Sphere of Annihilation

Sphere of Annihilation enters with X void counters on it.
At the beginning of your upkeep, exile Sphere of Annihilation, all creatures and planeswalkers with mana value less than or equal to the number of void counters on it, and all creature and planeswalker cards in graveyards with mana value less than or equal to the number of void counters on it.

Urza's Saga

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Urza's Saga gains "{T}: Add {C}."
II — Urza's Saga gains "{2}, {T}: Create a 0/0 colorless Construct artifact creature token with 'This creature gets +1/+1 for each artifact you control.'"
III — Search your library for an artifact card with mana cost {0} or {1}, put it onto the battlefield, then shuffle.

Defense Grid

Each spell costs {3} more to cast except during its controller's turn.

Walking Ballista

Walking Ballista enters with X +1/+1 counters on it.
{4}: Put a +1/+1 counter on Walking Ballista.
Remove a +1/+1 counter from Walking Ballista: It deals 1 damage to any target.

Karn, Scion of Urza

+1: Reveal the top two cards of your library. An opponent chooses one of them. Put that card into your hand and exile the other with a silver counter on it.
−1: Put a card you own with a silver counter on it from exile into your hand.
−2: Create a 0/0 colorless Construct artifact creature token with "This creature gets +1/+1 for each artifact you control."

Blast Zone

Blast Zone enters with a charge counter on it.
{T}: Add {C}.
{X}{X}, {T}: Put X charge counters on Blast Zone.
{3}, {T}, Sacrifice Blast Zone: Destroy each nonland permanent with mana value equal to the number of charge counters on Blast Zone.

The Underworld Cookbook

{T}, Discard a card: Create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")
{4}, {T}, Sacrifice The Underworld Cookbook: Return target creature card from your graveyard to your hand.

Maralen of the Mornsong

Players can't draw cards.
At the beginning of each player's draw step, that player loses 3 life, searches their library for a card, puts it into their hand, then shuffles.

Inventors' Fair

At the beginning of your upkeep, if you control three or more artifacts, you gain 1 life.
{T}: Add {C}.
{4}, {T}, Sacrifice Inventors' Fair: Search your library for an artifact card, reveal it, put it into your hand, then shuffle. Activate only if you control three or more artifacts.

Plague Engineer

Deathtouch
As Plague Engineer enters, choose a creature type.
Creatures of the chosen type your opponents control get -1/-1.

Liquimetal Coating

{T}: Target permanent becomes an artifact in addition to its other types until end of turn.

Ancient Tomb

{T}: Add {C}{C}. Ancient Tomb deals 2 damage to you.

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Mox Diamond

If Mox Diamond would enter, you may discard a land card instead. If you do, put Mox Diamond onto the battlefield. If you don't, put it into its owner's graveyard.
{T}: Add one mana of any color.

Swamp

Expedition Map

{2}, {T}, Sacrifice this artifact: Search your library for a land card, reveal it, put it into your hand, then shuffle.

Dark Ritual

Karakas

{T}: Add {W}.
{T}: Return target legendary creature to its owner's hand.

The Meathook Massacre

When The Meathook Massacre enters, each creature gets -X/-X until end of turn.
Whenever a creature you control dies, each opponent loses 1 life.
Whenever a creature an opponent controls dies, you gain 1 life.

Sudden Edict

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Target player sacrifices a creature of their choice.

To the Slaughter

Target player sacrifices a creature or planeswalker of their choice.
Delirium — If there are four or more card types among cards in your graveyard, instead that player sacrifices a creature and a planeswalker of their choice.

Pithing Needle

As Pithing Needle enters, choose a card name.
Activated abilities of sources with the chosen name can't be activated unless they're mana abilities.

Retrofitter Foundry

{3}: Untap Retrofitter Foundry.
{2}, {T}: Create a 1/1 colorless Servo artifact creature token.
{1}, {T}, Sacrifice a Servo: Create a 1/1 colorless Thopter artifact creature token with flying.
{T}, Sacrifice a Thopter: Create a 4/4 colorless Construct artifact creature token.

Shadowspear

Equipped creature gets +1/+1 and has trample and lifelink.
{1}: Permanents your opponents control lose hexproof and indestructible until end of turn.
Equip {2}

Ifnir Deadlands

{T}: Add {C}.
{T}, Pay 1 life: Add {B}.
{2}{B}{B}, {T}, Sacrifice a Desert: Put two -1/-1 counters on target creature an opponent controls. Activate only as a sorcery.

Helm of Obedience

{X}, {T}: Target opponent mills a card, then repeats this process until a creature card or X cards have been put into their graveyard this way, whichever comes first. If one or more creature cards were put into that graveyard this way, sacrifice Helm of Obedience and put one of them onto the battlefield under your control. X can't be 0.

Ensnaring Bridge

Creatures with power greater than the number of cards in your hand can't attack.

Karn, the Great Creator

Activated abilities of artifacts your opponents control can't be activated.
+1: Until your next turn, up to one target noncreature artifact becomes an artifact creature with power and toughness each equal to its mana value.
−2: You may reveal an artifact card you own from outside the game or choose a face-up artifact card you own in exile. Put that card into your hand.

Crucible of Worlds

Dauthi Voidwalker

Shadow (This creature can block or be blocked by only creatures with shadow.)
If a card would be put into an opponent's graveyard from anywhere, instead exile it with a void counter on it.
{T}, Sacrifice Dauthi Voidwalker: Choose an exiled card an opponent owns with a void counter on it. You may play it this turn without paying its mana cost.

Mycosynth Lattice

All permanents are artifacts in addition to their other types.
All cards that aren't on the battlefield, spells, and permanents are colorless.
Players may spend mana as though it were mana of any color.

City of Traitors

When you play another land, sacrifice City of Traitors.
{T}: Add {C}{C}.

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice Silent Clearing: Draw a card.

Leyline of the Void

If Leyline of the Void is in your opening hand, you may begin the game with it on the battlefield.
If a card would be put into an opponent's graveyard from anywhere, exile it instead.

Serum Powder

{T}: Add {C}.
Any time you could mulligan and Serum Powder is in your hand, you may exile all the cards from your hand, then draw that many cards. (You can do this in addition to taking mulligans.)