Laboratory Maniac

If you would draw a card while your library has no cards in it, you win the game instead.

Grim Guardian

Constellation — Whenever Grim Guardian or another enchantment you control enters, each opponent loses 1 life.

Trouble in Pairs

If an opponent would begin an extra turn, that player skips that turn instead.
Whenever an opponent attacks you with two or more creatures, draws their second card each turn, or casts their second spell each turn, you draw a card.

Balemurk Leech

Eerie — Whenever an enchantment you control enters and whenever you fully unlock a Room, each opponent loses 1 life.

Solitary Confinement

At the beginning of your upkeep, sacrifice Solitary Confinement unless you discard a card.
Skip your draw step.
You have shroud. (You can't be the target of spells or abilities.)
Prevent all damage that would be dealt to you.

Fear of Sleep Paralysis

Flying
Eerie — Whenever Fear of Sleep Paralysis or another enchantment you control enters and whenever you fully unlock a Room, tap up to one target creature and put a stun counter on it.
Stun counters can't be removed from permanents your opponents control. (They won't untap if they have stun counters.)

The Master of Keys

Flying
When The Master of Keys enters, put X +1/+1 counters on it and mill twice X cards.
Each enchantment card in your graveyard has escape. The escape cost is equal to the card's mana cost plus exile three other cards from your graveyard. (You may cast cards from your graveyard for their escape cost.)