.

Zulaport Cutthroat

Whenever this creature or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Dream Beavers

Flying
When this creature enters, each opponent loses 1 life and you gain 1 life. Scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Sauron, the Lidless Eye

When Sauron enters, gain control of target creature an opponent controls until end of turn. Untap it. It gains haste until end of turn.
{1}{B}{R}: Creatures you control get +2/+0 until end of turn. Each opponent loses 2 life.

Drossclaw

Living weapon (When this Equipment enters, create a 0/0 black Phyrexian Germ creature token, then attach this to it.)
Equipped creature gets +1/+1.
Whenever equipped creature attacks, each opponent loses 1 life.
Equip {2}

Creeping Bloodsucker

At the beginning of your upkeep, this creature deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Within Range

When this enchantment enters, create two 1/1 red Warrior creature tokens.
Whenever you attack, each opponent loses life equal to the number of creatures attacking them.

Retreat to Hagra

Landfall — Whenever a land you control enters, choose one —
• Target creature gets +1/+0 and gains deathtouch until end of turn.
• Each opponent loses 1 life and you gain 1 life.

Solphim, Mayhem Dominus

If a source you control would deal noncombat damage to an opponent or a permanent an opponent controls, it deals double that damage to that player or permanent instead.
{1}{R/P}{R/P}, Discard two cards: Put an indestructible counter on Solphim. ({R/P} can be paid with either {R} or 2 life.)

Grave Endeavor

Roll two d10 and choose one result. Return a creature card from your graveyard to the battlefield with a number of +1/+1 counters on it equal to that result. Then each opponent loses X life and you gain X life, where X is the other result.

Gev, Scaled Scorch

Ward—Pay 2 life.
Other creatures you control enter with an additional +1/+1 counter on them for each opponent who lost life this turn.
Whenever you cast a Lizard spell, Gev deals 1 damage to target opponent.

Kalastria Healer

Rally — Whenever this creature or another Ally you control enters, each opponent loses 1 life and you gain 1 life.

Underhanded Designs

Whenever an artifact you control enters, you may pay {1}. If you do, each opponent loses 1 life and you gain 1 life.
{1}{B}, Sacrifice this enchantment: Destroy target creature. Activate only if you control two or more artifacts.

Night Market Lookout

Whenever this creature becomes tapped, each opponent loses 1 life and you gain 1 life.

Aurora of Emrakul

Flying, deathtouch
Whenever this creature attacks, each opponent loses 3 life.

Cryptolith Fragment

This artifact enters tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform this artifact.

Cryptolith Fragment // Aurora of Emrakul

Mardu Shadowspear

Whenever this creature attacks, each opponent loses 1 life.
Dash {1}{B} (You may cast this spell for its dash cost. If you do, it gains haste, and it's returned from the battlefield to its owner's hand at the beginning of the next end step.)

Pactdoll Terror

Whenever this creature or another artifact you control enters, each opponent loses 1 life and you gain 1 life.

Kardur, Doomscourge

When Kardur enters, until your next turn, creatures your opponents control attack each combat if able and attack a player other than you if able.
Whenever an attacking creature dies, each opponent loses 1 life and you gain 1 life.

Cauldron Familiar

When this creature enters, each opponent loses 1 life and you gain 1 life.
Sacrifice a Food: Return this card from your graveyard to the battlefield.

Agate Instigator

Offspring {1}{R} (You may pay an additional {1}{R} as you cast this spell. If you do, when this creature enters, create a 1/1 token copy of it.)
Whenever another creature you control enters, this creature deals 1 damage to each opponent.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Valgavoth, Harrower of Souls

Flying
Ward—Pay 2 life.
Whenever an opponent loses life for the first time during each of their turns, put a +1/+1 counter on Valgavoth and draw a card.

Siege Zombie

Tap three untapped creatures you control: Each opponent loses 1 life.

Temple of Power

(Transforms from Ojer Axonil, Deepest Might.)
{T}: Add {R}.
{2}{R}, {T}: Transform this land. Activate only if red sources you controlled dealt 4 or more noncombat damage this turn and only as a sorcery.

Ojer Axonil, Deepest Might

Trample
If a red source you control would deal an amount of noncombat damage less than Ojer Axonil's power to an opponent, that source deals damage equal to Ojer Axonil's power instead.
When Ojer Axonil dies, return it to the battlefield tapped and transformed under its owner's control.

Ojer Axonil, Deepest Might // Temple of Power

Vicious Conquistador

Whenever this creature attacks, each opponent loses 1 life.

Delta Bloodflies

Flying
Whenever this creature attacks, if you control a creature with a counter on it, each opponent loses 1 life.

Tenured Inkcaster

When this creature enters, put a +1/+1 counter on target creature.
Whenever a creature you control with a +1/+1 counter on it attacks, each opponent loses 1 life and you gain 1 life.

Sanguine Syphoner

Whenever this creature attacks, each opponent loses 1 life and you gain 1 life.

Leechridden Swamp

({T}: Add {B}.)
This land enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Subversion

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Pulse Tracker

Herald of Hadar

Circle of Death — {5}{B}: Roll a d20.
1—9 | Each opponent loses 2 life.
10—19 | Each opponent loses 2 life and you gain 2 life.
20 | Each opponent loses 2 life and you gain 2 life. Create two Treasure tokens. (They're artifacts with "{T}, Sacrifice this token: Add one mana of any color.")

Sanctum Seeker

Whenever a Vampire you control attacks, each opponent loses 1 life and you gain 1 life.

Ob Nixilis of the Black Oath

+2: Each opponent loses 1 life. You gain life equal to the life lost this way.
−2: Create a 5/5 black Demon creature token with flying. You lose 2 life.
−8: You get an emblem with "{1}{B}, Sacrifice a creature: You gain X life and draw X cards, where X is the sacrificed creature's power."
Ob Nixilis of the Black Oath can be your commander.

Grim Guardian

Constellation — Whenever this creature or another enchantment you control enters, each opponent loses 1 life.

Nezumi Road Captain

Menace
Vehicles you control have menace. (They can't be blocked except by two or more creatures.)

Okiba Reckoner Raid

(As this Saga enters and after your draw step, add a lore counter.)
I, II — Each opponent loses 1 life and you gain 1 life.
III — Exile this Saga, then return it to the battlefield transformed under your control.

Okiba Reckoner Raid // Nezumi Road Captain

Raven of Fell Omens

Flying
Whenever you commit a crime, each opponent loses 1 life and you gain 1 life. This ability triggers only once each turn. (Targeting opponents, anything they control, and/or cards in their graveyards is a crime.)

Servant of Tymaret

Inspired — Whenever this creature becomes untapped, each opponent loses 1 life. You gain life equal to the life lost this way.
{2}{B}: Regenerate this creature.

Agate-Blade Assassin

Whenever this creature attacks, defending player loses 1 life and you gain 1 life.

Venerated Stormsinger

Mobilize 1 (Whenever this creature attacks, create a tapped and attacking 1/1 red Warrior creature token. Sacrifice it at the beginning of the next end step.)
Whenever this creature or another creature you control dies, each opponent loses 1 life and you gain 1 life.