Descent into Madness

At the beginning of your upkeep, put a despair counter on Descent into Madness, then each player exiles X permanents they control and/or cards from their hand, where X is the number of despair counters on Descent into Madness.

Breaking Point

Any player may have Breaking Point deal 6 damage to them. If no one does, destroy all creatures. Creatures destroyed this way can't be regenerated.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice.

Aether Flash

Whenever a creature enters, Aether Flash deals 2 damage to it.

Psychogenic Probe

Whenever a spell or ability causes a player to shuffle their library, Psychogenic Probe deals 2 damage to that player.

Sands of Time

Each player skips their untap step.
At the beginning of each player's upkeep, that player simultaneously untaps each tapped artifact, creature, and land they control and taps each untapped artifact, creature, and land they control.

Forbidden Ritual

Sacrifice a nontoken permanent. If you do, target opponent loses 2 life unless that player sacrifices a permanent of their choice or discards a card. You may repeat this process any number of times.

Thought Prison

Imprint — When Thought Prison enters, you may have target player reveal their hand. If you do, choose a nonland card from it and exile that card.
Whenever a player casts a spell that shares a color or mana value with the exiled card, Thought Prison deals 2 damage to that player.

Treasure Nabber

Whenever an opponent taps an artifact for mana, gain control of that artifact until the end of your next turn.

Demanding Dragon

Flying
When Demanding Dragon enters, it deals 5 damage to target opponent unless that player sacrifices a creature of their choice.

Bladegriff Prototype

Flying
Whenever Bladegriff Prototype deals combat damage to a player, destroy target nonland permanent of that player's choice that one of your opponents controls.

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Everlasting Torment

Players can't gain life.
Damage can't be prevented.
All damage is dealt as though its source had wither. (A source with wither deals damage to creatures in the form of -1/-1 counters.)

Endless Whispers

Each creature has "When this creature dies, choose target opponent. That player puts this card from its owner's graveyard onto the battlefield under their control at the beginning of the next end step."

Akoum Refuge

Akoum Refuge enters tapped.
When Akoum Refuge enters, you gain 1 life.
{T}: Add {B} or {R}.

Horobi, Death's Wail

Flying
Whenever a creature becomes the target of a spell or ability, destroy that creature.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Mountain

Enchanter's Bane

At the beginning of your end step, target enchantment deals damage equal to its mana value to its controller unless that player sacrifices it.

Explosion of Riches

Draw a card, then each other player may draw a card. Whenever a card is drawn this way, Explosion of Riches deals 5 damage to target opponent chosen at random from among your opponents.

Capricious Efreet

At the beginning of your upkeep, choose target nonland permanent you control and up to two target nonland permanents you don't control. Destroy one of them at random.

Risk Factor

Target opponent may have Risk Factor deal 4 damage to them. If that player doesn't, you draw three cards.
Jump-start (You may cast this card from your graveyard by discarding a card in addition to paying its other costs. Then exile this card.)

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Sin Prodder

Menace
At the beginning of your upkeep, reveal the top card of your library. Any opponent may have you put that card into your graveyard. If a player does, Sin Prodder deals damage to that player equal to that card's mana value. Otherwise, put that card into your hand.

Torment of Scarabs

Enchant player
At the beginning of enchanted player's upkeep, that player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.

Aether Sting

Whenever an opponent casts a creature spell, Aether Sting deals 1 damage to that player.

Sulfuric Vortex

At the beginning of each player's upkeep, Sulfuric Vortex deals 2 damage to that player.
If a player would gain life, that player gains no life instead.

Choice of Damnations

Target opponent chooses a number. You may have that player lose that much life. If you don't, that player sacrifices all but that many permanents of their choice.

Anowon, the Ruin Sage

At the beginning of your upkeep, each player sacrifices a non-Vampire creature of their choice.

Butcher of Malakir

Flying
Whenever Butcher of Malakir or another creature you control dies, each opponent sacrifices a creature of their choice.

Last One Standing

Choose a creature at random, then destroy the rest.

Curse of Vengeance

Enchant player
Whenever enchanted player casts a spell, put a spite counter on Curse of Vengeance.
When enchanted player loses the game, you gain X life and draw X cards, where X is the number of spite counters on Curse of Vengeance.

Browbeat

Any player may have Browbeat deal 5 damage to them. If no one does, target player draws three cards.

Bloodfell Caves

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {B} or {R}.

Mage Hunter

Whenever an opponent casts or copies an instant or sorcery spell, they lose 1 life.

Death Pits of Rath

Whenever a creature is dealt damage, destroy it. It can't be regenerated.

Dwarven Driller

{T}: Destroy target land unless its controller has Dwarven Driller deal 2 damage to them.

Remorseless Punishment

Target opponent loses 5 life unless that player discards two cards or sacrifices a creature or planeswalker of their choice. Repeat this process once.

Monomania

Target player chooses a card in their hand and discards the rest.

