The Lord of Pain

Menace
Your opponents can't gain life.
Whenever a player casts their first spell each turn, choose another target player. The Lord of Pain deals damage equal to that spell's mana value to the chosen player.

Solphim, Mayhem Dominus

If a source you control would deal noncombat damage to an opponent or a permanent an opponent controls, it deals double that damage to that player or permanent instead.
{1}{R/P}{R/P}, Discard two cards: Put an indestructible counter on Solphim, Mayhem Dominus. ({R/P} can be paid with either {R} or 2 life.)

Panicked Altisaur

Reach
{T}: Panicked Altisaur deals 2 damage to each opponent.

Harsh Mentor

Whenever an opponent activates an ability of an artifact, creature, or land on the battlefield, if it isn't a mana ability, Harsh Mentor deals 2 damage to that player.

Ob Nixilis, the Adversary

Casualty X. The copy isn't legendary and has starting loyalty X. (As you cast this spell, you may sacrifice a creature with power X. When you do, copy this spell. The copy becomes a token.)
+1: Each opponent loses 2 life unless they discard a card. If you control a Demon or Devil, you gain 2 life.
−2: Create a 1/1 red Devil creature token with "When this creature dies, it deals 1 damage to any target."
−7: Target player draws seven cards and loses 7 life.

Anathemancer

When Anathemancer enters, it deals damage to target player equal to the number of nonbasic lands that player controls.
Unearth {5}{B}{R} ({5}{B}{R}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Iridescent Vinelasher

Offspring {2} (You may pay an additional {2} as you cast this spell. If you do, when this creature enters, create a 1/1 token copy of it.)
Landfall — Whenever a land you control enters, this creature deals 1 damage to target opponent.

Fanatic of Mogis

When Fanatic of Mogis enters, it deals damage to each opponent equal to your devotion to red. (Each {R} in the mana costs of permanents you control counts toward your devotion to red.)

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Lightning Reaver

Haste; fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
Whenever Lightning Reaver deals combat damage to a player, put a charge counter on it.
At the beginning of your end step, Lightning Reaver deals damage equal to the number of charge counters on it to each opponent.

Torbran, Thane of Red Fell

If a red source you control would deal damage to an opponent or a permanent an opponent controls, it deals that much damage plus 2 instead.

Quest for Pure Flame

Whenever a source you control deals damage to an opponent, you may put a quest counter on Quest for Pure Flame.
Remove four quest counters from Quest for Pure Flame and sacrifice it: If any source you control would deal damage to a permanent or player this turn, it deals double that damage to that permanent or player instead.

Razorkin Needlehead

Razorkin Needlehead has first strike during your turn.
Whenever an opponent draws a card, Razorkin Needlehead deals 1 damage to them.

Witch Hunt

Players can't gain life.
At the beginning of your upkeep, Witch Hunt deals 4 damage to you.
At the beginning of your end step, target opponent chosen at random gains control of Witch Hunt.

Vial Smasher the Fierce

Whenever you cast your first spell each turn, choose an opponent at random. Vial Smasher the Fierce deals damage equal to that spell's mana value to that player or a planeswalker that player controls.
Partner (You can have two commanders if both have partner.)

Boltwave

Boltwave deals 3 damage to each opponent.

Hearthborn Battler

Haste
Whenever a player casts their second spell each turn, Hearthborn Battler deals 2 damage to target opponent.

Mogis, God of Slaughter

Indestructible
As long as your devotion to black and red is less than seven, Mogis isn't a creature.
At the beginning of each opponent's upkeep, Mogis deals 2 damage to that player unless they sacrifice a creature of their choice.

Worldfire

Exile all permanents. Exile all cards from all hands and graveyards. Each player's life total becomes 1.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Fiery Confluence

Choose three. You may choose the same mode more than once.
• Fiery Confluence deals 1 damage to each creature.
• Fiery Confluence deals 2 damage to each opponent.
• Destroy target artifact.

Flame Rift

Flame Rift deals 4 damage to each player.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Zoyowa Lava-Tongue

Deathtouch
At the beginning of your end step, if you descended this turn, each opponent may discard a card or sacrifice a permanent of their choice. Zoyowa Lava-Tongue deals 3 damage to each opponent who didn't. (You descended if a permanent card was put into your graveyard from anywhere.)

