Pact of the Titan

Create a 4/4 red Giant creature token.
At the beginning of your next upkeep, pay {4}{R}. If you don't, you lose the game.

Angel of Destiny

Flying, double strike
Whenever a creature you control deals combat damage to a player, you and that player each gain that much life.
At the beginning of your end step, if you have at least 15 life more than your starting life total, each player Angel of Destiny attacked this turn loses the game.

Vraska the Unseen

+1: Until your next turn, whenever a creature deals combat damage to Vraska the Unseen, destroy that creature.
−3: Destroy target nonland permanent.
−7: Create three 1/1 black Assassin creature tokens with "Whenever this creature deals combat damage to a player, that player loses the game."

Celestial Convergence

Celestial Convergence enters with seven omen counters on it.
At the beginning of your upkeep, remove an omen counter from Celestial Convergence. If there are no omen counters on Celestial Convergence, the player with the highest life total wins the game. If two or more players are tied for highest life total, the game is a draw.

Demonic Pact

At the beginning of your upkeep, choose one that hasn't been chosen —
• This enchantment deals 4 damage to any target and you gain 4 life.
• Target opponent discards two cards.
• Draw two cards.
• You lose the game.

Hellkite Tyrant

Flying, trample
Whenever Hellkite Tyrant deals combat damage to a player, gain control of all artifacts that player controls.
At the beginning of your upkeep, if you control twenty or more artifacts, you win the game.

Final Fortune

Take an extra turn after this one. At the beginning of that turn's end step, you lose the game.

Slaughter Pact

Destroy target nonblack creature.
At the beginning of your next upkeep, pay {2}{B}. If you don't, you lose the game.

Test of Endurance

At the beginning of your upkeep, if you have 50 or more life, you win the game.

Glorious End

End the turn. (Exile all spells and abilities from the stack, including this card. The player whose turn it is discards down to their maximum hand size. Damage wears off, and "this turn" and "until end of turn" effects end.)
At the beginning of your next end step, you lose the game.

Nefarious Lich

If damage would be dealt to you, exile that many cards from your graveyard instead. If you can't, you lose the game.
If you would gain life, draw that many cards instead.
When Nefarious Lich leaves the battlefield, you lose the game.

Felidar Sovereign

Vigilance (Attacking doesn't cause this creature to tap.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your upkeep, if you have 40 or more life, you win the game.

Mirrodin Besieged

As Mirrodin Besieged enters, choose Mirran or Phyrexian.
• Mirran — Whenever you cast an artifact spell, create a 1/1 colorless Myr artifact creature token.
• Phyrexian — At the beginning of your end step, draw a card, then discard a card. Then if there are fifteen or more artifact cards in your graveyard, target opponent loses the game.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Liliana's Contract

When Liliana's Contract enters, you draw four cards and you lose 4 life.
At the beginning of your upkeep, if you control four or more Demons with different names, you win the game.

Gideon of the Trials

+1: Until your next turn, prevent all damage target permanent would deal.
0: Until end of turn, Gideon of the Trials becomes a 4/4 Human Soldier creature with indestructible that's still a planeswalker. Prevent all damage that would be dealt to him this turn.
0: You get an emblem with "As long as you control a Gideon planeswalker, you can't lose the game and your opponents can't win the game."

Withengar Unbound

Flying, intimidate, trample (A creature with intimidate can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever a player loses the game, put thirteen +1/+1 counters on Withengar Unbound.

Elbrus, the Binding Blade

Equipped creature gets +1/+0.
When equipped creature deals combat damage to a player, unattach Elbrus, the Binding Blade, then transform it.
Equip {1}

Elbrus, the Binding Blade // Withengar Unbound

Strixhaven Stadium

{T}: Add {C}. Put a point counter on Strixhaven Stadium.
Whenever a creature deals combat damage to you, remove a point counter from Strixhaven Stadium.
Whenever a creature you control deals combat damage to an opponent, put a point counter on Strixhaven Stadium. Then if it has ten or more point counters on it, remove them all and that player loses the game.

Soul Echo

Soul Echo enters with X echo counters on it.
You don't lose the game for having 0 or less life.
At the beginning of your upkeep, sacrifice Soul Echo if there are no echo counters on it. Otherwise, target opponent may choose that for each 1 damage that would be dealt to you until your next upkeep, you remove an echo counter from Soul Echo instead.

