Damnable Pact

Target player draws X cards and loses X life.

Gallowbraid

Trample
Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Ancient Craving

You draw three cards and you lose 3 life.

Lurking Evil

Pay half your life, rounded up: Lurking Evil becomes a 4/4 Phyrexian Horror creature with flying.

Live Fast

You draw two cards, lose 2 life, and get {E}{E} (two energy counters).

Carrion Howler

Pay 1 life: Carrion Howler gets +2/-1 until end of turn.

Village Rites

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

Caustic Tar

Enchant land
Enchanted land has "{T}: Target player loses 3 life."

Dark Ritual

Grimclaw Bats

Flying
{B}, Pay 1 life: Grimclaw Bats gets +1/+1 until end of turn.

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Charcoal Diamond

Charcoal Diamond enters tapped.
{T}: Add {B}.

Marshland Bloodcaster

Flying
{1}{B}, {T}: Rather than pay the mana cost of the next spell you cast this turn, you may pay life equal to that spell's mana value.

Cabal Ritual

Add {B}{B}{B}.
Threshold — Add {B}{B}{B}{B}{B} instead if seven or more cards are in your graveyard.

Worn Powerstone

Worn Powerstone enters tapped.
{T}: Add {C}{C}.

Minion of the Wastes

Trample
As Minion of the Wastes enters, pay any amount of life.
Minion of the Wastes's power and toughness are each equal to the life paid as it entered.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Banewasp Affliction

Enchant creature
When enchanted creature dies, that creature's controller loses life equal to its toughness.

Audacious Thief

Whenever Audacious Thief attacks, you draw a card and you lose 1 life.

Souldrinker

Pay 3 life: Put a +1/+1 counter on Souldrinker.

Vesper Ghoul

{T}, Pay 1 life: Add one mana of any color.

Bile Urchin

Sacrifice Bile Urchin: Target player loses 1 life.

Tavern Swindler

{T}, Pay 3 life: Flip a coin. If you win the flip, you gain 6 life.

Bog Witch

Soul Channeling

Enchant creature
Pay 2 life: Regenerate enchanted creature.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Bane Alley Blackguard

Bellowing Saddlebrute

Raid — When Bellowing Saddlebrute enters, you lose 4 life unless you attacked this turn.

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Hedron Archive

{T}: Add {C}{C}.
{2}, {T}, Sacrifice this artifact: Draw two cards.

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Songs of the Damned

Add {B} for each creature card in your graveyard.

Shadowcloak Vampire

Pay 2 life: Shadowcloak Vampire gains flying until end of turn. (It can't be blocked except by creatures with flying or reach.)

Kuro, Pitlord

At the beginning of your upkeep, sacrifice Kuro, Pitlord unless you pay {B}{B}{B}{B}.
Pay 1 life: Target creature gets -1/-1 until end of turn.

Boon of Erebos

Target creature gets +2/+0 until end of turn. Regenerate it. You lose 2 life.

Sign in Blood

Target player draws two cards and loses 2 life.

Succumb to Temptation

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Phyrexian Rager

When Phyrexian Rager enters, you draw a card and you lose 1 life.

Phyrexian Lens

Blood Price

Look at the top four cards of your library. Put two of them into your hand and the rest on the bottom of your library in any order. You lose 2 life.

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Sisay's Ring

Blessing of Leeches

Flash
Enchant creature
At the beginning of your upkeep, you lose 1 life.
{0}: Regenerate enchanted creature.

Swamp

Standing Stones

{1}, {T}, Pay 1 life: Add one mana of any color.

Numai Outcast

Bushido 2 (Whenever this creature blocks or becomes blocked, it gets +2/+2 until end of turn.)
{B}, Pay 5 life: Regenerate Numai Outcast.

Baleful Force

At the beginning of each upkeep, you draw a card and you lose 1 life.

Murderous Betrayal

{B}{B}, Pay half your life, rounded up: Destroy target nonblack creature. It can't be regenerated.

Funeral Rites

You draw two cards, lose 2 life, then mill two cards.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Sinister Concoction

{B}, Pay 1 life, Mill a card, Discard a card, Sacrifice Sinister Concoction: Destroy target creature.

Book of Rass

Dusk Legion Zealot

When Dusk Legion Zealot enters, you draw a card and you lose 1 life.

Culling the Weak

As an additional cost to cast this spell, sacrifice a creature.
Add {B}{B}{B}{B}.

Phyrexian Reclamation

{1}{B}, Pay 2 life: Return target creature card from your graveyard to your hand.

Strands of Night

{B}{B}, Pay 2 life, Sacrifice a Swamp: Return target creature card from your graveyard to the battlefield.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Midnight Reaper

Whenever a nontoken creature you control dies, this creature deals 1 damage to you and you draw a card.