Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Throne of the God-Pharaoh

At the beginning of your end step, each opponent loses life equal to the number of tapped creatures you control.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Dina, Soul Steeper

Whenever you gain life, each opponent loses 1 life.
{1}, Sacrifice another creature: Dina, Soul Steeper gets +X/+0 until end of turn, where X is the sacrificed creature's power.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Veinwitch Coven

Menace
Whenever you gain life, you may pay {B}. If you do, return target creature card from your graveyard to your hand.

Final Punishment

Target player loses life equal to the damage already dealt to that player this turn.

Wall of Limbs

Defender (This creature can't attack.)
Whenever you gain life, put a +1/+1 counter on Wall of Limbs.
{5}{B}{B}, Sacrifice Wall of Limbs: Target player loses X life, where X is Wall of Limbs's power.

Scion of the Swarm

Flying
Whenever you gain life, put a +1/+1 counter on Scion of the Swarm.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Scythe Specter

Flying
Whenever Scythe Specter deals combat damage to a player, each opponent discards a card. Each player who discarded a card with the highest mana value among cards discarded this way loses life equal to that mana value.

Death Watch

Enchant creature
When enchanted creature dies, its controller loses life equal to its power and you gain life equal to its toughness.

Blood Researcher

Menace (This creature can't be blocked except by two or more creatures.)
Whenever you gain life, put a +1/+1 counter on Blood Researcher.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Lisette, Dean of the Root

Whenever you gain life, you may pay {1}. If you do, put a +1/+1 counter on each creature you control and those creatures gain trample until end of turn.

Valentin, Dean of the Vein

Menace, lifelink
If a nontoken creature an opponent controls would die, exile it instead. When you do, you may pay {2}. If you do, create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."

Valentin, Dean of the Vein // Lisette, Dean of the Root

Pain's Reward

Each player may bid life. You start the bidding with a bid of any number. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and draws four cards.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Trudge Garden

Whenever you gain life, you may pay {2}. If you do, create a 4/4 green Fungus Beast creature token with trample.

Baneful Omen

At the beginning of your end step, you may reveal the top card of your library. If you do, each opponent loses life equal to that card's mana value.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)