Phage the Untouchable

When Phage the Untouchable enters, if you didn't cast it from your hand, you lose the game.
Whenever Phage deals combat damage to a creature, destroy that creature. It can't be regenerated.
Whenever Phage deals combat damage to a player, that player loses the game.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Intervention Pact

The next time a source of your choice would deal damage to you this turn, prevent that damage. You gain life equal to the damage prevented this way.
At the beginning of your next upkeep, pay {1}{W}{W}. If you don't, you lose the game.

Door to Nothingness

Door to Nothingness enters tapped.
{W}{W}{U}{U}{B}{B}{R}{R}{G}{G}, {T}, Sacrifice Door to Nothingness: Target player loses the game.

Epic Struggle

At the beginning of your upkeep, if you control twenty or more creatures, you win the game.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Blood Tyrant

Flying, trample
At the beginning of your upkeep, each player loses 1 life. Put a +1/+1 counter on Blood Tyrant for each 1 life lost this way.
Whenever a player loses the game, put five +1/+1 counters on Blood Tyrant.

Barren Glory

At the beginning of your upkeep, if you control no permanents other than Barren Glory and have no cards in hand, you win the game.

Forbidden Crypt

If you would draw a card, return a card from your graveyard to your hand instead. If you can't, you lose the game.
If a card would be put into your graveyard from anywhere, exile that card instead.

Summoner's Pact

Search your library for a green creature card, reveal it, put it into your hand, then shuffle.
At the beginning of your next upkeep, pay {2}{G}{G}. If you don't, you lose the game.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Sengir, the Dark Baron

Flying
Whenever another creature dies, put two +1/+1 counters on Sengir, the Dark Baron.
Whenever another player loses the game, you gain life equal to that player's life total as the turn began.
Partner (You can have two commanders if both have partner.)

Biovisionary

At the beginning of the end step, if you control four or more creatures named Biovisionary, you win the game.

Lich's Tomb

You don't lose the game for having 0 or less life.
Whenever you lose life, sacrifice a permanent for each 1 life you lost. (Damage causes loss of life.)

Exquisite Archangel

Flying
If you would lose the game, instead exile Exquisite Archangel and your life total becomes equal to your starting life total.

Revel in Riches

Whenever a creature an opponent controls dies, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")
At the beginning of your upkeep, if you control ten or more Treasures, you win the game.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Mechanized Production

Enchant artifact you control
At the beginning of your upkeep, create a token that's a copy of enchanted artifact. Then if you control eight or more artifacts with the same name as one another, you win the game.

Divine Intervention

Divine Intervention enters with two intervention counters on it.
At the beginning of your upkeep, remove an intervention counter from Divine Intervention.
When you remove the last intervention counter from Divine Intervention, the game is a draw.

Approach of the Second Sun

If this spell was cast from your hand and you've cast another spell named Approach of the Second Sun this game, you win the game. Otherwise, put Approach of the Second Sun into its owner's library seventh from the top and you gain 7 life.

Chance for Glory

Creatures you control gain indestructible. Take an extra turn after this one. At the beginning of that turn's end step, you lose the game.

Maze's End

This land enters tapped.
{T}: Add {C}.
{3}, {T}, Return this land to its owner's hand: Search your library for a Gate card, put it onto the battlefield, then shuffle. If you control ten or more Gates with different names, you win the game.

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Alchemist's Gambit

Cleave {4}{U}{U}{R} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Take an extra turn after this one. During that turn, damage can't be prevented. [At the beginning of that turn's end step, you lose the game.]
Exile Alchemist's Gambit.

Pact of Negation

Counter target spell.
At the beginning of your next upkeep, pay {3}{U}{U}. If you don't, you lose the game.

Jace, Wielder of Mysteries

If you would draw a card while your library has no cards in it, you win the game instead.
+1: Target player mills two cards. Draw a card.
−8: Draw seven cards. Then if your library has no cards in it, you win the game.

Simic Ascendancy

{1}{G}{U}: Put a +1/+1 counter on target creature you control.
Whenever one or more +1/+1 counters are put on a creature you control, put that many growth counters on Simic Ascendancy.
At the beginning of your upkeep, if Simic Ascendancy has twenty or more growth counters on it, you win the game.

Nine Lives

Hexproof
If a source would deal damage to you, prevent that damage and put an incarnation counter on Nine Lives.
When there are nine or more incarnation counters on Nine Lives, exile it.
When Nine Lives leaves the battlefield, you lose the game.

