Sign in Blood

Target player draws two cards and loses 2 life.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Scoured Barrens

Scoured Barrens enters the battlefield tapped.
When Scoured Barrens enters the battlefield, you gain 1 life.
{T}: Add {W} or {B}.

Vampire Scrivener

Flying
Whenever you gain life during your turn, put a +1/+1 counter on Vampire Scrivener.
Whenever you lose life during your turn, put a +1/+1 counter on Vampire Scrivener.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Blood Pact

Suffer the Past

Exile X target cards from target player's graveyard. For each card exiled this way, that player loses 1 life and you gain 1 life.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Creeping Bloodsucker

At the beginning of your upkeep, Creeping Bloodsucker deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Hierophant's Chalice

When Hierophant's Chalice enters the battlefield, target opponent loses 1 life and you gain 1 life.
{T}: Add {C}.

Soul Feast

Target player loses 4 life and you gain 4 life.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Scourge of the Skyclaves

Kicker {4}{B}
When you cast this spell, if it was kicked, each player loses half their life, rounded up.
Scourge of the Skyclaves's power and toughness are each equal to 20 minus the highest life total among players.

Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.

Indulging Patrician

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your end step, if you gained 3 or more life this turn, each opponent loses 3 life.

Swamp

Caress of Phyrexia

Target player draws three cards, loses 3 life, and gets three poison counters.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Kaya, Intangible Slayer

Hexproof
+2: Each opponent loses 3 life and you gain 3 life.
0: You draw two cards. Then each opponent may scry 1.
−3: Exile target creature or enchantment. If it wasn't an Aura, create a token that's a copy of it, except it's a 1/1 white Spirit creature with flying in addition to its other types.

Diregraf Scavenger

Deathtouch
When Diregraf Scavenger enters the battlefield, exile up to one target card from a graveyard. If a creature card was exiled this way, each opponent loses 2 life and you gain 2 life.

Agent of Masks

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Shard of the Nightbringer

Flying
Drain Life — When Shard of the Nightbringer enters the battlefield, if you cast it, target opponent loses half their life, rounded up. You gain life equal to the life lost this way.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Temple of Silence

Temple of Silence enters the battlefield tapped.
When Temple of Silence enters the battlefield, scry 1.
{T}: Add {W} or {B}.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Fraying Omnipotence

Each player loses half their life, then discards half the cards in their hand, then sacrifices half the creatures they control. Round up each time.

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Blitzwing, Adaptive Assailant

Living metal (As long as it's your turn, this Vehicle is also a creature.)
At the beginning of combat on your turn, choose flying or indestructible at random. Blitzwing gains that ability until end of turn.
Whenever Blitzwing deals combat damage to a player, convert it.

Blitzwing, Cruel Tormentor

More Than Meets the Eye {3}{B} (You may cast this card converted for {3}{B}.)
At the beginning of your end step, target opponent loses life equal to the life that player lost this turn. If no life is lost this way, convert Blitzwing.

Blitzwing, Cruel Tormentor // Blitzwing, Adaptive Assailant

Plains

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Subversion

Sovereign's Bite

Target player loses 3 life and you gain 3 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Evolving Wilds

{T}, Sacrifice Evolving Wilds: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Loyal Subordinate

Menace
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Damnable Pact

Target player draws X cards and loses X life.

Kaya, Ghost Assassin

0: Exile Kaya, Ghost Assassin or up to one target creature. Return that card to the battlefield under its owner's control at the beginning of your next upkeep. You lose 2 life.
−1: Each opponent loses 2 life and you gain 2 life.
−2: Each opponent discards a card and you draw a card.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Palace Siege

As Palace Siege enters the battlefield, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Wedding Ring

When Wedding Ring enters the battlefield, if it was cast, target opponent creates a token that's a copy of it.
Whenever an opponent who controls an artifact named Wedding Ring draws a card during their turn, you draw a card.
Whenever an opponent who controls an artifact named Wedding Ring gains life during their turn, you gain that much life.

Final Punishment

Target player loses life equal to the damage already dealt to that player this turn.

Fetid Heath

{T}: Add {C}.
{W/B}, {T}: Add {W}{W}, {W}{B}, or {B}{B}.

Shattered Sanctum

Shattered Sanctum enters the battlefield tapped unless you control two or more other lands.
{T}: Add {W} or {B}.

