Desynchronization

Return each nonland permanent that's not historic to its owner's hand. (Artifacts, legendaries, and Sagas are historic.)

Wrath of God

Destroy all creatures. They can't be regenerated.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Bear Umbra

Enchant creature
Enchanted creature gets +2/+2 and has "Whenever this creature attacks, untap all lands you control."
Umbra armor (If enchanted creature would be destroyed, instead remove all damage from it and destroy this Aura.)

Cyclonic Rift

Return target nonland permanent you don't control to its owner's hand.
Overload {6}{U} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Strix Serenade

Counter target artifact, creature, or planeswalker spell. Its controller creates a 2/2 blue Bird creature token with flying.

Leyline of Anticipation

If this card is in your opening hand, you may begin the game with it on the battlefield.
You may cast spells as though they had flash.

White Sun's Twilight

You gain X life. Create X 1/1 colorless Phyrexian Mite artifact creature tokens with toxic 1 and "This token can't block." If X is 5 or more, destroy all other creatures. (Players dealt combat damage by a creature with toxic 1 also get a poison counter.)

Toski, Bearer of Secrets

This spell can't be countered.
Indestructible
Toski attacks each combat if able.
Whenever a creature you control deals combat damage to a player, draw a card.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Simic Signet

Farseek

Search your library for a Plains, Island, Swamp, or Mountain card, put it onto the battlefield tapped, then shuffle.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Karametra, God of Harvests

Indestructible
As long as your devotion to green and white is less than seven, Karametra isn't a creature.
Whenever you cast a creature spell, you may search your library for a Forest or Plains card, put it onto the battlefield tapped, then shuffle.

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Nature's Will

Whenever one or more creatures you control deal combat damage to a player, tap all lands that player controls and untap all lands you control.

Ishai, Ojutai Dragonspeaker

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Ishai.
Partner (You can have two commanders if both have partner.)

Slash the Ranks

Destroy all creatures and planeswalkers except for commanders.

Rampant Growth

Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Anara, Wolvid Familiar

During your turn, commanders you control have indestructible. (Effects that say "destroy" don't destroy them. A creature with indestructible can't be destroyed by damage.)
Partner (You can have two commanders if both have partner.)

Thran Dynamo

Sab-Sunen, Luxa Embodied

Reach, trample, indestructible
Sab-Sunen can't attack or block unless it has an even number of counters on it. (Zero is even.)
At the beginning of your first main phase, put a +1/+1 counter on Sab-Sunen. Then if it has an odd number of counters on it, draw two cards.

Final Showdown

Spree (Choose one or more additional costs.)
+ {1} — All creatures lose all abilities until end of turn.
+ {1} — Choose a creature you control. It gains indestructible until end of turn.
+ {3}{W}{W} — Destroy all creatures.

Negate

Ulamog, the Infinite Gyre

When you cast this spell, destroy target permanent.
Indestructible
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents of their choice.)
When Ulamog is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.

Split Up

Choose one —
• Destroy all tapped creatures.
• Destroy all untapped creatures.

Seedborn Muse

Untap all permanents you control during each other player's untap step.

Force of Negation

If it's not your turn, you may exile a blue card from your hand rather than pay this spell's mana cost.
Counter target noncreature spell. If that spell is countered this way, exile it instead of putting it into its owner's graveyard.

Selesnya Signet

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Kodama's Reach

Search your library for up to two basic land cards, reveal those cards, put one onto the battlefield tapped and the other into your hand, then shuffle.

Coastal Piracy

Whenever a creature you control deals combat damage to an opponent, you may draw a card.

An Offer You Can't Refuse

Counter target noncreature spell. Its controller creates two Treasure tokens. (They're artifacts with "{T}, Sacrifice this token: Add one mana of any color.")

Disenchant

Stroke of Midnight

Destroy target nonland permanent. Its controller creates a 1/1 white Human creature token.

Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is this creature's power.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Reconnaissance Mission

Whenever a creature you control deals combat damage to a player, you may draw a card.
Cycling {2} ({2}, Discard this card: Draw a card.)

Counterspell

Wilderness Reclamation

At the beginning of your end step, untap all lands you control.

Ephara, God of the Polis

Indestructible
As long as your devotion to white and blue is less than seven, Ephara isn't a creature.
At the beginning of each upkeep, if you had another creature enter the battlefield under your control last turn, draw a card.