Price of Progress

Price of Progress deals damage to each player equal to twice the number of nonbasic lands that player controls.

Prisoner's Dilemma

Each opponent secretly chooses silence or snitch, then the choices are revealed. If each opponent chose silence, Prisoner's Dilemma deals 4 damage to each of them. If each opponent chose snitch, Prisoner's Dilemma deals 8 damage to each of them. Otherwise, Prisoner's Dilemma deals 12 damage to each opponent who chose silence.
Flashback {5}{R}{R}

Sunspine Lynx

Players can't gain life.
Damage can't be prevented.
When Sunspine Lynx enters, it deals damage to each player equal to the number of nonbasic lands that player controls.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Twinflame Tyrant

Flying
If a source you control would deal damage to an opponent or a permanent an opponent controls, it deals double that damage instead.

Swamp

Angrath's Marauders

If a source you control would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Chandra, Awakened Inferno

This spell can't be countered.
+2: Each opponent gets an emblem with "At the beginning of your upkeep, this emblem deals 1 damage to you."
−3: Chandra, Awakened Inferno deals 3 damage to each non-Elemental creature.
−X: Chandra, Awakened Inferno deals X damage to target creature or planeswalker. If a permanent dealt damage this way would die this turn, exile it instead.

Sulfuric Vortex

At the beginning of each player's upkeep, Sulfuric Vortex deals 2 damage to that player.
If a player would gain life, that player gains no life instead.

Cemetery Gatekeeper

First strike
When Cemetery Gatekeeper enters, exile a card from a graveyard.
Whenever a player plays a land or casts a spell, if it shares a card type with the exiled card, Cemetery Gatekeeper deals 2 damage to that player.

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Sawhorn Nemesis

As Sawhorn Nemesis enters, choose a player.
If a source would deal damage to the chosen player or a permanent they control, it deals double that damage instead.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Tunnel Ignus

Whenever a land enters under an opponent's control, if that player had another land enter the battlefield under their control this turn, Tunnel Ignus deals 3 damage to that player.

Kederekt Parasite

Whenever an opponent draws a card, if you control a red permanent, you may have Kederekt Parasite deal 1 damage to that player.

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Rampaging Ferocidon

Menace
Players can't gain life.
Whenever another creature enters, Rampaging Ferocidon deals 1 damage to that creature's controller.

Torture Pit

If a source you control would deal noncombat damage to an opponent, it deals that much damage plus 2 instead.
(You may cast either half. That door unlocks on the battlefield. As a sorcery, you may pay the mana cost of a locked door to unlock it.)

Spiked Corridor

When you unlock this door, create three 1/1 red Devil creature tokens with "When this creature dies, it deals 1 damage to any target."
(You may cast either half. That door unlocks on the battlefield. As a sorcery, you may pay the mana cost of a locked door to unlock it.)

Spiked Corridor // Torture Pit

Court of Embereth

When Court of Embereth enters, you become the monarch.
At the beginning of your upkeep, create a 3/1 red Knight creature token. Then if you're the monarch, Court of Embereth deals X damage to each opponent, where X is the number of creatures you control.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Roiling Vortex

At the beginning of each player's upkeep, Roiling Vortex deals 1 damage to them.
Whenever a player casts a spell, if no mana was spent to cast that spell, Roiling Vortex deals 5 damage to that player.
{R}: Your opponents can't gain life this turn.

City on Fire

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
If a source you control would deal damage to a permanent or player, it deals triple that damage instead.

Ankh of Mishra

Whenever a land enters, Ankh of Mishra deals 2 damage to that land's controller.

Serrated Scorpion

When Serrated Scorpion dies, it deals 2 damage to each opponent and you gain 2 life.

Kokusho, the Evening Star

Flying
When Kokusho, the Evening Star dies, each opponent loses 5 life. You gain life equal to the life lost this way.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Fiery Emancipation

If a source you control would deal damage to a permanent or player, it deals triple that damage to that permanent or player instead.

Zo-Zu the Punisher

Whenever a land enters, Zo-Zu the Punisher deals 2 damage to that land's controller.

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Tunneling Geopede

Landfall — Whenever a land you control enters, Tunneling Geopede deals 1 damage to each opponent.