Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Poet's Quill

When Poet's Quill enters, learn. (You may reveal a Lesson card you own from outside the game and put it into your hand, or discard a card to draw a card.)
Equipped creature gets +1/+1 and has lifelink.
Equip {1}{B}

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Dreadhorde Invasion

At the beginning of your upkeep, you lose 1 life and amass Zombies 1. (Put a +1/+1 counter on an Army you control. It's also a Zombie. If you don't control an Army, create a 0/0 black Zombie Army creature token first.)
Whenever a Zombie token you control with power 6 or greater attacks, it gains lifelink until end of turn.

Deluge of the Dead

When Deluge of the Dead enters, create two 2/2 black Zombie creature tokens.
{2}{B}: Exile target card from a graveyard. If it was a creature card, create a 2/2 black Zombie creature token.

Invasion of Innistrad

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
Flash
When Invasion of Innistrad enters, target creature an opponent controls gets -13/-13 until end of turn.

Invasion of Innistrad // Deluge of the Dead

Tragic Slip

Target creature gets -1/-1 until end of turn.
Morbid — That creature gets -13/-13 until end of turn instead if a creature died this turn.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Sidisi, Undead Vizier

Deathtouch
Exploit (When this creature enters, you may sacrifice a creature.)
When Sidisi, Undead Vizier exploits a creature, you may search your library for a card, put it into your hand, then shuffle.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Slice from the Shadows

This spell can't be countered. (This includes by the ward ability.)
Target creature gets -X/-X until end of turn.

Bellowing Mauler

At the beginning of your end step, each player loses 4 life unless they sacrifice a nontoken creature of their choice.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Greed

Swamp

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Geode Golem

Trample
Whenever Geode Golem deals combat damage to a player, you may cast your commander from the command zone without paying its mana cost. (You still pay any additional costs.)

Sol Ring

Arms of Hadar

Creatures target player controls get -2/-2 until end of turn.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Noxious Gearhulk

Menace
When Noxious Gearhulk enters, you may destroy another target creature. If a creature is destroyed this way, you gain life equal to its toughness.

Night's Whisper

Massacre Girl, Known Killer

Menace
Creatures you control have wither. (They deal damage to creatures in the form of -1/-1 counters.)
Whenever a creature an opponent controls dies, if its toughness was less than 1, draw a card.

Decanter of Endless Water

You have no maximum hand size.
{T}: Add one mana of any color.

Infernal Sovereign

Flying, trample
Skip your draw step.
Whenever you play a land or cast a spell, you draw a card and you lose 1 life.