Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Traveling Plague

Enchant creature
At the beginning of each upkeep, put a plague counter on this Aura.
Enchanted creature gets -1/-1 for each plague counter on this Aura.
When enchanted creature leaves the battlefield, that creature's controller returns this Aura from its owner's graveyard to the battlefield.

Malignant Growth

Cumulative upkeep {1} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
At the beginning of your upkeep, put a growth counter on this enchantment.
At the beginning of each opponent's draw step, that player draws an additional card for each growth counter on this enchantment, then this enchantment deals damage to the player equal to the number of cards they drew this way.

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control of their choice, then sacrifices a third of the lands they control of their choice. Round up each time.