Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Deep-Cavern Bat

Flying, lifelink
When Deep-Cavern Bat enters, look at target opponent's hand. You may exile a nonland card from it until Deep-Cavern Bat leaves the battlefield.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Radiant Fountain

When Radiant Fountain enters, you gain 2 life.
{T}: Add {C}.

Helm of the Host

At the beginning of combat on your turn, create a token that's a copy of equipped creature, except the token isn't legendary. That token gains haste.
Equip {5}

Dread Osseosaur

Menace
Whenever Dread Osseosaur enters or attacks, you may mill two cards. (You may put the top two cards of your library into your graveyard.)

Visage of Dread

When Visage of Dread enters, target opponent reveals their hand. You choose an artifact or creature card from it. That player discards that card.
Craft with two creatures {5}{B} ({5}{B}, Exile this artifact, Exile the two from among creatures you control and/or creature cards in your graveyard: Return this card transformed under its owner's control. Craft only as a sorcery.)

Visage of Dread // Dread Osseosaur

Piper of the Swarm

Rats you control have menace.
{1}{B}, {T}: Create a 1/1 black Rat creature token.
{2}{B}{B}, {T}, Sacrifice three Rats: Gain control of target creature.

Leech Fanatic

During your turn, Leech Fanatic has lifelink.

Sorin the Mirthless

+1: Look at the top card of your library. You may reveal that card and put it into your hand. If you do, you lose life equal to its mana value.
−2: Create a 2/3 black Vampire creature token with flying and lifelink.
−7: Sorin the Mirthless deals 13 damage to any target. You gain 13 life.

Indulgent Aristocrat

Lifelink
{2}, Sacrifice a creature: Put a +1/+1 counter on each Vampire you control.

Obscura Storefront

When Obscura Storefront enters, sacrifice it. When you do, search your library for a basic Plains, Island, or Swamp card, put it onto the battlefield tapped, then shuffle and you gain 1 life.

Ichor Drinker

Lifelink
{B}, Exile Ichor Drinker from your graveyard: Incubate 2. Activate only as a sorcery. (Create an Incubator token with two +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)

Doom Blade

Go-Shintai of Hidden Cruelty

Deathtouch
At the beginning of your end step, you may pay {1}. When you do, destroy target creature with toughness X or less, where X is the number of Shrines you control.

Essence Infusion

Put two +1/+1 counters on target creature. It gains lifelink until end of turn.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Serrated Scorpion

When Serrated Scorpion dies, it deals 2 damage to each opponent and you gain 2 life.

Vraan, Executioner Thane

Whenever one or more other creatures you control die, each opponent loses 2 life and you gain 2 life. This ability triggers only once each turn.

Eternal Thirst

Enchant creature
Enchanted creature has lifelink and "Whenever a creature an opponent controls dies, put a +1/+1 counter on this creature." (Damage dealt by a creature with lifelink also causes its controller to gain that much life.)

Clackbridge Troll

Trample, haste
When Clackbridge Troll enters, target opponent creates three 0/1 white Goat creature tokens.
At the beginning of combat on your turn, any opponent may sacrifice a creature of their choice. If a player does, tap Clackbridge Troll, you gain 3 life, and you draw a card.

Echo of Dusk

Descend 4 — As long as there are four or more permanent cards in your graveyard, Echo of Dusk gets +1/+1 and has lifelink.

Swamp

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Reaper's Talisman

Whenever equipped creature attacks, it gains deathtouch until end of turn.
Whenever equipped creature attacks alone, defending player loses 2 life and you gain 2 life.
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Tarrian's Soulcleaver

Equipped creature has vigilance.
Whenever another artifact or creature is put into a graveyard from the battlefield, put a +1/+1 counter on equipped creature.
Equip {2}

Heartless Act

Choose one —
• Destroy target creature with no counters on it.
• Remove up to three counters from target creature.

Malakir Cullblade

Whenever a creature an opponent controls dies, put a +1/+1 counter on Malakir Cullblade.

Honden of Night's Reach

At the beginning of your upkeep, target opponent discards a card for each Shrine you control.

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Eliminate

Destroy target creature or planeswalker with mana value 3 or less.

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Rooftop Assassin

Flash
Flying, lifelink
When Rooftop Assassin enters, destroy target creature an opponent controls that was dealt damage this turn.

