Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Gonti's Machinations

Whenever you lose life for the first time each turn, you get {E}. (You get an energy counter. Damage causes loss of life.)
Pay {E}{E}, Sacrifice this enchantment: Each opponent loses 3 life. You gain life equal to the life lost this way.

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Sever Soul

Destroy target nonblack creature. It can't be regenerated. You gain life equal to its toughness.

Grave Endeavor

Roll two d10 and choose one result. Return a creature card from your graveyard to the battlefield with a number of +1/+1 counters on it equal to that result. Then each opponent loses X life and you gain X life, where X is the other result.

Scourge of the Skyclaves

Kicker {4}{B}
When you cast this spell, if it was kicked, each player loses half their life, rounded up.
Scourge of the Skyclaves's power and toughness are each equal to 20 minus the highest life total among players.

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Shriveling Rot

Choose one —
• Until end of turn, whenever a creature is dealt damage, destroy it.
• Until end of turn, whenever a creature dies, that creature's controller loses life equal to its toughness.
Entwine {2}{B} (Choose both if you pay the entwine cost.)

Laquatus's Champion

When this creature enters, target player loses 6 life.
When this creature leaves the battlefield, that player gains 6 life.
{B}: Regenerate this creature.