Swamp

Rakdos Guildgate

This land enters tapped.
{T}: Add {B} or {R}.

Elkin Lair

At the beginning of each player's upkeep, that player exiles a card at random from their hand. The player may play that card this turn. At the beginning of the next end step, if the player hasn't played the card, they put it into their graveyard.

Emissary of Grudges

Flying, haste
As Emissary of Grudges enters, secretly choose an opponent.
Reveal the player you chose: Choose new targets for target spell or ability if it's controlled by the chosen player and if it targets you or a permanent you control. Activate only once.

Spellshock

Whenever a player casts a spell, Spellshock deals 2 damage to that player.

Curse of the Cabal

Target player sacrifices half the permanents they control of their choice, rounded down.
Suspend 2—{2}{B}{B} (Rather than cast this card from your hand, you may pay {2}{B}{B} and exile it with two time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)
At the beginning of each player's upkeep, if Curse of the Cabal is suspended, that player may sacrifice a permanent of their choice. If the player does, put two time counters on Curse of the Cabal.

Sol Ring

Sower of Discord

Flying
As Sower of Discord enters, choose two players.
Whenever damage is dealt to one of the chosen players, the other chosen player also loses that much life.

Dingus Staff

Whenever a creature dies, Dingus Staff deals 2 damage to that creature's controller.

Glistening Oil

Enchant creature
Enchanted creature has infect.
At the beginning of your upkeep, put a -1/-1 counter on enchanted creature.
When Glistening Oil is put into a graveyard from the battlefield, return Glistening Oil to its owner's hand.

Fraying Omnipotence

Each player loses half their life, then discards half the cards in their hand, then sacrifices half the creatures they control of their choice. Round up each time.

Nettlevine Blight

Enchant creature or land
Enchanted permanent has "At the beginning of your end step, sacrifice this permanent and attach Nettlevine Blight to a creature or land you control."

Sword-Point Diplomacy

Reveal the top three cards of your library. For each of those cards, put that card into your hand unless any opponent pays 3 life. Then exile the rest.

Do or Die

Separate all creatures target player controls into two piles. Destroy all creatures in the pile of that player's choice. They can't be regenerated.

Soot Imp

Flying
Whenever a player casts a nonblack spell, that player loses 1 life.

Captive Audience

Captive Audience enters under the control of an opponent of your choice.
At the beginning of your upkeep, choose one that hasn't been chosen —
• Your life total becomes 4.
• Discard your hand.
• Each opponent creates five 2/2 black Zombie creature tokens.

Urborg Volcano

Urborg Volcano enters tapped.
{T}: Add {B} or {R}.

Knowledge Pool

Imprint — When Knowledge Pool enters, each player exiles the top three cards of their library.
Whenever a player casts a spell from their hand, that player exiles it. If the player does, they may cast a spell from among other cards exiled with Knowledge Pool without paying its mana cost.

Allure of the Unknown

Reveal the top six cards of your library. An opponent exiles a nonland card from among them, then you put the rest into your hand. That opponent may cast the exiled card without paying its mana cost.

Chaos Warp

The owner of target permanent shuffles it into their library, then reveals the top card of their library. If it's a permanent card, they put it onto the battlefield.

Nefarox, Overlord of Grixis

Flying
Exalted (Whenever a creature you control attacks alone, that creature gets +1/+1 until end of turn.)
Whenever Nefarox, Overlord of Grixis attacks alone, defending player sacrifices a creature of their choice.

Possibility Storm

Whenever a player casts a spell from their hand, that player exiles it, then exiles cards from the top of their library until they exile a card that shares a card type with it. That player may cast that card without paying its mana cost. Then they put all cards exiled with Possibility Storm on the bottom of their library in a random order.

Rakdos Carnarium

Rakdos Carnarium enters tapped.
When Rakdos Carnarium enters, return a land you control to its owner's hand.
{T}: Add {B}{R}.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Plague of Vermin

Starting with you, each player may pay any amount of life. Repeat this process until no one pays life. Each player creates a 1/1 black Rat creature token for each 1 life they paid this way.

Plaguecrafter

When Plaguecrafter enters, each player sacrifices a creature or planeswalker of their choice. Each player who can't discards a card.

Illicit Auction

Each player may bid life for control of target creature. You start the bidding with a bid of 0. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and gains control of the creature. (This effect lasts indefinitely.)

Mogis, God of Slaughter

Indestructible
As long as your devotion to black and red is less than seven, Mogis isn't a creature.
At the beginning of each opponent's upkeep, Mogis deals 2 damage to that player unless they sacrifice a creature of their choice.

Lethal Vapors

Whenever a creature enters, destroy it.
{0}: Destroy Lethal Vapors. You skip your next turn. Any player may activate this ability.

Necrotic Plague

Enchant creature
Enchanted creature has "At the beginning of your upkeep, sacrifice this creature."
When enchanted creature dies, its controller chooses target creature one of their opponents controls. Return Necrotic Plague from its owner's graveyard to the battlefield attached to that creature.