Azorius Signet

Kruphix, God of Horizons

Indestructible
As long as your devotion to green and blue is less than seven, Kruphix isn't a creature.
You have no maximum hand size.
If you would lose unspent mana, that mana becomes colorless instead.

Mystic Remora

Cumulative upkeep {1} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
Whenever an opponent casts a noncreature spell, you may draw a card unless that player pays {4}.

Thassa, God of the Sea

Indestructible
As long as your devotion to blue is less than five, Thassa isn't a creature. (Each {U} in the mana costs of permanents you control counts toward your devotion to blue.)
At the beginning of your upkeep, scry 1.
{1}{U}: Target creature you control can't be blocked this turn.

Nylea, God of the Hunt

Indestructible
As long as your devotion to green is less than five, Nylea isn't a creature. (Each {G} in the mana costs of permanents you control counts toward your devotion to green.)
Other creatures you control have trample.
{3}{G}: Target creature gets +2/+2 until end of turn.

Plains

Fierce Guardianship

If you control a commander, you may cast this spell without paying its mana cost.
Counter target noncreature spell.

Reconnaissance

{0}: Remove target attacking creature you control from combat and untap it. (If you activate during end of combat, the creature will untap after it deals combat damage.)

Forest

Rhonas the Indomitable

Deathtouch, indestructible
Rhonas can't attack or block unless you control another creature with power 4 or greater.
{2}{G}: Another target creature gets +2/+0 and gains trample until end of turn.

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Brokers Ascendancy

At the beginning of your end step, put a +1/+1 counter on each creature you control and a loyalty counter on each planeswalker you control.

Beast Within

Destroy target permanent. Its controller creates a 3/3 green Beast creature token.

Swan Song

Counter target enchantment, instant, or sorcery spell. Its controller creates a 2/2 blue Bird creature token with flying.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Curse of the Swine

Exile X target creatures. For each creature exiled this way, its controller creates a 2/2 green Boar creature token.

Trouble in Pairs

If an opponent would begin an extra turn, that player skips that turn instead.
Whenever an opponent attacks you with two or more creatures, draws their second card each turn, or casts their second spell each turn, you draw a card.

River's Rebuke

Return all nonland permanents target player controls to their owner's hand.

Cultivate

Vedalken Orrery

You may cast spells as though they had flash.

Enduring Curiosity

Flash
Whenever a creature you control deals combat damage to a player, draw a card.
When Enduring Curiosity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Three Visits

Search your library for a Forest card, put it onto the battlefield, then shuffle.

Creepy Doll

Indestructible
Whenever this creature deals combat damage to a creature, flip a coin. If you win the flip, destroy that creature.

Aetherize

Return all attacking creatures to their owner's hand.

Wash Out

Return all permanents of the color of your choice to their owners' hands.

Nature's Claim

Destroy target artifact or enchantment. Its controller gains 4 life.

Predator Ooze

Indestructible (Damage and effects that say "destroy" don't destroy this creature.)
Whenever this creature attacks, put a +1/+1 counter on it.
Whenever a creature dealt damage by this creature this turn dies, put a +1/+1 counter on this creature.

Mana Drain

Counter target spell. At the beginning of your next main phase, add an amount of {C} equal to that spell's mana value.

Hardened Scales

If one or more +1/+1 counters would be put on a creature you control, that many plus one +1/+1 counters are put on it instead.

Island

Bident of Thassa

Whenever a creature you control deals combat damage to a player, you may draw a card.
{1}{U}, {T}: Creatures your opponents control attack this turn if able.

Talisman of Unity

{T}: Add {C}.
{T}: Add {G} or {W}. This artifact deals 1 damage to you.

Heliod, God of the Sun

Indestructible
As long as your devotion to white is less than five, Heliod isn't a creature. (Each {W} in the mana costs of permanents you control counts toward your devotion to white.)
Other creatures you control have vigilance.
{2}{W}{W}: Create a 2/1 white Cleric enchantment creature token.

Dovin's Veto

This spell can't be countered.
Counter target noncreature spell.

Talisman of Curiosity

{T}: Add {C}.
{T}: Add {G} or {U}. This artifact deals 1 damage to you.

Nature's Lore

Search your library for a Forest card, put that card onto the battlefield, then shuffle.

Force of Will

You may pay 1 life and exile a blue card from your hand rather than pay this spell's mana cost.
Counter target spell.