Fracture

Destroy target artifact, enchantment, or planeswalker.

Norn's Annex

({W/P} can be paid with either {W} or 2 life.)
Creatures can't attack you or planeswalkers you control unless their controller pays {W/P} for each of those creatures.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Divinity of Pride

Flying, lifelink
Divinity of Pride gets +4/+4 as long as you have 25 or more life.

Felidar Sovereign

Vigilance (Attacking doesn't cause this creature to tap.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your upkeep, if you have 40 or more life, you win the game.

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Drogskol Reaver

Flying
Double strike (This creature deals both first-strike and regular combat damage.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Whenever you gain life, draw a card.

Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is Esper Sentinel's power.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Vault of the Archangel

{T}: Add {C}.
{2}{W}{B}, {T}: Creatures you control gain deathtouch and lifelink until end of turn.

maybe

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Soul Warden

Whenever another creature enters, you gain 1 life.

Land Tax

At the beginning of your upkeep, if an opponent controls more lands than you, you may search your library for up to three basic land cards, reveal them, put them into your hand, then shuffle.

Oloro, Ageless Ascetic

At the beginning of your upkeep, you gain 2 life.
Whenever you gain life, you may pay {1}. If you do, draw a card and each opponent loses 1 life.
At the beginning of your upkeep, if Oloro, Ageless Ascetic is in the command zone, you gain 2 life.

Crawlspace

No more than two creatures can attack you each combat.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Day of Judgment

Approach of the Second Sun

If this spell was cast from your hand and you've cast another spell named Approach of the Second Sun this game, you win the game. Otherwise, put Approach of the Second Sun into its owner's library seventh from the top and you gain 7 life.

Maze of Ith

{T}: Untap target attacking creature. Prevent all combat damage that would be dealt to and dealt by that creature this turn.

Greed

Sea of Clouds

Sea of Clouds enters tapped unless you have two or more opponents.
{T}: Add {W} or {U}.

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform Chalice of Life.

Chalice of Life // Chalice of Death

Sunken Hollow

({T}: Add {U} or {B}.)
Sunken Hollow enters tapped unless you control two or more basic lands.

Azor's Elocutors

At the beginning of your upkeep, put a filibuster counter on Azor's Elocutors. Then if Azor's Elocutors has five or more filibuster counters on it, you win the game.
Whenever a source deals damage to you, remove a filibuster counter from Azor's Elocutors.

Sorin, Grim Nemesis

+1: Reveal the top card of your library and put that card into your hand. Each opponent loses life equal to its mana value.
−X: Sorin, Grim Nemesis deals X damage to target creature or planeswalker and you gain X life.
−9: Create a number of 1/1 black Vampire Knight creature tokens with lifelink equal to the highest life total among all players.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Swamp

Ajani's Pridemate

Whenever you gain life, put a +1/+1 counter on this creature.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Sorin, Vengeful Bloodlord

During your turn, creatures and planeswalkers you control have lifelink.
+2: Sorin, Vengeful Bloodlord deals 1 damage to target player or planeswalker.
−X: Return target creature card with mana value X from your graveyard to the battlefield. That creature is a Vampire in addition to its other types.

Ajani, Strength of the Pride

+1: You gain life equal to the number of creatures you control plus the number of planeswalkers you control.
−2: Create a 2/2 white Cat Soldier creature token named Ajani's Pridemate with "Whenever you gain life, put a +1/+1 counter on Ajani's Pridemate."
0: If you have at least 15 life more than your starting life total, exile Ajani, Strength of the Pride and each artifact and creature your opponents control.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Archaeomancer's Map

When Archaeomancer's Map enters, search your library for up to two basic Plains cards, reveal them, put them into your hand, then shuffle.
Whenever a land an opponent controls enters, if that player controls more lands than you, you may put a land card from your hand onto the battlefield.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Prairie Stream

({T}: Add {W} or {U}.)
Prairie Stream enters tapped unless you control two or more basic lands.

Utter End

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Morphic Pool

Morphic Pool enters tapped unless you have two or more opponents.
{T}: Add {U} or {B}.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Grimclimb Pathway

Brightclimb Pathway

Brightclimb Pathway // Grimclimb Pathway

Thought Vessel

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Dawn of Hope

Whenever you gain life, you may pay {2}. If you do, draw a card.
{3}{W}: Create a 1/1 white Soldier creature token with lifelink.

Ghostly Prison

Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Hallowed Fountain

({T}: Add {W} or {U}.)
As Hallowed Fountain enters, you may pay 2 life. If you don't, it enters tapped.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters, you may pay 2 life. If you don't, it enters tapped.

Obelisk of Esper

Island

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Propaganda

Esper Panorama

{T}: Add {C}.
{1}, {T}, Sacrifice Esper Panorama: Search your library for a basic Plains, Island, or Swamp card, put it onto the battlefield tapped, then shuffle.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Serra Ascendant

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
As long as you have 30 or more life, Serra Ascendant gets +5/+5 and has flying.

Murkwater Pathway

Clearwater Pathway

Clearwater Pathway // Murkwater Pathway

Sol Ring

Watery Grave

({T}: Add {U} or {B}.)
As Watery Grave enters, you may pay 2 life. If you don't, it enters tapped.

Plains

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Pristine Talisman

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Boon Reflection

If you would gain life, you gain twice that much life instead.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Despark

Exile target permanent with mana value 4 or greater.

Counterspell

Arcane Signet

Angel of Destiny

Flying, double strike
Whenever a creature you control deals combat damage to a player, you and that player each gain that much life.
At the beginning of your end step, if you have at least 15 life more than your starting life total, each player Angel of Destiny attacked this turn loses the game.

Mistgate Pathway

Hengegate Pathway

Hengegate Pathway // Mistgate Pathway

Vault of Champions

Vault of Champions enters tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Vindicate

Crested Sunmare

Other Horses you control have indestructible.
At the beginning of each end step, if you gained life this turn, create a 5/5 white Horse creature token.

Ajani Goldmane

+1: You gain 2 life.
−1: Put a +1/+1 counter on each creature you control. Those creatures gain vigilance until end of turn.
−6: Create a white Avatar creature token. It has "This creature's power and toughness are each equal to your life total."

Venser's Journal

You have no maximum hand size.
At the beginning of your upkeep, you gain 1 life for each card in your hand.

Sun Droplet

Whenever you're dealt damage, put that many charge counters on Sun Droplet.
At the beginning of each upkeep, you may remove a charge counter from Sun Droplet. If you do, you gain 1 life.