Malakir Blood-Priest

When Malakir Blood-Priest enters, each opponent loses X life and you gain X life, where X is the number of creatures in your party. (Your party consists of up to one each of Cleric, Rogue, Warrior, and Wizard.)

Sanitarium Skeleton

{2}{B}: Return Sanitarium Skeleton from your graveyard to your hand.

Boot Nipper

Boot Nipper enters with your choice of a deathtouch counter or a lifelink counter on it.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Power Word Kill

Destroy target non-Angel, non-Demon, non-Devil, non-Dragon creature.

Clawing Torment

Enchant artifact or creature
As long as enchanted permanent is a creature, it gets -1/-1 and can't block.
Enchanted permanent has "At the beginning of your upkeep, you lose 1 life."

Demon of Loathing

Flying, trample
Whenever Demon of Loathing deals combat damage to a player, that player sacrifices a creature of their choice.

Raise Dead

Return target creature card from your graveyard to your hand.

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Dead Man's Chest

Enchant creature an opponent controls
When enchanted creature dies, exile cards equal to its power from the top of its owner's library. You may cast spells from among those cards for as long as they remain exiled, and mana of any type can be spent to cast them.

Maestros Theater

When Maestros Theater enters, sacrifice it. When you do, search your library for a basic Island, Swamp, or Mountain card, put it onto the battlefield tapped, then shuffle and you gain 1 life.

Savage Gorger

Flying
At the beginning of your end step, if an opponent lost life this turn, put a +1/+1 counter on Savage Gorger. (Damage causes loss of life.)

Swift End

Destroy target creature or planeswalker. You lose 2 life. (Then exile this card. You may cast the creature later from exile.)

Murderous Rider

Lifelink
When Murderous Rider dies, put it on the bottom of its owner's library.

Murderous Rider // Swift End

Sanctum of Stone Fangs

At the beginning of your first main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Etched Familiar

When Etched Familiar dies, each opponent loses 2 life and you gain 2 life.

Strangling Grasp

Enchant creature or planeswalker an opponent controls
At the beginning of your upkeep, enchanted permanent's controller sacrifices a nonland permanent of their choice, then that player loses 1 life.

Vengeful Strangler

Vengeful Strangler can't block.
When Vengeful Strangler dies, return it to the battlefield transformed under your control attached to target creature or planeswalker an opponent controls.

Vengeful Strangler // Strangling Grasp

Leeching Lurker

Lifelink
Nightbound (If a player casts at least two spells during their own turn, it becomes day next turn.)

Curse of Leeches

Enchant player
As this permanent transforms into Curse of Leeches, attach it to a player.
At the beginning of enchanted player's upkeep, they lose 1 life and you gain 1 life.
Daybound (If a player casts no spells during their own turn, it becomes night next turn.)

Curse of Leeches // Leeching Lurker

Tamiyo's Journal

At the beginning of your upkeep, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")
{T}, Sacrifice three Clues: Search your library for a card, put that card into your hand, then shuffle.

Environmental Sciences

Search your library for a basic land card, reveal it, put it into your hand, then shuffle. You gain 2 life.

Hidden Necropolis

Hidden Necropolis enters tapped.
{T}: Add {B}.
{4}{B}, {T}, Sacrifice Hidden Necropolis: Discover 4. Activate only as a sorcery. (Exile cards from the top of your library until you exile a nonland card with mana value 4 or less. Cast it without paying its mana cost or put it into your hand. Put the rest on the bottom in a random order.)

Canonized in Blood

At the beginning of your end step, if you descended this turn, put a +1/+1 counter on target creature you control. (You descended if a permanent card was put into your graveyard from anywhere.)
{5}{B}{B}, Sacrifice Canonized in Blood: Create a 4/3 white and black Vampire Demon creature token with flying.

Nullpriest of Oblivion

Kicker {3}{B} (You may pay an additional {3}{B} as you cast this spell.)
Lifelink
Menace (This creature can't be blocked except by two or more creatures.)
When this creature enters, if it was kicked, return target creature card from your graveyard to the battlefield.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Professor Onyx

Magecraft — Whenever you cast or copy an instant or sorcery spell, each opponent loses 2 life and you gain 2 life.
+1: You lose 1 life. Look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
−3: Each opponent sacrifices a creature with the greatest power among creatures that player controls.
−8: Each opponent may discard a card. If they don't, they lose 3 life. Repeat this process six more times.

Unlikely Aid

Target creature gets +2/+0 and gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)