Last Chance

Vraska, Golgari Queen

+2: You may sacrifice another permanent. If you do, you gain 1 life and draw a card.
−3: Destroy target nonland permanent with mana value 3 or less.
−9: You get an emblem with "Whenever a creature you control deals combat damage to a player, that player loses the game."

Immortal Coil

{T}, Exile two cards from your graveyard: Draw a card.
If damage would be dealt to you, prevent that damage. Exile a card from your graveyard for each 1 damage prevented this way.
When there are no cards in your graveyard, you lose the game.

Happily Ever After

When Happily Ever After enters, each player gains 5 life and draws a card.
At the beginning of your upkeep, if there are five colors among permanents you control, there are six or more card types among permanents you control and/or cards in your graveyard, and your life total is greater than or equal to your starting life total, you win the game.

Mayael's Aria

At the beginning of your upkeep, put a +1/+1 counter on each creature you control if you control a creature with power 5 or greater. Then you gain 10 life if you control a creature with power 10 or greater. Then you win the game if you control a creature with power 20 or greater.

Vraska, Scheming Gorgon

+2: Creatures you control get +1/+0 until end of turn.
−3: Destroy target creature.
−10: Until end of turn, creatures you control gain deathtouch and "Whenever this creature deals damage to an opponent, that player loses the game."

Curse of Vengeance

Enchant player
Whenever enchanted player casts a spell, put a spite counter on Curse of Vengeance.
When enchanted player loses the game, you gain X life and draw X cards, where X is the number of spite counters on Curse of Vengeance.

Laboratory Maniac

If you would draw a card while your library has no cards in it, you win the game instead.

Transcendence

You don't lose the game for having 0 or less life.
When you have 20 or more life, you lose the game.
Whenever you lose life, you gain 2 life for each 1 life you lost. (Damage dealt to you causes you to lose life.)

Warrior's Oath

Helix Pinnacle

Shroud (This enchantment can't be the target of spells or abilities.)
{X}: Put X tower counters on Helix Pinnacle.
At the beginning of your upkeep, if there are 100 or more tower counters on Helix Pinnacle, you win the game.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Atemsis, All-Seeing

Flying
{2}{U}, {T}: Draw two cards, then discard a card.
Whenever Atemsis, All-Seeing deals damage to an opponent, you may reveal your hand. If cards with at least six different mana values are revealed this way, that player loses the game.

Mortal Combat

At the beginning of your upkeep, if twenty or more creature cards are in your graveyard, you win the game.

Azor's Elocutors

At the beginning of your upkeep, put a filibuster counter on Azor's Elocutors. Then if Azor's Elocutors has five or more filibuster counters on it, you win the game.
Whenever a source deals damage to you, remove a filibuster counter from Azor's Elocutors.

Darksteel Reactor

Indestructible (Effects that say "destroy" don't destroy this artifact.)
At the beginning of your upkeep, you may put a charge counter on Darksteel Reactor.
When Darksteel Reactor has twenty or more charge counters on it, you win the game.

Abyssal Persecutor

Flying, trample
You can't win the game and your opponents can't lose the game.

Lich

As Lich enters, you lose life equal to your life total.
You don't lose the game for having 0 or less life.
If you would gain life, draw that many cards instead.
Whenever you're dealt damage, sacrifice that many nontoken permanents. If you can't, you lose the game.
When Lich is put into a graveyard from the battlefield, you lose the game.

Lich's Mirror

If you would lose the game, instead shuffle your hand, your graveyard, and all permanents you own into your library, then draw seven cards and your life total becomes 20.

Chance Encounter

Whenever you win a coin flip, put a luck counter on Chance Encounter.
At the beginning of your upkeep, if Chance Encounter has ten or more luck counters on it, you win the game.

Thassa's Oracle

When Thassa's Oracle enters, look at the top X cards of your library, where X is your devotion to blue. Put up to one of them on top of your library and the rest on the bottom of your library in a random order. If X is greater than or equal to the number of cards in your library, you win the game. (Each {U} in the mana costs of permanents you control counts toward your devotion to blue.)

Nicol Bolas, Dragon-God

Nicol Bolas, Dragon-God has all loyalty abilities of all other planeswalkers on the battlefield.
+1: You draw a card. Each opponent exiles a card from their hand or a permanent they control.
−3: Destroy target creature or planeswalker.
−8: Each opponent who doesn't control a legendary creature or planeswalker loses the game.