Sign in Blood

Target player draws two cards and loses 2 life.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Despark

Exile target permanent with mana value 4 or greater.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Exemplar of Light

Flying
Whenever you gain life, put a +1/+1 counter on this creature.
Whenever you put one or more +1/+1 counters on this creature, draw a card. This ability triggers only once each turn.

Gray Merchant of Asphodel

When this creature enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Greed

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on this creature and you gain 1 life.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Mai, Scornful Striker

First strike
Whenever a player casts a noncreature spell, they lose 2 life.

Swamp

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Arcane Signet

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Inkshield

Prevent all combat damage that would be dealt to you this turn. For each 1 damage prevented this way, create a 2/1 white and black Inkling creature token with flying.

Cleric Class

(Gain the next level as a sorcery to add its ability.)
If you would gain life, you gain that much life plus 1 instead.
{3}{W}: Level 2
Whenever you gain life, put a +1/+1 counter on target creature you control.
{4}{W}: Level 3
When this Class becomes level 3, return target creature card from your graveyard to the battlefield. You gain life equal to that creature's toughness.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice this artifact: Draw a card.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Bloodthirsty Conqueror

Flying, deathtouch
Whenever an opponent loses life, you gain that much life. (Damage causes loss of life.)

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on this enchantment. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if this enchantment has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Orzhov Signet

Vault of the Archangel

{T}: Add {C}.
{2}{W}{B}, {T}: Creatures you control gain deathtouch and lifelink until end of turn.

Plains

Grand Abolisher

During your turn, your opponents can't cast spells or activate abilities of artifacts, creatures, or enchantments.

Karlov of the Ghost Council

Whenever you gain life, put two +1/+1 counters on Karlov.
{W}{B}, Remove six +1/+1 counters from Karlov: Exile target creature.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Bojuka Bog

This land enters tapped.
When this land enters, exile target player's graveyard.
{T}: Add {B}.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Soul's Attendant

Whenever another creature enters, you may gain 1 life.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Pristine Talisman

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Fracture

Destroy target artifact, enchantment, or planeswalker.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Blood Artist

Whenever this creature or another creature dies, target player loses 1 life and you gain 1 life.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Raven Eagle

Flying
Whenever this creature enters or attacks, exile up to one target card from a graveyard. If a creature card is exiled this way, create a Clue token. (It's an artifact with "{2}, Sacrifice this token: Draw a card.")
Whenever you draw your second card each turn, each opponent loses 1 life and you gain 1 life.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Drana and Linvala

Flying, vigilance
Activated abilities of creatures your opponents control can't be activated.
Drana and Linvala has all activated abilities of all creatures your opponents control. You may spend mana as though it were mana of any color to activate those abilities.

Sol Ring

Starscape Cleric

Offspring {2}{B} (You may pay an additional {2}{B} as you cast this spell. If you do, when this creature enters, create a 1/1 token copy of it.)
Flying
This creature can't block.
Whenever you gain life, each opponent loses 1 life.

Night's Whisper

Suture Priest

Whenever another creature you control enters, you may gain 1 life.
Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Indulging Patrician

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your end step, if you gained 3 or more life this turn, each opponent loses 3 life.

Elas il-Kor, Sadistic Pilgrim

Deathtouch
Whenever another creature you control enters, you gain 1 life.
Whenever another creature you control dies, each opponent loses 1 life.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It is every creature type.)

Mortify

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Felidar Sovereign

Vigilance (Attacking doesn't cause this creature to tap.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your upkeep, if you have 40 or more life, you win the game.

Rhox Faithmender

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
If you would gain life, you gain twice that much life instead.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Dark Ritual

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Soul Warden

Whenever another creature enters, you gain 1 life.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: This artifact deals 50 damage to any target.

Tithe Drinker

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Vindicate

Marble Diamond

This artifact enters tapped.
{T}: Add {W}.

Norn's Annex

({W/P} can be paid with either {W} or 2 life.)
Creatures can't attack you or planeswalkers you control unless their controller pays {W/P} for each of those creatures.

Charcoal Diamond

This artifact enters tapped.
{T}: Add {B}.

Ghostly Prison

Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Creeping Bloodsucker

At the beginning of your upkeep, this creature deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice this artifact: Draw a card.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.