Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Scytheclaw

Living weapon (When this Equipment enters, create a 0/0 black Phyrexian Germ creature token, then attach this to it.)
Equipped creature gets +1/+1.
Whenever equipped creature deals combat damage to a player, that player loses half their life, rounded up.
Equip {3}

Sign in Blood

Target player draws two cards and loses 2 life.

Orzhov Advokist

At the beginning of your upkeep, each player may put two +1/+1 counters on a creature they control. If a player does, creatures that player controls can't attack you or planeswalkers you control until your next turn.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Orzhov Basilica

Orzhov Basilica enters tapped.
When Orzhov Basilica enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Plains

Key to the City

{T}, Discard a card: Up to one target creature can't be blocked this turn.
Whenever Key to the City becomes untapped, you may pay {2}. If you do, draw a card.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Tainted Sigil

{T}, Sacrifice Tainted Sigil: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Knight of the White Orchid

First strike
When Knight of the White Orchid enters, if an opponent controls more lands than you, you may search your library for a Plains card, put it onto the battlefield, then shuffle.

Seal of the Guildpact

As Seal of the Guildpact enters, choose two colors.
Each spell you cast costs {1} less to cast for each of the chosen colors it is.

Bitter Revelation

Look at the top four cards of your library. Put two of them into your hand and the rest into your graveyard. You lose 2 life.

Night's Whisper

Swamp

Essence Pulse

You gain 2 life. Each creature gets -X/-X until end of turn, where X is the amount of life you gained this turn.

Karlov of the Ghost Council

Whenever you gain life, put two +1/+1 counters on Karlov of the Ghost Council.
{W}{B}, Remove six +1/+1 counters from Karlov of the Ghost Council: Exile target creature.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Masterwork of Ingenuity

You may have Masterwork of Ingenuity enter as a copy of any Equipment on the battlefield.

Ghostly Prison

Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Cathedral of War

Cathedral of War enters tapped.
Exalted (Whenever a creature you control attacks alone, that creature gets +1/+1 until end of turn.)
{T}: Add {C}.

Blood Reckoning

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Strider Harness

Equipped creature gets +1/+1 and has haste.
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Pearl Medallion

White spells you cast cost {1} less to cast.

Tragic Arrogance

For each player, you choose from among the permanents that player controls an artifact, a creature, an enchantment, and a planeswalker. Then each player sacrifices all other nonland permanents they control.

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice Silent Clearing: Draw a card.

Seraph Sanctuary

When Seraph Sanctuary enters, you gain 1 life.
Whenever an Angel you control enters, you gain 1 life.
{T}: Add {C}.

Isolated Chapel

Isolated Chapel enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters, you may pay 2 life. If you don't, it enters tapped.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Supernatural Stamina

Until end of turn, target creature gets +2/+0 and gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Undying Evil

Target creature gains undying until end of turn. (When it dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Ghost Quarter

{T}: Add {C}.
{T}, Sacrifice Ghost Quarter: Destroy target land. Its controller may search their library for a basic land card, put it onto the battlefield, then shuffle.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Sword of Vengeance

Equipped creature gets +2/+0 and has first strike, vigilance, trample, and haste.
Equip {3}

Opal Palace

{T}: Add {C}.
{1}, {T}: Add one mana of any color in your commander's color identity. If you spend this mana to cast your commander, it enters with a number of additional +1/+1 counters on it equal to the number of times it's been cast from the command zone this game.

Greed

Mage Hunter

Whenever an opponent casts or copies an instant or sorcery spell, they lose 1 life.

Gift of Estates

If an opponent controls more lands than you, search your library for up to three Plains cards, reveal them, put them into your hand, then shuffle.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Gift of Immortality

Enchant creature
When enchanted creature dies, return that card to the battlefield under its owner's control. Return Gift of Immortality to the battlefield attached to that creature at the beginning of the next end step.

Duelist's Heritage

Whenever one or more creatures attack, you may have target attacking creature gain double strike until end of turn.

Sword of the Animist

Equipped creature gets +1/+1.
Whenever equipped creature attacks, you may search your library for a basic land card, put it onto the battlefield tapped, then shuffle.
Equip {2}

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Withengar Unbound

Flying, intimidate, trample (A creature with intimidate can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever a player loses the game, put thirteen +1/+1 counters on Withengar Unbound.

Elbrus, the Binding Blade

Equipped creature gets +1/+0.
When equipped creature deals combat damage to a player, unattach Elbrus, the Binding Blade, then transform it.
Equip {1}

Elbrus, the Binding Blade // Withengar Unbound

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Radiant Fountain

When Radiant Fountain enters, you gain 2 life.
{T}: Add {C}.

Suture Priest

Whenever another creature you control enters, you may gain 1 life.
Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Kaya's Ghostform

Enchant creature or planeswalker you control
When enchanted permanent dies or is put into exile, return that card to the battlefield under your control.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Orzhov Signet

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Dark Tutelage

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Bastion Protector

Commander creatures you control get +2/+2 and have indestructible.

Champion's Helm

Equipped creature gets +2/+2.
As long as equipped creature is legendary, it has hexproof. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Haunted Cloak

Equipped creature has vigilance, trample, and haste.
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Jet Medallion

Black spells you cast cost {1} less to cast.

Temple of Silence

Temple of Silence enters tapped.
When Temple of Silence enters, scry 1.
{T}: Add {W} or {B}.

Elesh Norn, Grand Cenobite

Vigilance
Other creatures you control get +2/+2.
Creatures your opponents control get -2/-2.

Palace Siege

As Palace Siege enters, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Ankh of Mishra

Whenever a land enters, Ankh of Mishra deals 2 damage to that land's controller.

Scoured Barrens

Scoured Barrens enters tapped.
When Scoured Barrens enters, you gain 1 life.
{T}: Add {W} or {B}.