Aunt May

Whenever another creature you control enters, you gain 1 life. If it's a Spider, put a +1/+1 counter on it.

Ghost-Spider

Flying, vigilance, haste
Whenever you play a land from exile or cast a spell from exile, put a +1/+1 counter on Ghost-Spider.
Remove two counters from Ghost-Spider: Exile the top card of your library. You may play that card this turn.

Gwen Stacy

When Gwen Stacy enters, exile the top card of your library. You may play that card for as long as you control this creature.
{2}{U}{R}{W}: Transform Gwen Stacy. Activate only as a sorcery.

Gwen Stacy // Ghost-Spider

Spider-Man 2099

From the Future — You can't cast Spider-Man 2099 during your first, second, or third turns of the game.
Double strike, vigilance
At the beginning of your end step, if you've played a land or cast a spell this turn from anywhere other than your hand, Spider-Man 2099 deals damage equal to his power to any target.

Dragonlair Spider

Reach
Whenever an opponent casts a spell, create a 1/1 green Insect creature token.

Arasta of the Endless Web

Reach
Whenever an opponent casts an instant or sorcery spell, create a 1/2 green Spider creature token with reach.

Morophon, the Boundless

Changeling (This card is every creature type.)
As Morophon enters, choose a creature type.
Spells of the chosen type you cast cost {W}{U}{B}{R}{G} less to cast. This effect reduces only the amount of colored mana you pay.
Other creatures you control of the chosen type get +1/+1.

Roaming Throne

Ward {2}
As this creature enters, choose a creature type.
This creature is the chosen type in addition to its other types.
If a triggered ability of another creature you control of the chosen type triggers, it triggers an additional time.

Bloom Tender

{T}: For each color among permanents you control, add one mana of that color.

Silk, Web Weaver

Web-slinging {1}{G}{W} (You may cast this spell for {1}{G}{W} if you also return a tapped creature you control to its owner's hand.)
Whenever you cast a creature spell, create a 1/1 green and white Human Citizen creature token.
{3}{G}{W}: Creatures you control get +2/+2 and gain vigilance until end of turn.

Spectacular Spider-Man

Flash
{1}: Spectacular Spider-Man gains flying until end of turn.
{1}, Sacrifice Spectacular Spider-Man: Creatures you control gain hexproof and indestructible until end of turn.

Spider Manifestation

Reach
{T}: Add {R} or {G}.
Whenever you cast a spell with mana value 4 or greater, untap this creature.

Iron Spider, Stark Upgrade

Vigilance
{T}: Put a +1/+1 counter on each artifact creature and/or Vehicle you control.
{2}, Remove two +1/+1 counters from among artifacts you control: Draw a card.

Arachnogenesis

Create X 1/2 green Spider creature tokens with reach, where X is the number of creatures attacking you. Prevent all combat damage that would be dealt this turn by non-Spider creatures.

Spider-Ham, Peter Porker

When Spider-Ham enters, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
Animal May-Ham — Other Spiders, Boars, Bats, Bears, Birds, Cats, Dogs, Frogs, Jackals, Lizards, Mice, Otters, Rabbits, Raccoons, Rats, Squirrels, Turtles, and Wolves you control get +1/+1.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It is every creature type.)

Impostor Syndrome

Whenever a nontoken creature you control deals combat damage to a player, create a token that's a copy of it, except it isn't legendary.

Spider-Punk

Riot (This creature enters with your choice of a +1/+1 counter or haste.)
Other Spiders you control have riot.
Spells and abilities can't be countered.
Damage can't be prevented.

Twitching Doll

{T}: Add one mana of any color. Put a nest counter on this creature.
{T}, Sacrifice this creature: Create a 2/2 green Spider creature token with reach for each counter on this creature. Activate only as a sorcery.

Symbiote Spider-Man

Whenever this creature deals combat damage to a player, look at that many cards from the top of your library. Put one of them into your hand and the rest into your graveyard.
Find New Host — {2}{U/B}, Exile this card from your graveyard: Put a +1/+1 counter on target creature you control. It gains this card's other abilities. Activate only as a sorcery.

Araña, Heart of the Spider

Whenever you attack, put a +1/+1 counter on target attacking creature.
Whenever a modified creature you control deals combat damage to a player, exile the top card of your library. You may play that card this turn. (Equipment, Auras you control, and counters are modifications.)

Anti-Venom, Horrifying Healer

When Anti-Venom enters, if he was cast, return target creature card from your graveyard to the battlefield.
If damage would be dealt to Anti-Venom, prevent that damage and put that many +1/+1 counters on him.

Spinneret and Spiderling

Whenever you attack with two or more Spiders, put a +1/+1 counter on Spinneret and Spiderling.
Whenever Spinneret and Spiderling deals 4 or more damage, exile the top card of your library. Until the end of your next turn, you may play that card.

Radioactive Spider

Reach, deathtouch
Fateful Bite — {2}, Sacrifice this creature: Search your library for a Spider Hero card, reveal it, put it into your hand, then shuffle. Activate only as a sorcery.

Arachne, Psionic Weaver

Web-slinging {W} (You may cast this spell for {W} if you also return a tapped creature you control to its owner's hand.)
As Arachne enters, look at an opponent's hand, then choose a card type other than creature.
Spells of the chosen type cost {1} more to cast.

Madame Web, Clairvoyant

You may look at the top card of your library any time.
You may cast Spider spells and noncreature spells from the top of your library.
Whenever you attack, you may mill a card. (You may put the top card of your library into your graveyard.)

Cosmic Spider-Man

Flying, first strike, trample, lifelink, haste
At the beginning of combat on your turn, other Spiders you control gain flying, first strike, trample, lifelink, and haste until end of turn.

Gwenom, Remorseless

Deathtouch, lifelink
Whenever Gwenom attacks, until end of turn, you may look at the top card of your library any time and you may play cards from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.

Spider-Man, Peter Parker

Flying (This creature can't be blocked except by creatures with flying or reach.)
Whenever you gain life, put a +1/+1 counter on target creature you control. It gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Spider-Sense

Web-slinging {U} (You may cast this spell for {U} if you also return a tapped creature you control to its owner's hand.)
Counter target instant spell, sorcery spell, or triggered ability.

Scarlet Spider, Ben Reilly

Web-slinging {R}{G} (You may cast this spell for {R}{G} if you also return a tapped creature you control to its owner's hand.)
Trample
Sensational Save — If Scarlet Spider was cast using web-slinging, he enters with X +1/+1 counters on him, where X is the mana value of the returned creature.

Superior Spider-Man

Mind Swap — You may have Superior Spider-Man enter as a copy of any creature card in a graveyard, except his name is Superior Spider-Man and he's a 4/4 Spider Human Hero in addition to his other types. When you do, exile that card.

SP//dr, Piloted by Peni

Vigilance
When SP//dr enters, put a +1/+1 counter on target creature.
Whenever a modified creature you control deals combat damage to a player, draw a card. (Equipment, Auras you control, and counters are modifications.)

Mary Jane Watson

Whenever a Spider you control enters, draw a card. This ability triggers only once each turn.

Thantis, the Warweaver

Vigilance, reach
All creatures attack each combat if able.
Whenever a creature attacks you or a planeswalker you control, put a +1/+1 counter on Thantis.