Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Remorseless Punishment

Target opponent loses 5 life unless that player discards two cards or sacrifices a creature or planeswalker. Repeat this process once.

Eternity Vessel

Eternity Vessel enters with X charge counters on it, where X is your life total.
Landfall — Whenever a land you control enters, you may have your life total become the number of charge counters on Eternity Vessel.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Disciple of Bolas

When Disciple of Bolas enters, sacrifice another creature. You gain X life and draw X cards, where X is that creature's power.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Desolation

At the beginning of each end step, each player who tapped a land for mana this turn sacrifices a land. Desolation deals 2 damage to each player who sacrificed a Plains this way.

Locust Miser

Each opponent's maximum hand size is reduced by two.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Sudden Spoiling

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Until end of turn, creatures target player controls lose all abilities and have base power and toughness 0/2.

Tragic Slip

Target creature gets -1/-1 until end of turn.
Morbid — That creature gets -13/-13 until end of turn instead if a creature died this turn.

Magus of the Coffers

{2}, {T}: Add {B} for each Swamp you control.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Doomsday

Search your library and graveyard for five cards and exile the rest. Put the chosen cards on top of your library in any order. You lose half your life, rounded up.

Liliana Vess

+1: Target player discards a card.
−2: Search your library for a card, then shuffle and put that card on top.
−8: Put all creature cards from all graveyards onto the battlefield under your control.

Leyline of the Void

If Leyline of the Void is in your opening hand, you may begin the game with it on the battlefield.
If a card would be put into an opponent's graveyard from anywhere, exile it instead.

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis, Unshackled.

Hatred

As an additional cost to cast this spell, pay X life.
Target creature gets +X/+0 until end of turn.

Abyssal Persecutor

Flying, trample
You can't win the game and your opponents can't lose the game.

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Cathedral of War

Cathedral of War enters tapped.
Exalted (Whenever a creature you control attacks alone, that creature gets +1/+1 until end of turn.)
{T}: Add {C}.

Lich's Mirror

If you would lose the game, instead shuffle your hand, your graveyard, and all permanents you own into your library, then draw seven cards and your life total becomes 20.

Cabal Ritual

Add {B}{B}{B}.
Threshold — Add {B}{B}{B}{B}{B} instead if seven or more cards are in your graveyard.

Strip Mine

{T}: Add {C}.
{T}, Sacrifice Strip Mine: Destroy target land.

Grave Pact

Whenever a creature you control dies, each other player sacrifices a creature.

Behold the Beyond

Discard your hand. Search your library for three cards, put them into your hand, then shuffle.

Maralen of the Mornsong

Players can't draw cards.
At the beginning of each player's draw step, that player loses 3 life, searches their library for a card, puts it into their hand, then shuffles.

Malicious Affliction

Morbid — When you cast this spell, if a creature died this turn, you may copy Malicious Affliction and may choose a new target for the copy.
Destroy target nonblack creature.

Stabwhisker the Odious

At the beginning of each opponent's upkeep, that player loses 1 life for each card fewer than three in their hand.

Nezumi Shortfang

{1}{B}, {T}: Target opponent discards a card. Then if that player has no cards in hand, flip Nezumi Shortfang.

Nezumi Shortfang // Stabwhisker the Odious

Beseech the Queen

({2/B} can be paid with any two mana or with {B}. This card's mana value is 6.)
Search your library for a card with mana value less than or equal to the number of lands you control, reveal it, put it into your hand, then shuffle.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Swamp

Gnat Miser

Each opponent's maximum hand size is reduced by one.

Sign in Blood

Target player draws two cards and loses 2 life.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Dark Petition

Search your library for a card, put that card into your hand, then shuffle.
Spell mastery — If there are two or more instant and/or sorcery cards in your graveyard, add {B}{B}{B}.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Phage the Untouchable

When Phage the Untouchable enters, if you didn't cast it from your hand, you lose the game.
Whenever Phage deals combat damage to a creature, destroy that creature. It can't be regenerated.
Whenever Phage deals combat damage to a player, that player loses the game.

Sol Ring

Tribute to Hunger

Target opponent sacrifices a creature. You gain life equal to that creature's toughness.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control, then sacrifices a third of the lands they control. Round up each time.

Oppression

Whenever a player casts a spell, that player discards a card.

High Market

{T}: Add {C}.
{T}, Sacrifice a creature: You gain 1 life.

Eon Hub

Boseiju, Who Shelters All

Boseiju, Who Shelters All enters tapped.
{T}, Pay 2 life: Add {C}. If that mana is spent on an instant or sorcery spell, that spell can't be countered.

Temporal Extortion

When you cast this spell, any player may pay half their life, rounded up. If a player does, counter Temporal Extortion.
Take an extra turn after this one.

Forsaken Wastes

Players can't gain life.
At the beginning of each player's upkeep, that player loses 1 life.
Whenever Forsaken Wastes becomes the target of a spell, that spell's controller loses 5 life.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature.

Smokestack

At the beginning of your upkeep, you may put a soot counter on Smokestack.
At the beginning of each player's upkeep, that player sacrifices a permanent for each soot counter on Smokestack.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Dark Ritual

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

The Eldest Reborn

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Each opponent sacrifices a creature or planeswalker.
II — Each opponent discards a card.
III — Put target creature or planeswalker card from a graveyard onto the battlefield under your control.

Nighteyes the Desecrator

{4}{B}: Put target creature card from a graveyard onto the battlefield under your control.

Nezumi Graverobber

{1}{B}: Exile target card from an opponent's graveyard. If no cards are in that graveyard, flip Nezumi Graverobber.

Nezumi Graverobber // Nighteyes the Desecrator

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Dash Hopes

When you cast this spell, any player may pay 5 life. If a player does, counter Dash Hopes.
Counter target spell.

Infernal Darkness

Cumulative upkeep—Pay {B} and 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
If a land is tapped for mana, it produces {B} instead of any other type.

Kuon's Essence

At the beginning of each player's upkeep, that player sacrifices a creature.

Kuon, Ogre Ascendant

At the beginning of the end step, if three or more creatures died this turn, flip Kuon, Ogre Ascendant.