Bellowing Mauler

At the beginning of your end step, each player loses 4 life unless they sacrifice a nontoken creature.

Court of Ambition

When Court of Ambition enters the battlefield, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Foul-Tongue Shriek

Target opponent loses 1 life for each attacking creature you control. You gain that much life.

Greed

Vampire Spawn

When Vampire Spawn enters the battlefield, each opponent loses 2 life and you gain 2 life.

Astarion's Thirst

Exile target creature. Put X +1/+1 counters on a commander creature you control, where X is the power of the creature exiled this way.

Vampire Sovereign

Flying
When Vampire Sovereign enters the battlefield, target opponent loses 3 life and you gain 3 life.

Command Tower

Batwing Brume

Prevent all combat damage that would be dealt this turn if {W} was spent to cast this spell. Each player loses 1 life for each attacking creature they control if {B} was spent to cast this spell. (Do both if {W}{B} was spent.)

Vampire's Kiss

Target player loses 2 life and you gain 2 life. Create two Blood tokens. (They're artifacts with "{1}, {T}, Discard a card, Sacrifice this artifact: Draw a card.")

Soul Warden

Whenever another creature enters the battlefield, you gain 1 life.

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform Chalice of Life.

Chalice of Life // Chalice of Death

Soul's Attendant

Whenever another creature enters the battlefield, you may gain 1 life.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Pact of the Serpent

Choose a creature type. Target player draws X cards and loses X life, where X is the number of creatures they control of the chosen type.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters the battlefield, each player loses a third of their life, rounded up.

Orzhov Basilica

Orzhov Basilica enters the battlefield tapped.
When Orzhov Basilica enters the battlefield, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Absorb Vis

Target player loses 4 life and you gain 4 life.
Basic landcycling {1}{B} ({1}{B}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Blood Tribute

Kicker—Tap an untapped Vampire you control. (You may tap a Vampire you control in addition to any other costs as you cast this spell.)
Target opponent loses half their life, rounded up. If this spell was kicked, you gain life equal to the life lost this way.

Isolated Chapel

Isolated Chapel enters the battlefield tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Astarion, the Decadent

Deathtouch, lifelink
At the beginning of your end step, choose one —
• Feed — Target opponent loses life equal to the amount of life they lost this turn.
• Friends — You gain life equal to the amount of life you gained this turn.

Zof Bloodbog

Zof Bloodbog enters the battlefield tapped.
{T}: Add {B}.

Zof Consumption

Each opponent loses 4 life and you gain 4 life.

Zof Consumption // Zof Bloodbog

Syphon Soul

Syphon Soul deals 2 damage to each other player. You gain life equal to the damage dealt this way.

Sol Ring

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Arrogant Outlaw

When Arrogant Outlaw enters the battlefield, if an opponent lost life this turn, each opponent loses 2 life and you gain 2 life.

Shineshadow Snarl

As Shineshadow Snarl enters the battlefield, you may reveal a Plains or Swamp card from your hand. If you don't, Shineshadow Snarl enters the battlefield tapped.
{T}: Add {W} or {B}.

Ill-Gotten Inheritance

At the beginning of your upkeep, Ill-Gotten Inheritance deals 1 damage to each opponent and you gain 1 life.
{5}{B}, Sacrifice Ill-Gotten Inheritance: It deals 4 damage to target opponent and you gain 4 life.

Vault of Champions

Vault of Champions enters the battlefield tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Profane Command

Choose two —
• Target player loses X life.
• Return target creature card with mana value X or less from your graveyard to the battlefield.
• Target creature gets -X/-X until end of turn.
• Up to X target creatures gain fear until end of turn. (They can't be blocked except by artifact creatures and/or black creatures.)

Cruel Celebrant

Whenever Cruel Celebrant or another creature or planeswalker you control dies, each opponent loses 1 life and you gain 1 life.

Life Insurance

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever a nontoken creature dies, you lose 1 life and create a Treasure token.

Alms of the Vein

Target opponent loses 3 life and you gain 3 life.
Madness {B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Phthisis

Destroy target creature. Its controller loses life equal to its power plus its toughness.
Suspend 5—{1}{B} (Rather than cast this card from your hand, you may pay {1}{B} and exile it with five time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)